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    Novel disubstituted 4-hydroxyphenylthio anilides
    52.
    发明授权
    Novel disubstituted 4-hydroxyphenylthio anilides 失效
    新型二取代的4-羟基苯基硫代酰苯胺

    公开(公告)号：US5071876A

    公开(公告)日：1991-12-10

    申请号：US558965

    申请日：1990-07-27

    Applicant: Richard A. Mueller ,  Richard A. Partis ,  James R. Deason

    Inventor： Richard A. Mueller ,  Richard A. Partis ,  James R. Deason

    IPC: C07C317/44

    CPC classification number: C07C317/44 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/863 ,  Y10S514/886 ,  Y10S514/887

    Abstract: The compounds of this invention are anilides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is hydrogen or lower alkyl; and R.sub.4 is phenyl or substituted phenyl. The compounds of the present invention are useful in the treatment of inflammation, allergy and hypersensitivity reactions and other disorders of the immune system.

    Abstract translation: 本发明的化合物是由下式表示的酰苯胺：其中：R 1和R 2是由卤素，苯基，取代的苯基和取代的苯基和基团组成的组中相同或不同的成员，其中n，m和p是 独立地为1〜8的整数，条件是n + m + p等于或小于10; X是硫基，亚磺酰基或磺酰基; Alk是直链或支链低级亚烷基; R3是氢或低级烷基; 并且R 4是苯基或取代的苯基。 本发明的化合物可用于治疗炎症，过敏和超敏反应以及免疫系统的其它病症。

    Intermediates for antiviral compounds
    53.
    发明授权
    Intermediates for antiviral compounds 失效
    抗病毒化合物的中间体

    公开(公告)号：US4937357A

    公开(公告)日：1990-06-26

    申请号：US410638

    申请日：1989-09-26

    Applicant: Francis J. Koszyk ,  Richard A. Partis ,  Richard A. Mueller

    Inventor： Francis J. Koszyk ,  Richard A. Partis ,  Richard A. Mueller

    IPC: C07C43/166 ,  C07C45/40 ,  C07C47/277 ,  C07D207/12

    CPC classification number: C07D207/12 ,  C07C43/166 ,  C07C45/40 ,  C07C47/277

    Abstract: N-alkyl, N-hydroxylalkyl and N-alkanoyl derivatives of 1,4-dideoxy-1,4-imino-L-arabinitol are disclosed in which the alkyl group has from 4 to about 9 carbon atoms, the hydroxyalkyl group has from 2 to about 5 carbon atoms and the alkanoyl group has from 3 to about 12 carbon atoms. These compounds are useful intermediates for the preparation of acylated derivatives thereof which have antiviral activity.

    Abstract translation: 公开了1,4-二脱氧-1,4-亚氨基-L-阿拉伯糖醇的N-烷基，N-羟基烷基和N-烷酰基衍生物，其中烷基具有4至约9个碳原子，羟烷基具有2 至约5个碳原子，而烷酰基具有3至约12个碳原子。 这些化合物是制备其具有抗病毒活性的酰化衍生物的有用中间体。

    [Halo-4-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-phenyl]octadecan-ols and -ones
    56.
    发明授权
    [Halo-4-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-phenyl]octadecan-ols and -ones 失效
    [卤代-4-（4,5-二氢-4,4-二甲基-2-恶唑基） - 苯基]十八烷-2-酮和 - 酮

    公开(公告)号：US4501895A

    公开(公告)日：1985-02-26

    申请号：US627324

    申请日：1984-07-02

    Applicant: Richard A. Mueller ,  Richard A. Partis

    Inventor： Richard A. Mueller ,  Richard A. Partis

    IPC: C07C45/46 ,  C07C49/807 ,  C07C63/70 ,  C07C63/74 ,  C07C65/01 ,  C07C65/32 ,  C07D263/10 ,  C07D263/12 ,  C07D263/14

    CPC classification number: C07D263/10 ,  C07C45/46 ,  C07C49/807 ,  C07C65/01 ,  C07C65/32

    Abstract: This invention relates to novel compounds for preventing or retarding the degradation of elastin or other proteins and therefore preventing or retarding the disease states caused by said degradation, of the formula: ##STR1## or its pharmacologically acceptable salts. The invention also relates to novel methods and intermediates for making the compounds. The intermediate compound being of the formula: ##STR2## wherein R.sub.2 is (a) halogen; or(b) trifluoromethyl;wherein R.sub.3 is(a) --C(O)R.sub.4 ;(b) --CH(OH)R.sub.4 ;(c) --CH.sub.2 R 4; or(d) --CH.dbd.CHR.sub.4 ;wherein R.sub.4 is alkyl or 13 to 25 carbon atoms inclusive, and the pharmacologically acceptable base addition salts thereof.

    Abstract translation: 本发明涉及用于预防或延缓弹性蛋白或其它蛋白质降解并因此预防或延缓由所述降解引起的疾病状态的新颖化合物，其具有下式：其药理学上可接受的盐。 本发明还涉及制备该化合物的新方法和中间体。 中间体化合物具有下式：其中R 2是（a）卤素; 或（b）三氟甲基; 其中R 3是（a）-C（O）R 4; （b）-CH（OH）R 4; （c）-CH 2 R 4; 或（d）-CH = CHR 4; 其中R4是烷基或13-25个碳原子，包括其中的药理学上可接受的碱加成盐。

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