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    Syringe assembly for a drug delivery device and method of assembly
    52.
    发明授权
    Syringe assembly for a drug delivery device and method of assembly 有权

    公开(公告)号：US11590294B2

    公开(公告)日：2023-02-28

    申请号：US16609483

    申请日：2018-06-01

    Applicant: AMGEN INC.

    Inventor： Adam B. McCullough ,  Hans Stenberg Knudsen ,  Rasmus Øhlenschlæger

    IPC: A61M5/34 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32

    Abstract: A syringe assembly for a drug delivery device. The syringe assembly includes a syringe barrel having a proximal end, a distal end, and a longitudinal axis. A needle assembly is operatively coupled to the syringe barrel and includes a needle hub and a needle attached to the needle hub. A flexible connection is disposed between the syringe barrel and the needle hub and forms a fluid pathway between the syringe barrel and the needle. The flexible connection enables the needle assembly to be moveable from a filling position, in which a longitudinal axis of the needle assembly is parallel to a longitudinal axis of the syringe barrel, to an assembled position, in which the longitudinal axis of the needle assembly is not parallel to the longitudinal axis of the syringe barrel.

    Insertion mechanism and method of inserting a needle of a drug delivery device
    53.
    发明授权
    Insertion mechanism and method of inserting a needle of a drug delivery device 有权

    公开(公告)号：US11571511B2

    公开(公告)日：2023-02-07

    申请号：US16488466

    申请日：2018-02-20

    Applicant: AMGEN INC.

    Inventor： Adam B. McCullough

    IPC: A61M5/158 ,  A61M5/142

    Abstract: An insertion mechanism for a drug delivery device. The insertion mechanism includes a proximal end, a distal end, a first opening disposed near the proximal end, and a second opening disposed in the distal end. A needle or cannula assembly is disposed within a housing and has a base with a proximal surface and a distal surface and a needle or cannula coupled to the distal surface. A retraction member is disposed within the housing to maintain the needle or cannula assembly in a retracted position before movement to an extended position, the retraction member in contact with the base. Upon supplying pressure through the first opening until an amount of pressure P1 applies an application force to the proximal surface of the base that surpasses a resistive force of the retraction member, the needle or cannula assembly is moved from the retracted position to the extended position.

    SYSTEMS AND COMPONENTS FOR DRUG DELIVERY AND COMPONENTS FOR PREPARATION OF THE SAME
    54.
    发明申请
    SYSTEMS AND COMPONENTS FOR DRUG DELIVERY AND COMPONENTS FOR PREPARATION OF THE SAME 有权

    公开(公告)号：US20220378657A1

    公开(公告)日：2022-12-01

    申请号：US17770320

    申请日：2020-10-22

    Applicant: AMGEN INC.

    Inventor： Scott R. Gibson ,  Olivia Li ,  Nicholas J. Clark ,  Adam B. McCullough

    IPC: A61J1/20 ,  A61J1/14

    Abstract: A device for connecting tubes for a drug delivery system includes a connecting portion having a first tube channel, a second tube channel, a connecting heating element, and a carriage assembly. The first tube channel is adapted to receive a first tube, and the second tube channel is adapted to receive a second tube. The connecting heating element is positioned adjacent to and/or intersecting the first and second tube channels and is adapted to selectively heat at least a portion of the first and second tube. The carriage assembly moves the heated first and second tubes into end-to-end contact with each other to couple the first and second tubes together.

    DRUG DELIVERY DEVICE WITH LIVE BUTTON OR USER INTERFACE FIELD
    55.
    发明申请
    DRUG DELIVERY DEVICE WITH LIVE BUTTON OR USER INTERFACE FIELD 有权

    公开(公告)号：US20220273878A1

    公开(公告)日：2022-09-01

    申请号：US17745499

    申请日：2022-05-16

    Applicant: AMGEN INC.

    Inventor： Adam B. McCullough ,  Scott R. Gibson

    IPC: A61M5/24 ,  A61M5/142 ,  A61M5/32 ,  A61M5/145 ,  A61M5/20 ,  A61M5/315

    Abstract: A drug delivery device includes a container for storing a drug, the container having a stopper for expelling the drug; an injection drive comprising an energy source for directly or indirectly acting on the stopper to expel the drug; a sensor for detecting contact between the drug delivery device and a body of a patient; and a user interface (UI) for activating or causing the activation of the injection drive. The device is operative for drawing attention to the UI, if the sensor detects contact between the drug delivery device and the body of the patient, to thereby indicate that the injection drive is ready to be activated, which activation is the next step in the drug administration process.

    ACTIVATION MECHANISM FOR DRUG DELIVERY DEVICE
    56.
    发明申请
    ACTIVATION MECHANISM FOR DRUG DELIVERY DEVICE 有权

    公开(公告)号：US20210260302A1

    公开(公告)日：2021-08-26

    申请号：US17261648

    申请日：2019-08-16

    Applicant: AMGEN INC.

    Inventor： Matias Melander ,  Joshua Jay Dudman ,  Joseph Michael Iglesias ,  Bjarke Lykke Ludvig Svendsen ,  Adam B. McCullough ,  Christian Plambech ,  Steve Sanchez

    IPC: A61M5/315 ,  A61M5/32 ,  A61M5/20

    Abstract: A drug delivery device includes a housing, an injection assembly at least partially disposed in the housing, a shield, and a drive assembly at least partially disposed in the housing and coupled with the injection assembly and the shield. The shield has an extended position where at least a proximal end thereof extends a distance beyond a proximal end of the housing. The injection assembly includes a needle or cannula having an endpoint. Upon moving the shield axially towards the distal end of the housing a predetermined distance, a retraction profile commences whereby the drive assembly administers a medicament via the injection assembly. A peak resistance force is exerted within approximately the first 12 mm of axial movement of the shield.

    DRUG DELIVERY STORAGE DEVICE AND SYSTEM
    57.
    发明申请
    DRUG DELIVERY STORAGE DEVICE AND SYSTEM 审中-公开

    公开(公告)号：US20200289740A1

    公开(公告)日：2020-09-17

    申请号：US15775650

    申请日：2016-12-14

    Applicant: AMGEN INC.

    Inventor： Ferry Tamtoro ,  Huaying Yang ,  Scott Robert Gibson ,  Donald Busby ,  Peter V. Shultz ,  Basel Hasan Taha ,  Adam B. McCullough

    IPC: A61M5/00 ,  A61J7/04 ,  G16H20/17 ,  G16H40/63

    Abstract: A drug delivery system includes a storage container defining one or more storage compartments and having at least one container sensor coupled thereto, a container condition change mechanism coupled to the storage container for imparting a change on one or more conditions of the one or more storage compartments, at least one drug delivery device adapted to deliver a drug to a user and adapted to be at least partially disposed within one or more of the one or more storage compartments, at least one delivery device sensor, a delivery device condition change mechanism coupled to the drug delivery device, and a controller coupled to the storage container. The storage container may be adapted to hold a number of drug delivery devices within a number of sealable storage compartments. The container sensor is adapted to sense a condition of the storage container, and the delivery device sensor is adapted to sense a condition of the at least one drug delivery device. The controller is adapted to instruct the container condition change mechanism and/or the delivery device change mechanism to impart a change on at least one condition of the storage container and/or the drug delivery device.

    INSERTION MECHANISM AND METHOD OF INSERTING A NEEDLE OF A DRUG DELIVERY DEVICE
    58.
    发明申请
    INSERTION MECHANISM AND METHOD OF INSERTING A NEEDLE OF A DRUG DELIVERY DEVICE 审中-公开

    公开(公告)号：US20200238004A1

    公开(公告)日：2020-07-30

    申请号：US16488466

    申请日：2018-02-20

    Applicant: AMGEN INC.

    Inventor： Adam B. McCullough

    IPC: A61M5/158 ,  A61M5/142

    Abstract: An insertion mechanism for a drug delivery device. The insertion mechanism includes a proximal end, a distal end, a first opening disposed near the proximal end, and a second opening disposed in the distal end. A needle or cannula assembly is disposed within the housing and has a base with a proximal surface and a distal surface and a needle or cannula coupled to the distal surface. A retraction member is disposed within the housing to maintain the needle or cannula assembly in the retracted position before movement to the extended position, the retraction member in contact with the base. Upon supplying pressure through the first opening until an amount of pressure P1 applies an application force to the proximal surface of the base that surpasses a resistive force of the retraction member, the needle assembly is moved from the retracted position to the extended position.

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