Process for the production of 4-aminobutyric acid or its derivatives
    41.
    发明授权
    Process for the production of 4-aminobutyric acid or its derivatives 失效
    生产4-氨基丁酸或其衍生物的方法

    公开(公告)号:US4290972A

    公开(公告)日:1981-09-22

    申请号:US92940

    申请日:1979-11-09

    CPC分类号: C07C255/00 Y02P20/55

    摘要: 4-Amino-2-hydroxybutyric acid or 2,4-diaminobutyric acid may be readily produced by a new process comprising reacting a propionic acid compound containing a .beta.-carboxamido substituent (-CONH.sub.2) on the carbon atom at the 3-position and optionally containing hydroxyl substituent and protected or unprotected amino substituent on the .alpha.-carbon atom thereof, with an alkanoic acid anhydride in liquid pyridine to convert the carboxamido group into a nitrile group, with occasional acylation of a .alpha.-hydroxyl group, occasionally removing the alkanoyl group from the .alpha.-acyloxyl group of the resulting nitrile intermediate, and then reducing the resultant nitrile compound with hydrogen to convert the nitrile group into an aminomethyl group, and further optionally removing the residual amino-protecting group from the resultant 4-aminobutyric acid compound.

    摘要翻译: 4-氨基-2-羟基丁酸或2,4-二氨基丁酸可以通过一种新方法容易地产生,包括使含有β-羧酰胺基取代基(-CONH 2)的丙酸化合物在3-位上的碳原子上和任选地 在其α-碳原子上含有羟基取代基和被保护或未被保护的氨基取代基,与链烷酸酐在液体吡啶中,将羧酰胺基转化为腈基,偶尔酰化α-羟基,偶尔除去烷酰基 由得到的腈中间体的α-酰氧基,然后用氢还原得到的腈化合物,将腈基转化为氨基甲基,进一步任选地从所得的4-氨基丁酸化合物中除去残留的氨基保护基。

    Process for the manufacture of 1,4-diaminoanthraquinone-2-carboxylic acid
    42.
    发明授权
    Process for the manufacture of 1,4-diaminoanthraquinone-2-carboxylic acid 失效
    1,4-二氨基蒽醌-2-羧酸的制备方法

    公开(公告)号:US4243600A

    公开(公告)日:1981-01-06

    申请号:US33405

    申请日:1979-04-26

    CPC分类号: C09B1/22

    摘要: A process for the manufacture of 1,4-diaminoanthraquinone-2-carboxylic acid, which comprises reacting 1-nitroanthraquinone-2-carboxylic acid or derivatives thereof with hydroxylamine or derivatives thereof, in alcohol/water mixtures at basic value pH values.

    摘要翻译: 一种制备1,4-二氨基蒽醌-2-羧酸的方法,其包括使1-硝基蒽醌-2-羧酸或其衍生物与羟胺或其衍生物在碱性pH值的醇/水混合物中反应。

    Process for the production of carnitine
    45.
    发明授权
    Process for the production of carnitine 失效
    肉碱生产工艺

    公开(公告)号:US3969406A

    公开(公告)日:1976-07-13

    申请号:US572316

    申请日:1975-04-28

    申请人: Leander Tenud

    发明人: Leander Tenud

    CPC分类号: C07C229/22

    摘要: The process for the production of carnitine hydrochloride which includes reacting a .alpha.-haloacetoacetanilide having the formula:XCH.sub.2 COCH.sub.2 CONYC.sub.6 H.sub.5where X is a halogen atom and Y is a hydrogen atom, a phenyl group, a benzyl group or an alkyl group having 1 to 8 carbon atoms, with trimethylamine, a .gamma.-trimethylammonium acetoacetanilide halide resulting. The .gamma.-trimethylammonium acetoacetanilide halide, is hydrogenated, a .gamma.-trimethylammonium-.beta.-hydroxybutyric acid halide resulting. The .gamma.-trimethylammonium-.beta.-hydroxybutyric acid halide is converted by means of aqueous hydrochloric acid into the carnitine hydrochloride.

    摘要翻译: 用于生产盐酸左旋肉碱的方法,其包括使具有下式的α-卤代乙酰乙酰替苯胺

    Process for preparing esters of omega-aminododecanoic acid
    46.
    发明授权
    Process for preparing esters of omega-aminododecanoic acid 失效
    制备ω-氨基十二烷酸酯的方法

    公开(公告)号:US3883586A

    公开(公告)日:1975-05-13

    申请号:US44288374

    申请日:1974-02-15

    CPC分类号: C07C215/40

    摘要: omega -Aminododecanoic acid esters having the formula H2N(CH2)11COOR3 wherein R3 represents a saturated C1-4 alkyl group are prepared by reacting an omega -nitrocarboxylic acid ester having the formula O2N-(CH2)3-R1-(CH2)2-R2-(CH2)2COOR3 wherein R1 and R2 are both -CH2-CH2- or -CH CH-, or R1 is -CH2CH2- when R2 is -CH CH- or R1 is -CH CH- when R2 is -CH2CH2-, and R3 represents a saturated C1-4 alkyl group, with hydrogen in a hydrocarbon solvent in the presence of a palladium, platinum or nickel hydrogenation catalyst.

    摘要翻译: 通过使具有式O 2 N-(CH 2)3-R 1 - (CH 2)2的ω-硝基羧酸酯反应制备具有式H2N-(CH2)11COOR3的ω-十二烷酸酯,其中R 3表示饱和C 1-4烷基 -R 2 - (CH 2)2 COOR 3,其中R 1和R 2均为-CH 2 -CH 2 - 或-CH = CH-,或者当R 2为-CH = CH-或R 1为-CH 2 CH 2 - 或R 2为-CH = CH-时,R 2为 -CH 2 CH 2 - ,R 3表示饱和的C 1-4烷基,在烃溶剂中,在钯,铂或镍氢化催化剂的存在下用氢气。

    METHOD FOR PHOTOCLEAVAGE OF AMIDE BONDS

    公开(公告)号:US20220289665A1

    公开(公告)日:2022-09-15

    申请号:US17486807

    申请日:2021-09-27

    摘要: The present disclosure provides a method for photocleavage of an amide bond, the method has mild reaction conditions and can realize the cleavage of amide bonds by using light. The method comprises the following steps: subjecting 2,4-dinitrofluorobenzene to a reaction with an amino group of a substance represented by structural formula I with an α-amino acid at the end to produce a compound 1 represented by structural formula II; then under light irradiation, subjecting the compound 1 to a cleavage reaction of amide bond; Wherein, R1 is the side chain group of α-amino acid; R2 is: aryl, aliphatic hydrocarbon, —CH(R)—COOH or polypeptide.

    Diamine compound, and polyimide compound and molded product using the same

    公开(公告)号:US11136286B2

    公开(公告)日:2021-10-05

    申请号:US16868657

    申请日:2020-05-07

    摘要: [Problems to be solved] The present invention provides a novel diamine compound which allows for the synthesis of a polyimide compound having a high solubility in an organic solvent and a high melt moldability.
    [Solution] The diamine compound according to the present invention is characterized by being represented by the following general formula (1): (wherein R1 to R8 are each independently selected from the group consisting of a hydrogen atom, a fluorine atom, a substituted or unsubstituted alkyl group, and a substituted or unsubstituted aromatic group; and at least one of R1 to R8 is a substituted or unsubstituted aromatic group).