公开(公告)号：US10012636B2

公开(公告)日：2018-07-03

申请号：US15651882

申请日：2017-07-17

Applicant: ACEA Biosciences, Inc.

Inventor： Xiaobo Wang ,  Yama A. Abassi ,  Biao Xi ,  Wen Fu Zhang ,  Xiao Xu

IPC: C40B30/06 ,  G01N7/00 ,  C12Q1/00 ,  G01N33/483

CPC classification number: G01N33/4836

Abstract: A system for monitoring impedance of excitable cells in vitro, which includes a device for monitoring cell-substrate impedance at 20 millisecond resolution, which includes a nonconductive substrate with one or more electrode arrays fabricated in one or more wells, wherein cell attachment on the substrate can result in a detectable change in impedance between electrodes within each electrode array; an impedance analyzer capable of impedance measurement at 20 millisecond time resolution; electronic circuitry that can engage said device and selectively connect said two or more electrode arrays of said device to said impedance analyzer; and a software program that controls said electronic circuitry and records and analyzes data obtained from said impedance analyzer.

公开(公告)号：US20180136107A1

公开(公告)日：2018-05-17

申请号：US15870661

申请日：2018-01-12

Applicant: ACEA Biosciences, Inc.

Inventor： Nan Li ,  Sean Lee ,  Kilo Vilayphone ,  Xiaobo Wang

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N2015/1006 ,  G01N2015/1486

Abstract: A method of collecting cells from individual wells of a multi-well plate for flow cytometry, the method comprising: determining particle or cell counts from each well of the multi-well plate by flow cytometry; ordering the wells from lowest particle count to highest particle count; generating a sequential order for collection that follows the ordering of wells to establish a collection pattern; and collecting particles or cells according to the collection pattern in a second multi-well plate by flow cytometry.

公开(公告)号：US09920074B2

公开(公告)日：2018-03-20

申请号：US15271124

申请日：2016-09-20

Applicant: ACEA BIOSCIENCES INC.

Inventor： Xiao Xu ,  Xiaobo Wang ,  Long Mao ,  Li Zhao ,  Biao Xi

IPC: C07D519/00 ,  C07D487/04 ,  C07D239/49 ,  C07D239/52 ,  C07D403/12 ,  C07D401/12 ,  C07D473/18 ,  C07D417/12 ,  C07D239/47 ,  C07D239/48

CPC classification number: C07D519/00 ,  C07D239/47 ,  C07D239/48 ,  C07D239/49 ,  C07D239/52 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D473/18 ,  C07D487/04

Abstract: The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.

公开(公告)号：US20170315122A1

公开(公告)日：2017-11-02

申请号：US15650896

申请日：2017-07-15

Applicant: ACEA Biosciences, Inc.

Inventor： Nan Li ,  Lingbo Kong ,  Jian Wu ,  Tingting Cheng ,  Yangde Qing ,  Xiaobo Wang

IPC: G01N33/569 ,  G01N15/14 ,  G01N15/10

CPC classification number: G01N33/56972 ,  G01N15/1434 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1438 ,  G01N2015/1477

Abstract: An optical engine its use in a bench top flow cytometer, the optical engine having a set of lasers, each focused horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same excitation plane of a flow cell, a set of optics that separate fluorescence of a same wavelength range into different locations in a focal plane of collection optics according to the different lasers by which the fluorescent light is excited; and a detector that selectively detects light from the different locations thereby distinguishing between fluorescence emitted within the same wavelength range as excited by the different lasers.

公开(公告)号：US08685988B2

公开(公告)日：2014-04-01

申请号：US13917514

申请日：2013-06-13

Applicant: ACEA Biosciences Inc.

Inventor： Xiao Xu ,  Xiaobo Wang ,  Long Mao ,  Li Zhao ,  Biao Xi

IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00

CPC classification number: A61K31/519 ,  A61K45/06 ,  C07D487/04 ,  A61K2300/00

Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.

Abstract translation: 本发明涉及某些吡咯并嘧啶衍生物，含有它们的药物组合物及其使用方法，包括治疗肿瘤的方法和与激酶失调相关的相关疾病（如EGFR（包括HER），Alk，PDGFR），但是 途径。