公开(公告)号：US06223085B1

公开(公告)日：2001-04-24

申请号：US08852154

申请日：1997-05-06

Applicant: Mitchell Dann ,  Scott P. Thome ,  Jonathan R. McGrath ,  Eric N. Rudie ,  Jonathan L. Flachman ,  Teruo T. Hirose

Inventor： Mitchell Dann ,  Scott P. Thome ,  Jonathan R. McGrath ,  Eric N. Rudie ,  Jonathan L. Flachman ,  Teruo T. Hirose

IPC: A61B1736

CPC classification number: A61B18/18 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/22002 ,  A61B2017/22038 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00214 ,  A61B2018/00369 ,  A61B2018/00422 ,  A61B2018/1435 ,  A61B2018/183 ,  A61B2018/1838 ,  A61B2018/1846 ,  A61B2018/1861 ,  A61N5/045

Abstract: A method and apparatus for reducing restenosis of a stenotic region of a blood vessel after performing a dilatation angioplasty treatment is disclosed. The method includes radiating microwave energy from a microwave antenna to kill a medial tissue layer of the blood vessel in the stenotic region. The radiation is applied during or after inflation of dilatation balloon to permanently dilate the stenotic region. When radiation is applied during dilatation of the stenotic region, the dilatation balloon forms a seal against the inner wall surface of the blood vessel to exclude blood in the vessel from contacting the stenotic region. The method preferably further includes cooling the blood circulating in the blood vessel about a shaft of the catheter with cooling fluid circulating within cooling lumens of the catheter and cooling an inner wall surface of the blood vessel in the stenotic region during the application of radiation to the medial cell layer. Finally, the method also preferably includes perfusing blood in the vessel through the catheter across the stenotic region during dilatation of the stenotic region to maintain circulation of blood through the blood vessel during the dilatation of the stenotic region.

Abstract translation: 公开了一种用于在进行扩张血管成形术治疗后减少血管狭窄区域的再狭窄的方法和装置。 该方法包括从微波天线辐射微波能量以杀死狭窄区域中血管的内侧组织层。 在膨胀气球充气期间或之后施加辐射以永久扩张狭窄区域。 当在狭窄区域的扩张期间施加辐射时，扩张气囊对血管的内壁表面形成密封，以排除血管中的血液与狭窄区域接触。 该方法优选还包括：在导管冷却腔内循环的冷却流体冷却在血管周围的血液循环的血液，并且在将辐射施加到第二导管的过程中冷却狭窄区域中血管的内壁表面 内侧细胞层。 最后，该方法还优选包括在狭窄区域的扩张期间通过穿过狭窄区域的导管在血管中灌注血液，以在狭窄区域的扩张期间维持血液通过血管的循环。

公开(公告)号：US5861021A

公开(公告)日：1999-01-19

申请号：US771214

申请日：1996-12-20

Applicant: Scott P. Thome ,  Eric N. Rudie ,  Mitchell Dann ,  Teruo T. Hirose

Inventor： Scott P. Thome ,  Eric N. Rudie ,  Mitchell Dann ,  Teruo T. Hirose

IPC: A61B18/18 ,  A61N5/02

CPC classification number: A61B18/1815 ,  A61B18/18

Abstract: A method of applying microwave energy to cardiac tissue uses a catheter adapted for insertion into a cardiac chamber and which includes a microwave antenna, a cooling lumen structure, and an inflatable cooling balloon. Necrosing levels of microwave energy are delivered from the microwave antenna to diseased cardiac tissue spaced from the catheter. Tissues immediately surrounding the catheter are cooled and microwave energy emitted by the antenna is selectively absorbed by the cooling lumen structure surrounding the antenna. The cooling balloon of the catheter is positioned adjacent the antenna and partially surrounds the cooling lumen structure on one side of the catheter to provide additional cooling capability and additional microwave energy absorption on the side of the catheter opposite the diseased cardiac tissue to prevent unwanted heating of blood within the cardiac chamber.

Abstract translation: 将微波能量施加到心脏组织的方法使用适于插入心室的导管，其包括微波天线，冷却腔结构和可充气冷却气球。 微波能量的破坏水平从微波天线传送到与导管间隔开的患病心脏组织。 导管周围的组织被冷却，由天线发射的微波能量被围绕天线的冷却管腔结构选择性地吸收。 导管的冷却球囊位于天线附近并且部分地围绕导管一侧的冷却腔结构，以在与病态心脏组织相对的导管侧面提供额外的冷却能力和额外的微波能量吸收，以防止不期望的加热 心脏腔内的血液。