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1.发明申请4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carvoxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases 失效4-溴-5-（2-氯 - 苯甲酰基氨基）-1H-吡唑-3-羧酸酰胺衍生物和相关化合物作为缓激肽b1受体拮抗剂，用于治疗炎性疾病公开(公告)号：US20060281733A1
公开(公告)日：2006-12-14
申请号：US10555519
申请日：2004-04-30
申请人： Jay Tung , Albert Garofalo , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , R. Jeffrey Neitz , Jennifer Marugg , Martin Neitzel
发明人： Jay Tung , Albert Garofalo , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , R. Jeffrey Neitz , Jennifer Marugg , Martin Neitzel
IPC分类号： A61K31/5377 , A61K31/5513 , A61K31/55 , A61K31/496 , A61K31/4545 , A61K31/454 , A61K31/4152 , C07D403/02
CPC分类号： C07D401/14 , C07D231/16 , C07D231/40 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/08
摘要： Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
摘要翻译： 公开了作为缓激肽B 1受体拮抗剂的式I和II化合物，并且可用于治疗由缓激肽B 1介导的哺乳动物中疾病或与疾病相关的不良症状， SUB>受体。 某些化合物表现出增加的效力，并且还预期表现出增加的作用持续时间。
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公开(公告)号：US20050165003A1
公开(公告)日：2005-07-28
申请号：US10976746
申请日：2004-10-29
申请人： Martin Neitzel , Michael Dappen , Jennifer Marugg
发明人： Martin Neitzel , Michael Dappen , Jennifer Marugg
IPC分类号： A61K31/4015 , A61K31/4025 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D207/14 , C07D211/56 , C07D223/10 , C07D223/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/12 , C07D471/04 , C07D498/04 , C07D43/02
CPC分类号： C04B35/632 , C07D223/10 , C07D223/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R1, R2, R3, R4, R3′, R10 and R11 are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
摘要翻译： 公开了用于治疗或预防认知障碍（例如阿尔茨海默病）的N-取代苯磺酰胺。 在式（I）中，R 1，R 2，R 3，R 4，R 3， 3'，R 10和R 11如本文所述。 本发明还包括含有式（I）化合物的药物组合物以及使用式（I）化合物治疗认知障碍的方法。
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公开(公告)号：US20120270902A1
公开(公告)日：2012-10-25
申请号：US13372126
申请日：2012-02-13
申请人： Martin Neitzel , Jennifer Marugg
发明人： Martin Neitzel , Jennifer Marugg
IPC分类号： A61K31/18 , C07D211/56 , A61K31/445 , C07D213/42 , A61K31/4406 , C07D207/14 , A61K31/40 , C07D277/28 , A61K31/426 , C07D417/12 , A61K31/4439 , C07D317/46 , A61K31/357 , C07D319/16 , C07D311/58 , A61K31/353 , A61K31/4409 , C07D233/52 , A61K31/4168 , C07D307/52 , A61K31/341 , C07D209/14 , A61K31/4045 , A61P25/28 , A61P7/04 , C07C311/17 , A61P25/00 , C07D231/06 , A61K31/415 , C07C311/20
CPC分类号： C07D277/24 , C07C311/16 , C07C311/17 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/51 , C07C317/32 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2602/42 , C07D209/14 , C07D211/58 , C07D231/06 , C07D307/52 , C07D307/81
摘要： The invention provides N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula (I), wherein R1, R2, R3, R4, and R3′, are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders, including Alzheimer's disease using compounds of Formula (I).
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4.发明授权4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases 失效4-溴-5-（2-氯 - 苯甲酰基氨基）-1H-吡唑-3-羧酸酰胺衍生物和相关化合物作为缓激肽B1受体拮抗剂，用于治疗炎性疾病公开(公告)号：US07417152B2
公开(公告)日：2008-08-26
申请号：US10555519
申请日：2004-04-30
申请人： Jay S. Tung , Albert W. Garofalo , Michael A. Pleiss , Jing Wu , David W. G. Wone , Ashley C. Guinn , Darren B. Dressen , R. Jeffrey Neitz , Jennifer Marugg , Martin Neitzel
发明人： Jay S. Tung , Albert W. Garofalo , Michael A. Pleiss , Jing Wu , David W. G. Wone , Ashley C. Guinn , Darren B. Dressen , R. Jeffrey Neitz , Jennifer Marugg , Martin Neitzel
IPC分类号： C07D231/12 , C07D233/04
CPC分类号： C07D401/14 , C07D231/16 , C07D231/40 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/08
摘要： Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
摘要翻译： 公开了作为缓激肽B 1受体拮抗剂的式I和II化合物，并且可用于治疗由缓激肽B 1介导的哺乳动物中疾病或与疾病相关的不良症状， SUB>受体。 某些化合物表现出增加的效力，并且还预期表现出增加的作用持续时间。
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5.发明申请4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carboxylic acid (phenyl) amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases 审中-公开4-溴-5-（2-氯 - 苯甲酰基氨基）-1 - 吡唑-3-羧酸（苯基）酰胺衍生物和相关化合物作为缓激肽b1受体拮抗剂，用于治疗炎性疾病公开(公告)号：US20070123531A1
公开(公告)日：2007-05-31
申请号：US10555508
申请日：2004-04-30
申请人： Albert Garofalo , Jay Tung , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , Jennifer Marugg , Martin Neitzel
发明人： Albert Garofalo , Jay Tung , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , Jennifer Marugg , Martin Neitzel
IPC分类号： A61K31/5377 , A61K31/4709 , A61K31/4439 , A61K31/416 , A61K31/4178 , A61K31/427 , A61K31/423 , C07D413/02 , C07D417/02 , C07D405/02 , C07D403/02
CPC分类号： C07D401/12 , C07D231/16 , C07D231/40 , C07D403/12 , C07D417/12
摘要： Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
摘要翻译： 公开了缓激肽B1受体拮抗剂的化合物，可用于治疗由缓激肽B1受体介导的哺乳动物中疾病或与疾病状况相关的不良症状。 某些化合物表现出增加的效力，并且还预期表现出增加的作用持续时间。
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公开(公告)号：US07208488B2
公开(公告)日：2007-04-24
申请号：US10976746
申请日：2004-10-29
IPC分类号： C07D223/12 , C07D211/54 , A61K31/55 , A61K31/445 , A61P25/28
CPC分类号： C04B35/632 , C07D223/10 , C07D223/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R1, R2, R3, R4, R3′, R10 and R11 are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
摘要翻译： 公开了用于治疗或预防认知障碍（例如阿尔茨海默病）的N-取代苯磺酰胺。 在式（I）中，R 1，R 2，R 3，R 4，R 3， 3'，R 10和R 11如本文所述。 本发明还包括含有式（I）化合物的药物组合物以及使用式（I）化合物治疗认知障碍的方法。
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公开(公告)号：US20060035884A1
公开(公告)日：2006-02-16
申请号：US11133738
申请日：2005-05-20
申请人： Martin Neitzel , Jennifer Marugg
发明人： Martin Neitzel , Jennifer Marugg
IPC分类号： C07D211/08 , A61K31/55
CPC分类号： C07D401/04 , C07D209/42 , C07D215/58 , C07D217/22 , C07D235/02 , C07D241/50 , C07D243/14 , C07D263/57 , C07D273/00 , C07D277/06 , C07D405/06 , C07D471/04 , C07D491/10
摘要： The invention provides N-cyclic sulfonamido compounds for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula I, wherein R4, R5, R6, R7, and R8, are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I as well as methods of treating cognitive disorders, including Alzheimer's disease using compounds of Formula I.
摘要翻译： 本发明提供用于治疗或预防认知障碍（例如阿尔茨海默病）的N-环磺酰氨基化合物。 特别感兴趣的化合物由式I定义，其中R 4，R 5，R 6，R 7， 和R 8，如说明书中所述。 本发明还包括包含式I化合物的药物组合物以及使用式I化合物治疗认知障碍（包括阿尔茨海默病）的方法。
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公开(公告)号：US08193389B2
公开(公告)日：2012-06-05
申请号：US11078990
申请日：2005-03-11
申请人： Martin Neitzel , Jennifer Marugg
发明人： Martin Neitzel , Jennifer Marugg
IPC分类号： C07C303/00 , A61K31/16
CPC分类号： C07D277/24 , C07C311/16 , C07C311/17 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/51 , C07C317/32 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2602/42 , C07D209/14 , C07D211/58 , C07D231/06 , C07D307/52 , C07D307/81
摘要： The invention provides N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula (I), wherein R1, R2, R3, R4, and R3′, are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders, including Alzheimer's disease using compounds of Formula (I).
摘要翻译： 本发明提供用于治疗或预防认知障碍（例如阿尔茨海默病）的N-取代苯磺酰胺。 特别感兴趣的化合物由式（I）定义，其中R 1，R 2，R 3，R 4和R 3'如说明书中所述。 本发明还包括含有式（I）化合物的药物组合物以及使用式（I）化合物治疗认知障碍（包括阿尔茨海默氏病）的方法。
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公开(公告)号：US20110212920A1
公开(公告)日：2011-09-01
申请号：US13103605
申请日：2011-05-09
IPC分类号： A61K31/55 , C07D401/12 , C07D417/12 , C07D223/12 , C07D413/12 , C07D413/14 , C07D403/12 , C07D401/14 , C07D471/08 , A61K31/69 , C07F5/04 , A61P25/28 , A61P25/00 , A61P25/16
CPC分类号： C04B35/632 , C07D223/10 , C07D223/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R1, R2, R3, R4, R3′, R10 and R11 are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
摘要翻译： 公开了用于治疗或预防认知障碍（例如阿尔茨海默病）的N-取代苯磺酰胺。 在式（I）中，R 1，R 2，R 3，R 4，R 3'，R 10和R 11如本文所述。 本发明还包括含有式（I）化合物的药物组合物以及使用式（I）化合物治疗认知障碍的方法。
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公开(公告)号：US07939657B2
公开(公告)日：2011-05-10
申请号：US11738863
申请日：2007-04-23
IPC分类号： C07D401/00 , C07D405/00
CPC分类号： C04B35/632 , C07D223/10 , C07D223/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R1, R2, R3, R4, R3′, R10 and R11 are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
摘要翻译： 公开了用于治疗或预防认知障碍（例如阿尔茨海默病）的N-取代苯磺酰胺。 在式（I）中，R 1，R 2，R 3，R 4，R 3'，R 10和R 11如本文所述。 本发明还包括含有式（I）化合物的药物组合物以及使用式（I）化合物治疗认知障碍的方法。
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