公开(公告)号：US20060122820A1

公开(公告)日：2006-06-08

申请号：US11002432

申请日：2004-12-03

Applicant: Frederick Wieland ,  Frederick Kuhl ,  Michael White

Inventor： Frederick Wieland ,  Frederick Kuhl ,  Michael White

IPC: G06F9/45

CPC classification number: G06F17/5009 ,  G06F17/5095

Abstract: A scripting language enables a systems analyst to write one or more scripts to manage the behavior of a simulation model, without having detailed knowledge of the programming language or the software architecture of the simulation model. Script specifications define the simulation procedures that the underlying simulation model expects to be present. Script definitions are prepared to change different purposes or behaviors of the simulation model. The script definitions and script specifications are matched and translated to generate a simulation code sequence. The simulation code sequence is combined with the simulation code representing the underlying simulation model. During the combination, the structure or behavior of the simulation model is manipulated or changed by commands or procedures introduced by the script-based simulation code sequence.

Abstract translation: 脚本语言使系统分析人员能够编写一个或多个脚本来管理仿真模型的行为，而无需详细了解仿真模型的编程语言或软件架构。 脚本规范定义了底层仿真模型预期存在的仿真过程。 脚本定义准备改变模拟模型的不同目的或行为。 脚本定义和脚本规范进行匹配和转换，以生成一个模拟代码序列。 仿真代码序列与代表底层仿真模型的仿真代码相结合。 在组合期间，通过基于脚本的仿真代码序列引入的命令或过程来操纵或改变仿真模型的结构或行为。

公开(公告)号：US20060042949A1

公开(公告)日：2006-03-02

申请号：US10928770

申请日：2004-08-27

Applicant: Gregory McCollum ,  Geoffrey Webster ,  Michael White

Inventor： Gregory McCollum ,  Geoffrey Webster ,  Michael White

IPC: C25B7/00 ,  B01D57/02

CPC classification number: C09D5/4419 ,  C09D5/4492

Abstract: The invention provides a curable electrodepositable coating composition that has improved durability in the presence of metal ions. The coating composition includes one or more ungelled, active hydrogen-containing ionic salt group-containing resins which are electrodepositable on an electrode, one or more curing agents, and one or more metal deactivators.

公开(公告)号：US20060024293A1

公开(公告)日：2006-02-02

申请号：US11233252

申请日：2005-09-21

Applicant: Jochen Salfeld ,  Deborah Allen ,  Hendricus Hoogenboom ,  Zehra Kaymakcalan ,  Boris Labkovsky ,  John Mankovich ,  Brian McGuinness ,  Andrew Roberts ,  Paul Sakorafas ,  David Schoenhaut ,  Tristan Vaughan ,  Michael White ,  Alison Wilton

Inventor： Jochen Salfeld ,  Deborah Allen ,  Hendricus Hoogenboom ,  Zehra Kaymakcalan ,  Boris Labkovsky ,  John Mankovich ,  Brian McGuinness ,  Andrew Roberts ,  Paul Sakorafas ,  David Schoenhaut ,  Tristan Vaughan ,  Michael White ,  Alison Wilton

IPC: A61K39/395

CPC classification number: C07K16/241 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  Y02A50/412 ,  Y10S424/80 ,  Y10S424/81 ,  Y10S530/868

Abstract: Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize hTNFα activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hTNFα and for inhibiting hTNFα activity, e.g., in a human subject suffering from a disorder in which hTNFα activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

Abstract translation: 公开了特异性结合人肿瘤坏死因子α（hTNFα）的人抗体，优选重组人抗体。 这些抗体对hTNFα具有高亲和力（例如，K N = 10 -8 M或更低），hTNFalpha解离的缓慢速率（例如，K off 或更低），并在体外和体内中和hTNFα活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 本发明的抗体或抗体部分可用于检测hTNFα和抑制hTNFα活性，例如在患有hTNFα活性有害的病症的人类受试者中。 用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。

公开(公告)号：US20050181139A1

公开(公告)日：2005-08-18

申请号：US11036453

申请日：2005-01-14

Applicant: Dennis Jones ,  Gregory McCollum ,  Mark McMillen ,  Anthony Notte ,  Michael Pawlik ,  Steven Perrine ,  Michael White

Inventor： Dennis Jones ,  Gregory McCollum ,  Mark McMillen ,  Anthony Notte ,  Michael Pawlik ,  Steven Perrine ,  Michael White

IPC: B05D3/02 ,  B05D7/00 ,  B05D7/14 ,  B05D7/16

CPC classification number: C09D5/08 ,  B05D3/0254 ,  B05D7/14 ,  B05D7/16 ,  B05D7/51 ,  B05D7/52 ,  B05D7/546 ,  B05D7/56 ,  B05D2202/10 ,  B05D2701/00 ,  B05D2701/40 ,  C23C22/34 ,  C23C22/83

Abstract: The present invention is drawn to a process for applying a multi-layer coating to at least a portion of a ferrous substrate. The process comprises the steps of: (a) providing a ferrous substrate; (b) applying to at least a portion of the ferrous substrate a film-forming composition that contains at least one of a corrosion inhibiting pigment and an electroconductive pigment; (c) curing the film-forming composition that was applied to the ferrous substrate in step (b); (d) forming the ferrous substrate into an end-use shape; (e) contacting at least a portion of the formed ferrous substrate with a treatment composition to yield a treated substrate; and (f) applying at least one coating composition to at least a portion of the treated substrate to form a coated substrate. The treatment composition comprises an aqueous solution of a polymer derived from vinylidene chloride.

Abstract translation: 本发明涉及将多层涂层施加到铁基底的至少一部分的方法。 该方法包括以下步骤：（a）提供铁基底; （b）向含铁基材的至少一部分施加含有腐蚀抑制颜料和导电颜料中的至少一种的成膜组合物; （c）固化在步骤（b）中施加到铁基底上的成膜组合物; （d）将铁基底形成终端使用形状; （e）使形成的铁基底的至少一部分与处理组合物接触以产生经处理的基底; 和（f）将至少一种涂料组合物施加到经处理的基材的至少一部分以形成涂布的基材。 处理组合物包含衍生自偏二氯乙烯的聚合物的水溶液。

公开(公告)号：US20050168595A1

公开(公告)日：2005-08-04

申请号：US10929962

申请日：2004-08-30

Applicant: Michael White

Inventor： Michael White

IPC: G06T5/00 ,  H04N1/56 ,  H04N5/228

CPC classification number: G06T5/004 ,  H04N1/56

Abstract: The present invention provides numerous automated processes with which to enhance the quality of digital images. The process may be easily and intuitively chosen based on the type or genre of digital image. The overall process involves first acquiring the digital image. This image may be a digital image to be edited within a photo processing software suite or acquired by a device such as a camera or scanner. Once acquired the genre associated with the image is identified. This identification may be based on information contained within the image being imported into a photo processing software suite, may be identified by analyzing the composition and makeup of the digital image, or the actual hardware setting associated with acquiring the image with a scanner, camera or other like device. Processes corresponding to the genre are selected and applied to the image to produce a professional quality enhanced digital image.

Abstract translation: 本发明提供了许多用于提高数字图像质量的自动化过程。 可以基于数字图像的类型或类型容易且直观地选择该过程。 整个过程包括首先获取数字图像。 该图像可以是要在照片处理软件套件内编辑或由诸如相机或扫描仪的设备获取的数字图像。 一旦获得，与图像相关联的类型被识别。 该识别可以基于被导入到照片处理软件套件中的图像中包含的信息，可以通过分析数字图像的组成和组成或与通过扫描仪，照相机获取图像相关联的实际硬件设置来识别 其他类似设备。 选择对应于类型的处理并将其应用于图像以产生专业质量增强的数字图像。

公开(公告)号：US06914128B1

公开(公告)日：2005-07-05

申请号：US09534717

申请日：2000-03-24

Applicant: Jochen Salfeld ,  Michael Roguska ,  Michael Paskind ,  Subhashis Banerjee ,  Daniel Tracey ,  Michael White ,  Zehra Kaymakcalan ,  Boris Labkovsky ,  Paul Sakorafas ,  Geertruida M. Veldman ,  Amy Venturini ,  Angela Widom ,  Stuart Friedrich ,  Nicholas W. Warne ,  Angela Myles ,  John Gawain Elvin ,  Alexander Robert Duncan ,  Elaine Joy Derbyshire ,  Sara Carmen ,  Thor Las Holtet ,  Sarah Leila Du Fou ,  Stephen Smith

Inventor： Jochen Salfeld ,  Michael Roguska ,  Michael Paskind ,  Subhashis Banerjee ,  Daniel Tracey ,  Michael White ,  Zehra Kaymakcalan ,  Boris Labkovsky ,  Paul Sakorafas ,  Geertruida M. Veldman ,  Amy Venturini ,  Angela Widom ,  Stuart Friedrich ,  Nicholas W. Warne ,  Angela Myles ,  John Gawain Elvin ,  Alexander Robert Duncan ,  Elaine Joy Derbyshire ,  Sara Carmen ,  Thor Las Holtet ,  Sarah Leila Du Fou ,  Stephen Smith

IPC: C07K16/24 ,  C07K16/18 ,  C12P21/08

CPC classification number: C07K16/244 ,  A61K9/0019 ,  A61K38/208 ,  A61K39/00 ,  A61K39/3955 ,  A61K39/39591 ,  A61K45/06 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K2039/505 ,  C07K14/5434 ,  C07K16/00 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/94 ,  Y10S514/863 ,  Y10S514/885 ,  Y10S514/886

Abstract: Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

Abstract translation: 公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。 优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。 用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。

公开(公告)号：US20050132413A1

公开(公告)日：2005-06-16

申请号：US11049776

申请日：2005-02-03

Applicant: Ernesto Barreyro ,  Timothy Frahm ,  Michael White

Inventor： Ernesto Barreyro ,  Timothy Frahm ,  Michael White

IPC: H04N5/38 ,  H04N5/44 ,  H04N7/173 ,  H04N5/50 ,  H04N7/16

CPC classification number: H04N5/38 ,  H04N5/4401 ,  H04N21/4345

Abstract: A tuner of a digital television signal translator tunes to receive an RF digital television signal on a first selected television channel. A demodulator provides a baseband digital television signal from the RF digital television signal to which the tuner is tuned. The baseband television signal includes a data component identifying the first selected channel. A data replacer replaces the data component identifying the first selected channel with a data component identifying a second selected channel different from the first selected channel. The output of a modulator is modulated by the baseband television signal including the data component identifying the second selected channel for transmission as a digital television signal on the second selected channel.

Abstract translation: 数字电视信号转换器的调谐器调谐以在第一选择的电视频道上接收RF数字电视信号。 解调器从调谐器调谐到的RF数字电视信号提供基带数字电视信号。 基带电视信号包括识别第一选定信道的数据分量。 数据替换器用识别与第一选定信道不同的第二选定信道的数据组件替代识别第一所选信道的数据组件。 调制器的输出由基带电视信号调制，该基带电视信号包括标识用于传输的第二选定信道的数据分量作为第二选定信道上的数字电视信号。

公开(公告)号：US20050041793A1

公开(公告)日：2005-02-24

申请号：US10890922

申请日：2004-07-14

Applicant: Paul Fulton ,  Andre Nakaso ,  John Drewry ,  Michael White ,  Steven Schramm ,  Saurav Chatterjee

Inventor： Paul Fulton ,  Andre Nakaso ,  John Drewry ,  Michael White ,  Steven Schramm ,  Saurav Chatterjee

IPC: H04L20060101 ,  H04M3/42 ,  H04M3/436

CPC classification number: H04M3/436 ,  H04M3/42093 ,  H04M3/42263 ,  H04M3/42365 ,  H04M2203/1091 ,  H04M2203/2011 ,  H04M2207/206

Abstract: A communication system is provided that uses loosely-coupled client-server architectures to improve the efficiency of communications. The communication system includes client and facilitator applications. The client application is a component of processor-based mobile communication devices. The facilitator application is hosted on one or more servers or other processor-based devices, and communicates with the client application via one or more couplings. The facilitator application can also be distributed among one or more portable processor-based devices including the communication devices hosting the client application. The communication system improves efficiency of voice communications by allowing communication device users to dynamically manage how and when mobile calls take place, intelligently screen calls based on caller identity, urgency, and subject matter, determine which contacts in a directory are available to talk and which ones choose not to be disturbed, and increase accessibility of enterprise and personal contact information from mobile phones.

Abstract translation: 提供了一种使用松散耦合的客户端 - 服务器架构来提高通信效率的通信系统。 通信系统包括客户端和辅助应用程序。 客户端应用程序是基于处理器的移动通信设备的组件。 辅导员应用程序托管在一个或多个服务器或其他基于处理器的设备上，并通过一个或多个耦合与客户端应用程序进行通信。 辅助应用程序还可以分布在一个或多个基于便携式处理器的设备中，包括托管客户端应用的通信设备。 通信系统通过允许通信设备用户动态地管理如何以及何时发生移动呼叫，提高语音通信的效率，基于呼叫者身份，紧急性和主题智能地屏蔽呼叫，确定目录中的哪些联系人可用于谈话以及哪个 选择不受打扰，增加手机企业和个人联系信息的可访问性。

公开(公告)号：US20050006456A1

公开(公告)日：2005-01-13

申请号：US10798573

申请日：2004-03-12

Applicant: Michael White

Inventor： Michael White

IPC: G06Q10/00 ,  G06F7/00 ,  G07B15/02

CPC classification number: G06Q10/08

Abstract: A logistics chain management system for which provides a network and databases to enable exporters or importers to book transport and storage facilities for all stages of the export/import transport/storage chain. An electronic document is created which eliminates the need to re enter data and thus reduces the incidence of errors. Quality assurance is achieved by monitoring consignments of goods with data loggers. All participants sign an agreement including predetermined transport conditions for the goods and a system manager monitors compliance using the data loggers. The system allows the consignee to acknowledge that the conditions have been complied with at the time of receipt of the goods.

Abstract translation: 一个物流链管理系统提供一个网络和数据库，使出口商或进口商能够为出口/进口运输/存储链的所有阶段预订运输和仓储设施。 创建一个电子文档，无需重新输入数据，从而减少错误的发生。 通过监控具有数据记录器的货物的货物来实现质量保证。 所有参与者签署协议，包括货物的预定运输条件，系统管理员使用数据记录器监控合规性。 该系统允许收货人在收到货物时确认条件已被遵守。

公开(公告)号：US20210378166A1

公开(公告)日：2021-12-09

申请号：US17187854

申请日：2021-03-22

Applicant: Ryan Curran ,  Michael White ,  Richard Gregory Elmer

Inventor： Ryan Curran ,  Michael White ,  Richard Gregory Elmer

IPC: A01D7/04

Abstract: A device for leveling a surface; the device includes a shaft, a handle-means and a head-assembly. The shaft is selectively retractable, and the head-assembly is foldable to enable compact storage. The device is for personal use by a user in leveling a surface; for example, a sand bunker/sand trap on a golf course. In some versions, the device further includes an attachment-means for attaching the device to a bag.