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公开(公告)号：US20050184516A1
公开(公告)日：2005-08-25
申请号：US10784385
申请日：2004-02-23
Applicant: Daniel Seguin , Gregory Mathus
Inventor： Daniel Seguin , Gregory Mathus
CPC classification number: B01L3/0279 , B01L3/021 , B01L3/0213 , B01L3/0275
Abstract: A mounting fixture for connecting pipettes of various sizes to the air channel of a pipettor comprises a tubular nose having a proximate end secured to the pipettor and an open distal end. A resilient retainer lines the interior of the tubular nose. The retainer has an axial passageway communicating at its entry and exit openings respectively with the open distal end of the tubular nose and with the air channel of the pipettor. The passageway is tapered from a maximum diameter at its entry opening to a minimum diameter at its exit opening. The entry opening is sized to axially receive the largest of the pipettes and the sleeve is internally configured to resiliently grip differently sized pipettes inserted therein at different locations along the length thereof. A stabilizing member is provided at the open distal end of the tubular nose. The stabilizing member is configured to radially confine and support pipettes received in the axial passageway of the resilient retainer.
Abstract translation: 用于将各种尺寸的移液管连接到移液器的空气通道的安装夹具包括具有固定到移液器的近端和开口远端的管状鼻。 弹性保持器将管状鼻部的内部排列。 保持器具有在其入口和出口开口处分别与管状鼻部的敞开的远端和移液管的空气通道连通的轴向通道。 通道在其入口处的最大直径处在其出口处的最小直径处逐渐变细。 入口开口的尺寸设计成轴向地容纳最大的移液管，并且套筒在内部构造成弹性地夹持沿其长度的不同位置插入的不同大小的移液管。 稳定构件设置在管状鼻部的开口远端。 稳定构件被构造成径向地限制并支撑容纳在弹性保持器的轴向通道中的移液管。
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公开(公告)号：US6107085A
公开(公告)日：2000-08-22
申请号：US110754
申请日：1998-07-03
Applicant: Paul Thomas Coughlin , George Frederick Lyman , Gregory Mathus
Inventor： Paul Thomas Coughlin , George Frederick Lyman , Gregory Mathus
Abstract: The present application relates generally to a system for the practice of high density cell culture. The system employs the use of two tanks; a cell growth tank having multiple cell growth chambers, is preferably situated within a reservoir tank. A series of pumps and outlets provide an even and continuous circulation of media and air to the system and between tanks. The system is designed to operate with minimal supervision and constantly over long periods of time.
Abstract translation: 本申请一般涉及用于实施高密度细胞培养的系统。 该系统使用两个坦克; 具有多个细胞生长室的细胞生长槽优选位于储存罐内。 一系列泵和出口提供均匀且连续的介质和空气循环到系统和罐之间。 该系统的设计是在最少的监督下持续运行。
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公开(公告)号：US5466602A
公开(公告)日：1995-11-14
申请号：US180695
申请日：1994-01-13
Applicant: George Lyman , Gregory Mathus , David Root
Inventor： George Lyman , Gregory Mathus , David Root
Abstract: The present invention relates to an apparatus for growing tissue culture in vitro. The apparatus features a housing which fits into a well containing media. A bottom membrane surface is maintained at a depth within the well, and the housing centered in the well by a flange and rim which cooperate with the well.
Abstract translation: 本发明涉及体外培养组织培养的装置。 该装置具有适合于容纳介质的容器的壳体。 底部膜表面保持在井内的深度，并且壳体通过与井配合的凸缘和边缘在井中居中。
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公开(公告)号：US5215920A
公开(公告)日：1993-06-01
申请号：US695300
申请日：1991-05-03
Applicant: George Lyman , Gregory Mathus , David Root
Inventor： George Lyman , Gregory Mathus , David Root
Abstract: Apparatus for growing tissue cultures in vitro, which permits a concentration gradient of nutrients to develop through a permeable membrane to which a sample of tissue is attached. The permeable membrane is attached to the bottom end of a tubular support that in turn hangs by a flange connected to its upper end on the top of a well containing the nutrients. Typically, the well is part of a tissue culture cluster dish. The flange of the support positions the support and membrane centrally in the well so as to avoid capillary action in the space between the well and support. The configuration of the support and its cooperation with the lid of the cluster dish also prevents the support and membrane from floating in the nutrient solution in the well. Openings in the support provide access for a pipette to add and withdraw fluid from the space between the well and membrane support and from the space below the membrane.
Abstract translation: 用于在体外生长组织培养物的装置，其允许营养物的浓度梯度通过附着有组织样品的渗透膜发育。 可渗透膜附接到管状支撑件的底端，管状支撑件的底端又通过连接到容纳营养物质的孔的顶部上方的凸缘而悬挂。 通常，孔是组织培养簇盘的一部分。 支撑件的凸缘将支撑件和膜中心定位在井中，以避免在井和支撑件之间的空间中的毛细作用。 支架的配置及其与簇盘盖的配合也可防止支撑和膜浮在井中的营养液中。 支架中的开口提供移液管的通道，以从孔和膜支撑之间的空间以及膜下方的空间添加和抽出流体。
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Patent Agency Ranking
公开(公告)号：US4927604A
公开(公告)日：1990-05-22
申请号：US280170
申请日：1988-12-05
Applicant: Gregory Mathus , George Lyman
Inventor： Gregory Mathus , George Lyman
CPC classification number: B01D61/18 , B01D29/05 , B01L3/50255 , Y10T436/255
Abstract: A filtration system for handling an array of filter wells which are open at the top and closed by a filter membrane at the bottom. The system includes a manifold chamber defined by side and bottom walls and having a support for the wells which carries the filter membranes above the bottom walls so that filtrate may be drawn through the membranes. A vacuum fitting is connected to the chamber so that a low pressure source may be applied thereto, and a sealing sheet extends over the wells and having holes aligned with the open tops of the wells so that when the low pressure is applied to the chamber, filtrate may be drawn through the membrane.
Abstract translation: 一个过滤系统，用于处理在顶部开放并由底部的过滤膜封闭的过滤器孔阵列。 该系统包括由侧壁和底壁限定的歧管室，并具有用于在底壁上方承载过滤膜的孔的支撑，使得滤液可以通过膜抽吸。 真空接头连接到腔室，以便可以向其施加低压源，并且密封片在井上延伸并且具有与孔的开口顶部对准的孔，使得当低压施加到腔室时， 滤液可以通过膜抽吸。
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公开(公告)号：US4824642A
公开(公告)日：1989-04-25
申请号：US921319
申请日：1986-10-21
Applicant: George Lyman , Gregory Mathus
Inventor： George Lyman , Gregory Mathus
CPC classification number: B01L3/0224 , G01N35/1065 , Y10S436/809
Abstract: A multi-channel pipetter has a U-shaped housing with horizontal upper and lower arms and an interconnecting hand grip portion. A plurality of nozzles that serve to support replaceable tips are mounted on the lower arm in a vertical orientation and are connected by a flexible tubing that extends upwardly through the grip portion to a circular array of cylinders disposed horizontally in the upper arm. A piston-cylinder-volume setting mechanism is horizontally disposed in the upper arm. The mechanism is actuated by a trigger on the hand grip portion and the volume is controlled by a micrometer head which operates a stop within the upper arm. A tip ejector is mounted in the lower arm which provides substantial mechanical advantage for stripping the tips from the nozzles.
Abstract translation: 多通道移液器具有U形壳体，其具有水平上臂和下臂以及互连的手柄部分。 用于支撑可替换的尖端的多个喷嘴以垂直取向安装在下臂上，并且通过柔性管连接，柔性管向上延伸穿过把手部分到水平放置在上臂中的圆形圆柱形阵列。 水平地设置在上臂中的活塞缸体积设定机构。 该机构由手握部分上的触发器致动，并且该体积由在上臂中操作停止的测微头来控制。 尖端喷射器安装在下臂中，其为从喷嘴剥离尖端提供了实质的机械优点。
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公开(公告)号：US4257524A
公开(公告)日：1981-03-24
申请号：US956050
申请日：1978-10-30
Applicant: Edward H. Yonkers , Alan Stenfors , Gregory Mathus
Inventor： Edward H. Yonkers , Alan Stenfors , Gregory Mathus
IPC: G11B23/023 , A47F7/00
CPC classification number: G11B23/0236
Abstract: A cassette storage rack having a tray-like base with dividers so as to orient the cassettes in their boxes uniformly in the rack. The cassette boxes are retained in the rack by means of a resilient foam block which engages one edge of each box and urges it against an opposite retaining wall.
Abstract translation: 一种盒式存储架，其具有带分隔件的托盘状基座，以便将盒子在其盒中均匀地定位在机架中。 盒式磁带盒通过与每个盒子的一个边缘接合的弹性泡沫块保持在机架中并将其推向相对的挡土墙。
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公开(公告)号：US4223787A
公开(公告)日：1980-09-23
申请号：US37488
申请日：1979-05-09
Applicant: Alan B. Lowry , David E. Roche , Gregory Mathus
Inventor： Alan B. Lowry , David E. Roche , Gregory Mathus
IPC: G11B23/023 , G11B23/02 , B65D85/672 , E05C1/10 , G11B1/00
CPC classification number: G11B23/0236 , Y10S292/38 , Y10T292/0969 , Y10T292/0997
Abstract: A cassette-carrying case having a base and cover joined by a piano hinge which allows the base and cover to be opened a full 180.degree.. Easily operable latches are incorporated into the cover, which automatically lock the case closed when the cover is moved to the closed position. A handle is incorporated into the main body of the base and cover.
Abstract translation: 一种带盒的盒子，具有通过钢琴铰链连接的底座和盖子，其允许底座和盖子打开180度。 易于操作的闩锁被并入到盖子中，当盖子移动到关闭位置时，其自动地将壳体关闭。 将手柄并入基座和盖子的主体内。
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公开(公告)号：USD254114S
公开(公告)日：1980-02-05
申请号：US837617
申请日：1977-09-28
Applicant: George Lyman , Gregory Mathus , Edward Yonkers
Designer： George Lyman , Gregory Mathus , Edward Yonkers
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