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    Inflatable balloon catheter structural designs and methods for treating diseased tissue of a patient
    52.
    发明申请
    Inflatable balloon catheter structural designs and methods for treating diseased tissue of a patient 失效
    充气球囊导管结构设计和治疗患者病变组织的方法

    公开(公告)号：US20040133254A1

    公开(公告)日：2004-07-08

    申请号：US10337159

    申请日：2003-01-07

    Inventor： Fred Sterzer ,  Daniel D. Mawhinney

    IPC: A61F002/00

    CPC classification number: A61B18/18 ,  A61B18/1815 ,  A61B2017/00084 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/00642 ,  A61B2018/1846 ,  A61B2018/1861

    Abstract: Each of various modifications of an integrated-structure inflatable balloon catheter design includes a longitudinal structure having a sharply-pointed insertion needle at a distal end of the longitudinal structure and an inflatable balloon situated intermediate a proximate end and the distal end of the longitudinal structure which is attached to said longitudinal structure. With the inflatable balloon in a deflated state, the insertion needle may be used to puncture the patient's skin and underlying sub-cutaneous tissue and place the deflated balloon in proximity to the diseased sub-cutaneous tissue, The balloon is then inflated to press against and thereby spatially deform the diseased sub-cutaneous tissue, after which the deformed diseased sub-cutaneous tissue may be therapeutically heated. This heating may be sufficient to cause the creation of a permanent cavity in the deformed diseased sub-cutaneous tissue which persists after the catheter is withdrawn. This permits any selected one of various therapeutic substances to be introduced into this a permanent cavity. One modification employs a balloon having a selected non-uniform, odd pattern shape which, when inflated, cooperates with the shape of the diseased sub-cutaneous tissue. This one modification also may be beneficially used in prostate-treating balloon catheters, which do not have a sharply-pointed insertion needle at the distal end thereof.

    Abstract translation: 集成结构可充气球囊导管设计的各种修改包括纵向结构，其在纵向结构的远端具有尖锐的插入针，以及位于纵向结构的近端和远端之间的可充气气囊， 附接到所述纵向结构。 在充气气囊处于放气状态时，插入针可以用于刺穿患者的皮肤和下面的皮下组织，并将放气的球囊放置在患病的皮下组织附近。然后使气囊膨胀以压住和 从而在空间上变形患病的皮下组织，之后变形的患病皮下组织可以被治疗加热。 这种加热可能足以导致在导管被拔出之后持续的变形的患病的皮下组织中产生永久性空腔。 这允许将各种治疗物质中的任何选定的一种引入到该永久腔中。 一种修改使用具有选定的不均匀的奇数图案形状的气球，当膨胀时，该气球与患病的皮下组织的形状配合。 这种修改也可以有益地用于前列腺治疗气囊导管，其在其末端没有尖锐的插入针。

    Microwave ablation device
    53.
    发明申请
    Microwave ablation device 审中-公开
    微波消融装置

    公开(公告)号：US20030065317A1

    公开(公告)日：2003-04-03

    申请号：US10247080

    申请日：2002-09-19

    Inventor： Eric N. Rudie ,  Stanley E. Kluge

    IPC: A61B018/04

    CPC classification number: A61N5/045 ,  A61B18/18 ,  A61B18/1815 ,  A61B2018/00023 ,  A61B2018/1846 ,  A61B2018/1861 ,  A61N2005/005

    Abstract: A tissue ablation device includes a catheter shaft having an antenna lumen, an impedance-matched microwave antenna carried in the antenna lumen of the catheter shaft, at least one cooling lumen in the catheter shaft around the antenna lumen for circulation of cooling fluid, and a microwave generator operatively coupled to the antenna for energizing the antenna to create a lesion in the targeted tissue around the catheter shaft having a controlled location and size. In an exemplary embodiment, a tip is attached to an end of the catheter shaft for penetrating the tissue targeted for treatment. The device is effective for laparascopic or percutaneous procedures to treat tissues such as the kidney.

    Abstract translation: 组织消融装置包括具有天线腔的导管轴，在导管轴的天线腔内承载的阻抗匹配的微波天线，围绕天线腔的导管轴中的至少一个冷却腔，用于冷却流体的循环，以及 微波发生器可操作地耦合到天线，用于激励天线，以在具有受控位置和尺寸的导管轴周围的靶组织中产生损伤。 在示例性实施例中，尖端附接到导管轴的端部，用于穿透靶向治疗的组织。 该装置对于治疗诸如肾脏的组织的腹腔镜或经皮手术是有效的。

    Track ablation device and methods of use
    54.
    发明授权
    Track ablation device and methods of use 有权
    跟踪消融装置及使用方法

    公开(公告)号：US06355033B1

    公开(公告)日：2002-03-12

    申请号：US09356077

    申请日：1999-07-16

    Applicant: Jack W. Moorman ,  M. Elizabeth Bush

    Inventor： Jack W. Moorman ,  M. Elizabeth Bush

    IPC: A61B1804

    CPC classification number: A61B10/0233 ,  A61B10/0275 ,  A61B17/3403 ,  A61B18/1477 ,  A61B18/18 ,  A61B18/1815 ,  A61B90/11 ,  A61B2018/00577 ,  A61B2018/183 ,  A61B2018/1846 ,  A61B2090/3937

    Abstract: A modular biopsy, ablation and track coagulation needle apparatus is disclosed that allows the biopsy needle to be inserted into the delivery needle and removed when not needed, and that allows an inner ablation needle to be introduced and coaxially engaged with the delivery needle to more effectively biopsy a tumor, ablate it and coagulate the track through ablation while reducing blood loss and track seeding. The ablation needle and biopsy needle are adapted to in situ assembly with the delivery needle. In a preferred embodiment, the ablation needle, when engaged with the delivery needle forms a coaxial connector adapted to electrically couple to an ablating source. Methods for biopsying and ablating tumors using the device and coagulating the track upon device removal are also provided.

    Abstract translation: 公开了一种模块化活检，消融和跟踪凝固针装置，其允许活检针插入输送针并且在不需要时被移除，并且允许内消融针被引导并与输送针同轴地接合以更有效地 活检肿瘤，消融并通过消融凝固轨道，同时减少失血和追踪播种。 消融针和活检针适于与输送针原位组装。 在优选实施例中，消融针当与输送针接合时形成适于电耦合到消融源的同轴连接器。 还提供了使用装置活组织切割和消融肿瘤并在装置移除时凝固轨道的方法。

    Device and method for preventing restenosis
    55.
    发明授权
    Device and method for preventing restenosis 失效
    用于预防再狭窄的装置和方法

    公开(公告)号：US06223085B1

    公开(公告)日：2001-04-24

    申请号：US08852154

    申请日：1997-05-06

    Applicant: Mitchell Dann ,  Scott P. Thome ,  Jonathan R. McGrath ,  Eric N. Rudie ,  Jonathan L. Flachman ,  Teruo T. Hirose

    Inventor： Mitchell Dann ,  Scott P. Thome ,  Jonathan R. McGrath ,  Eric N. Rudie ,  Jonathan L. Flachman ,  Teruo T. Hirose

    IPC: A61B1736

    CPC classification number: A61B18/18 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/22002 ,  A61B2017/22038 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00214 ,  A61B2018/00369 ,  A61B2018/00422 ,  A61B2018/1435 ,  A61B2018/183 ,  A61B2018/1838 ,  A61B2018/1846 ,  A61B2018/1861 ,  A61N5/045

    Abstract: A method and apparatus for reducing restenosis of a stenotic region of a blood vessel after performing a dilatation angioplasty treatment is disclosed. The method includes radiating microwave energy from a microwave antenna to kill a medial tissue layer of the blood vessel in the stenotic region. The radiation is applied during or after inflation of dilatation balloon to permanently dilate the stenotic region. When radiation is applied during dilatation of the stenotic region, the dilatation balloon forms a seal against the inner wall surface of the blood vessel to exclude blood in the vessel from contacting the stenotic region. The method preferably further includes cooling the blood circulating in the blood vessel about a shaft of the catheter with cooling fluid circulating within cooling lumens of the catheter and cooling an inner wall surface of the blood vessel in the stenotic region during the application of radiation to the medial cell layer. Finally, the method also preferably includes perfusing blood in the vessel through the catheter across the stenotic region during dilatation of the stenotic region to maintain circulation of blood through the blood vessel during the dilatation of the stenotic region.

    Abstract translation: 公开了一种用于在进行扩张血管成形术治疗后减少血管狭窄区域的再狭窄的方法和装置。 该方法包括从微波天线辐射微波能量以杀死狭窄区域中血管的内侧组织层。 在膨胀气球充气期间或之后施加辐射以永久扩张狭窄区域。 当在狭窄区域的扩张期间施加辐射时，扩张气囊对血管的内壁表面形成密封，以排除血管中的血液与狭窄区域接触。 该方法优选还包括：在导管冷却腔内循环的冷却流体冷却在血管周围的血液循环的血液，并且在将辐射施加到第二导管的过程中冷却狭窄区域中血管的内壁表面 内侧细胞层。 最后，该方法还优选包括在狭窄区域的扩张期间通过穿过狭窄区域的导管在血管中灌注血液，以在狭窄区域的扩张期间维持血液通过血管的循环。

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