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102 条记录 (耗时 0.026 秒)

    Adapter for finger appendage of brass instrument
    51.
    发明授权
    Adapter for finger appendage of brass instrument 审中-公开

    公开(公告)号：US10672369B2

    公开(公告)日：2020-06-02

    申请号：US16416998

    申请日：2019-05-20

    申请人： Wichita State University

    发明人： John Hunsicker

    IPC分类号： G10D7/10 ,  G10D9/04

    摘要： An adapter for the finger appendage of a brass instrument has an adapter body. An outboard side and an inboard side of the adapter body are spaced apart along a width. The adapter includes a fitting portion defining the outboard side of the adapter body and a spacer portion defining the inboard side of the adapter body. The fitting portion defines a mounting opening configured to receive the first portion of the adapter body to mount the adapter body on the finger appendage such that the spacer portion is received in the finger gap and the inboard side of the adapter body opposes the second portion of the finger appendage to define a reduced gap having a width that is less than the width of the finger gap.

    Beacon-based indoor wayfinding system with automated beacon placement
    52.
    发明授权
    Beacon-based indoor wayfinding system with automated beacon placement 有权

    公开(公告)号：US10655970B2

    公开(公告)日：2020-05-19

    申请号：US16123659

    申请日：2018-09-06

    申请人： Wichita State University

    发明人： Vinod Namboodiri ,  Seyed Ali Cheraghi

    IPC分类号： G01C21/20 ,  G06K9/00 ,  H04W4/80 ,  G06T7/11 ,  G06T7/194 ,  G06F30/13 ,  G06F30/18 ,  H04W4/02 ,  H04W4/33 ,  G06K9/46

    摘要： An automated process designs an indoor wayfinding system using wireless beacons interacting with a mobile smartphone to guide a user to a destination. Image processing and computational geometric techniques extracting necessary information about an indoor space to determine beacon placement and support path computations for navigation. An architectural floor plan of the indoor space of interest is scanned to extract all the points of interest (doors, stairs, elevators, etc.), to identify walking paths within this space, and to create a connectivity graph representation of the space upon which path computations for navigation can be performed. Optimized locations where beacons should be placed on the indoor floor plan are identified very quickly and with minimal effort.

    Apparatus and method for simulating machining and other forming operations
    54.
    发明授权
    Apparatus and method for simulating machining and other forming operations 有权

    公开(公告)号：US09934339B2

    公开(公告)日：2018-04-03

    申请号：US14461164

    申请日：2014-08-15

    申请人： Viswanathan Madhavan

    发明人： Viswanathan Madhavan

    IPC分类号： G05B19/4097 ,  G06F17/50

    CPC分类号： G06F17/5009 ,  G05B19/4097

    摘要： A method includes obtaining information associated with a forming operation involving a manufacturing machine having a tool that contacts material. The method also includes simulating deformation of the material based on the information. Simulating the deformation of the material includes using discontinuity layout optimization to evaluate combinations of shear planes within an initial structure of the material, predict a mode of deformation comprising one or more of the shear planes along which the initial structure of the material will likely deform, and calculate a deformed shape of the material after an increment of deformation along the predicted mode of deformation. Simulating the deformation of the material also includes repeating the discontinuity layout optimization with the deformed shape of the material as the initial structure.

    END EFFECTOR FOR FORMING SWEPT FRICTION STIR SPOT WELDS
    57.
    发明申请
    END EFFECTOR FOR FORMING SWEPT FRICTION STIR SPOT WELDS 有权
    用于形成快速摩擦的终点效应

    公开(公告)号：US20130341375A1

    公开(公告)日：2013-12-26

    申请号：US13869165

    申请日：2013-04-24

    申请人： Wichita State University

    发明人： Dwight A. Burford

    IPC分类号： B23K20/12

    CPC分类号： B23K20/1245 ,  B23K20/1265

    摘要： An apparatus includes a connector and is configured to mount to a machine having multiple axes of control. A control signal on the connector determines a path of a rotating tool holder.

    摘要翻译： 一种装置包括连接器，并被配置为安装到具有多个控制轴的机器上。 连接器上的控制信号确定旋转刀架的路径。

    Protective Antigen Having Fluorinated Histidine Residues
    60.
    发明申请
    Protective Antigen Having Fluorinated Histidine Residues 有权
    具有氟化组氨酸残基的保护性抗原

    公开(公告)号：US20090123458A1

    公开(公告)日：2009-05-14

    申请号：US11939249

    申请日：2007-11-13

    申请人： James G. Bann

    发明人： James G. Bann

    IPC分类号： A61K39/00 ,  C07K14/00 ,  A61K39/395 ,  C12N5/06 ,  A61P43/00

    CPC分类号： C07K14/32 ,  A61K39/00

    摘要： The unnatural amino acid analogue 2-fluorohistidine (2-FHis) was incorporated into protective antigen to produce a protein which resists protonation at physiological pH by reducing the side-chain pKa. The protein structure was unperturbed by the incorporation of fluorinated histidine residues, and the heptameric (2-FHisPA63)7 could form ion conducting channels, and bind to the PA-binding domain of LF (LFN), but translocation of LFN in planar lipid bilayers was blocked. Further, while (2-FHisPA63)7 could bind to host cells and in vitro to the host cellular receptor, pore formation in the presence of the receptor was blocked, and LFN-DTA mediated cytotoxicity in CHO-K1 cells was blocked. The modified PA is useful as both a vaccine and an antitoxin, providing epitopes for the production of antibodies against PA, but preventing key steps in pathogenesis (pore formation, translocation).

    摘要翻译： 将非天然氨基酸类似物2-氟组氨酸（2-FHis）掺入保护性抗原中以产生通过减少侧链pKa在生理pH下抵抗质子化的蛋白质。 蛋白质结构通过引入氟化组氨酸残基而不受干扰，七聚体（2-FHisPA63）7可以形成离子传导通道，并结合LF（LFN）的PA结合结构域，但在平面脂双层中易位的LFN 被封锁。 此外，尽管（2-FHisPA63）7可以结合宿主细胞并且体外结合宿主细胞受体，但在受体存在下的孔形成被阻断，并且阻断了CHO-K1细胞中的LFN-DTA介导的细胞毒性。 修饰的PA可用作疫苗和抗毒素，提供用于产生针对PA的抗体的表位，但是防止发病机理中的关键步骤（孔形成，易位）。