公开(公告)号：US20200053487A1

公开(公告)日：2020-02-13

申请号：US16598009

申请日：2019-10-10

申请人： ElectroCore, Inc.

发明人： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC分类号： H04R25/00

摘要： Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders.

公开(公告)号：US20200046973A1

公开(公告)日：2020-02-13

申请号：US16599285

申请日：2019-10-11

申请人： ElectroCore, Inc.

发明人： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC分类号： A61N1/36 ,  A61N2/00 ,  A61N2/02 ,  A61N1/04

摘要： Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The devices comprise a housing and an energy source for generating an electric current and transmitting the electric current from the electrode through an interface and the outer skin surface of the patient to a selected nerve fiber within the patient as the interface contacts the outer skin surface. The electric current is sufficient to modulate the selected nerve fiber to at least one of treat or prevent at least one of gastroparesis, functional dyspepsia, or ileus in the patient.

公开(公告)号：US20240316342A1

公开(公告)日：2024-09-26

申请号：US18595282

申请日：2024-03-04

申请人： ElectroCore, Inc.

发明人： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC分类号： A61N1/36 ,  A61B5/00 ,  A61N1/04 ,  A61N1/372 ,  A61N1/40 ,  A61N2/00 ,  A61N2/02 ,  G06Q10/10 ,  G16H20/30 ,  G16H20/40 ,  G16H40/20

CPC分类号： A61N1/36021 ,  A61N1/36034 ,  G06Q10/10 ,  G16H20/30 ,  G16H20/40 ,  G16H40/20 ,  A61B5/4836 ,  A61B2560/0456 ,  A61N1/0456 ,  A61N1/37235 ,  A61N1/40 ,  A61N2/006 ,  A61N2/008 ,  A61N2/02

摘要： Devices, systems, and methods are provided for treating various symptoms, disorders and medical conditions through noninvasive stimulation of a nerve. A system comprises a stimulator having an interface configured to contact an outer skin surface of a user and an energy source coupled to the interface. The energy source transmits an electrical signal comprising a plurality of electrical impulses through the interface transcutaneously through the outer skin surface of the user to a nerve of the user such that the nerve is modulated. The system further comprises a downloadable software application downloadable onto a mobile device configured for wireless coupling to the stimulator to transmit data from the software application to the stimulator. The downloadable software application controls a duration of time in which the stimulator generates the electrical signal.

公开(公告)号：US20240198086A1

公开(公告)日：2024-06-20

申请号：US18593513

申请日：2024-03-01

申请人： ElectroCore, Inc.

发明人： Bruce J. Simon ,  Joseph P. Errico

IPC分类号： A61N1/04 ,  A61N1/05 ,  A61N1/36 ,  A61N1/40 ,  A61N2/00 ,  A61N2/02

CPC分类号： A61N1/0456 ,  A61N1/04 ,  A61N1/0492 ,  A61N1/0551 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/36034 ,  A61N1/0472 ,  A61N1/36017 ,  A61N1/36114 ,  A61N1/40 ,  A61N2/006 ,  A61N2/008 ,  A61N2/02

摘要： Devices and methods are disclosed for treating one or more symptoms of a central nervous system disorder in a patient, such as fibromyalgia, anxiety, traumatic brain injury or post-traumatic stress disorder (PTSD). A device comprises one or more electrodes configured for contacting an outer skin surface of the patient and an energy source coupled to the electrodes. The energy source generates at least one electrical impulse and transmits the electrical impulse transcutaneously from the electrodes through the outer skin surface of the patient to a vagus nerve in the patient. The electrical impulse comprises a burst period and a constant period. Each burst period comprises 2 to 20 pulses that alternate between a positive and negative electric field charge and at least a portion of each constant period comprises zero pulses. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms of the disorder are reduced.

公开(公告)号：US11944807B2

公开(公告)日：2024-04-02

申请号：US17481510

申请日：2021-09-22

申请人： ELECTROCORE, INC

发明人： Bruce J. Simon ,  Joseph P. Errico

IPC分类号： A61N1/04 ,  A61N1/05 ,  A61N1/36 ,  A61N1/40 ,  A61N2/00 ,  A61N2/02

CPC分类号： A61N1/0456 ,  A61N1/04 ,  A61N1/0492 ,  A61N1/0551 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/36034 ,  A61N1/0472 ,  A61N1/36017 ,  A61N1/36114 ,  A61N1/40 ,  A61N2/006 ,  A61N2/008 ,  A61N2/02

摘要： Devices, systems and methods are disclosed for treating one or more symptoms of central nervous system disorders in a patient, such as anxiety disorders, fibromyalgia, traumatic brain injury, PTSD, and others. A method includes positioning a contact surface of a device in contact with an outer skin surface of patient and applying an electrical impulse transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient for about 90 seconds to about 3 minutes. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms of the central nervous system disorder are reduced. For chronic treatment of such disorders, a stimulation protocol is provided that includes two or more doses administered per day for a period of time sufficient to relieve the symptoms.

公开(公告)号：US20240058605A1

公开(公告)日：2024-02-22

申请号：US18386242

申请日：2023-11-01

申请人： ElectroCore, Inc.

发明人： Joseph P. Errico ,  Steven Mendez ,  Bruce J. Simon

IPC分类号： A61N1/36 ,  A61N1/04 ,  A61N1/372 ,  A61N1/375 ,  A61N1/378 ,  H04M1/21

CPC分类号： A61N1/36021 ,  A61N1/0456 ,  A61N1/36025 ,  A61N1/3603 ,  A61N1/36034 ,  A61N1/37217 ,  A61N1/3756 ,  A61N1/3787 ,  H04M1/21 ,  A61B5/6898

摘要： Systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache and trigeminal neuralgia and the like. The system comprises a stimulator configured for wireless coupling to a mobile device and comprising a signal generator that generates an electrical impulse and an energy source. The stimulator includes a contact surface configured to contact an outer skin surface of a head of a patient and a user interface for selecting a therapy regimen. The stimulator transmits the electrical impulse transcutaneously through the outer skin surface to a nerve at a target region of the head, wherein the electrical impulse is sufficient to modulate the nerve and modify the medical condition. The system further comprises a software program downloadable onto the mobile device and configured to communicate with the stimulator.

公开(公告)号：US11850056B2

公开(公告)日：2023-12-26

申请号：US17874364

申请日：2022-07-27

申请人： ELECTROCORE, INC

发明人： Bruce J. Simon ,  Joseph P. Errico

IPC分类号： A61B5/394 ,  A61N1/36 ,  A61B5/00 ,  A61B5/024 ,  A61B90/00 ,  A61N1/40

CPC分类号： A61B5/394 ,  A61B5/4035 ,  A61B5/4041 ,  A61B5/4803 ,  A61B5/4836 ,  A61B5/7264 ,  A61B5/7267 ,  A61N1/36021 ,  A61N1/36031 ,  A61N1/36034 ,  A61B5/02405 ,  A61B5/687 ,  A61B2090/3941 ,  A61N1/40

摘要： Systems and methods for remote therapy and patient monitoring are provided. A method comprises contacting an outer skin surface of a patient with a contact surface of a stimulator and transmitting an electrical impulse from the stimulator transcutaneously through the outer skin surface to a nerve within the patient. Data related to parameters of the electrical impulse applied to the nerve is stored and transmitted to a remote source. The data may include duration of treatment, amplitude of the electrical impulse, compliance with a prescribed therapy regimen or other relevant data related to the therapy. The method may further include collecting patient status data, such as symptoms of a medical condition (e.g., severity of a headache) before, during and/or after stimulation. The patient status data is correlated with the treatment data to monitor compliance and/or the effectiveness of the therapy.

公开(公告)号：US20230277844A1

公开(公告)日：2023-09-07

申请号：US18196491

申请日：2023-05-12

申请人： ElectroCore, Inc.

发明人： Joseph P. Errico ,  Arthur F. Ross ,  Muhammad Basit Qari

IPC分类号： A61N1/36 ,  G16H40/63 ,  G16H10/65 ,  G16H40/40 ,  G16H20/10 ,  A61N1/02 ,  G06K7/14 ,  G06K7/10 ,  A61N1/04 ,  G16H20/30

CPC分类号： A61N1/36034 ,  G16H40/63 ,  G16H10/65 ,  G16H40/40 ,  G16H20/10 ,  A61N1/025 ,  G06K7/1413 ,  G06K7/1417 ,  G06K7/10366 ,  A61N1/0456 ,  G16H20/30

摘要： A system is provided that includes a medical device comprising a power supply, a signal generator and an electrode. The signal generator is configured to apply one or more electrical impulses to the electrode for a period of time defined as a single dose. The system further comprises a processor coupled to the medical device. The processor is configured to switch the medical device from an activated mode to a deactivated mode after a specific number of single doses have been applied by the signal generator.

公开(公告)号：US11701515B2

公开(公告)日：2023-07-18

申请号：US17694655

申请日：2022-03-14

申请人： ELECTROCORE, INC

发明人： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC分类号： A61N1/36 ,  G16H20/30 ,  G06Q10/10 ,  G16H20/40 ,  G16H40/20 ,  A61N1/372 ,  A61N1/04 ,  A61N1/40 ,  A61N2/00 ,  A61N2/02 ,  A61B5/00

CPC分类号： A61N1/36021 ,  A61N1/36034 ,  G06Q10/10 ,  G16H20/30 ,  G16H20/40 ,  G16H40/20 ,  A61B5/4836 ,  A61B2560/0456 ,  A61N1/0456 ,  A61N1/37235 ,  A61N1/40 ,  A61N2/006 ,  A61N2/008 ,  A61N2/02

摘要： Devices, systems and methods for treating various disorders and medical conditions through noninvasive stimulation of a nerve. A system comprises a stimulator including an electrode configured to contact an outer skin surface of a patient and an energy source coupled to the housing, The energy source generates an electrical impulse and the stimulator transmits the electrical impulse from the electrode transcutaneously through an outer skin surface of the patient to a selected nerve within the patient. The system further includes an application on a mobile device that receives data from a remote source. The mobile device couples to the stimulator and the application causes the mobile device to transmit the data to the stimulator.

公开(公告)号：US11654277B2

公开(公告)日：2023-05-23

申请号：US17739100

申请日：2022-05-07

申请人： ELECTROCORE, INC

发明人： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

IPC分类号： A61N1/04 ,  A61N1/362 ,  A61N1/36 ,  A61N1/375 ,  A61N2/00 ,  A61N2/02

CPC分类号： A61N1/0456 ,  A61N1/362 ,  A61N1/36014 ,  A61N1/3625 ,  A61N1/36034 ,  A61N1/36062 ,  A61N1/375 ,  A61N2/006 ,  A61N2/02 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/36171 ,  A61N1/36178

摘要： Systems and methods for treating diseases and disorders in a patient are provided. A device comprises a stimulator comprising an electrode and an energy source. The energy source is configured to generate an electrical impulse and transmit the electrical impulse to the electrode through an outer skin surface to a vagus nerve of the patient. The device further comprises a sensor for detecting a physiological parameter of a patient's heart and a controller coupled to the stimulator and the sensor and configured to activate the stimulator based on the physiological parameter to cause the stimulator to generate the electrical impulse. In some aspects, the electrical impulse is sufficient to modulate the vagus nerve to treat a cardiac arrhythmia of the patient.