摘要:
4-Amino-2-hydroxybutyric acid or 2,4-diaminobutyric acid may be readily produced by a new process comprising reacting a propionic acid compound containing a .beta.-carboxamido substituent (-CONH.sub.2) on the carbon atom at the 3-position and optionally containing hydroxyl substituent and protected or unprotected amino substituent on the .alpha.-carbon atom thereof, with an alkanoic acid anhydride in liquid pyridine to convert the carboxamido group into a nitrile group, with occasional acylation of a .alpha.-hydroxyl group, occasionally removing the alkanoyl group from the .alpha.-acyloxyl group of the resulting nitrile intermediate, and then reducing the resultant nitrile compound with hydrogen to convert the nitrile group into an aminomethyl group, and further optionally removing the residual amino-protecting group from the resultant 4-aminobutyric acid compound.
摘要:
A process for the manufacture of 1,4-diaminoanthraquinone-2-carboxylic acid, which comprises reacting 1-nitroanthraquinone-2-carboxylic acid or derivatives thereof with hydroxylamine or derivatives thereof, in alcohol/water mixtures at basic value pH values.
摘要:
A derivative of paraphenylenediamine, for use as a color developer, having a primary amino group available for oxidative coupling, and a carboxy group bound to the benzene ring to provide the compound with the required stability to enable the compound to be incorporated into a photographic film, the compound being non-diffusible during development of the photographic film in an alkaline processing solution.
摘要:
A process for the manufacture of .alpha.,.alpha.'-aminonitroanthraquinones, from .alpha.,.alpha.'-dinitroanthraquinones, wherein the .alpha.,.alpha.'-dinitroanthraquinones are reacted with ammonia in dipolar aprotic solvents which are inert to ammonia, the reaction substrates and reaction products.
摘要:
The process for the production of carnitine hydrochloride which includes reacting a .alpha.-haloacetoacetanilide having the formula:XCH.sub.2 COCH.sub.2 CONYC.sub.6 H.sub.5where X is a halogen atom and Y is a hydrogen atom, a phenyl group, a benzyl group or an alkyl group having 1 to 8 carbon atoms, with trimethylamine, a .gamma.-trimethylammonium acetoacetanilide halide resulting. The .gamma.-trimethylammonium acetoacetanilide halide, is hydrogenated, a .gamma.-trimethylammonium-.beta.-hydroxybutyric acid halide resulting. The .gamma.-trimethylammonium-.beta.-hydroxybutyric acid halide is converted by means of aqueous hydrochloric acid into the carnitine hydrochloride.
摘要:
omega -Aminododecanoic acid esters having the formula H2N(CH2)11COOR3 wherein R3 represents a saturated C1-4 alkyl group are prepared by reacting an omega -nitrocarboxylic acid ester having the formula O2N-(CH2)3-R1-(CH2)2-R2-(CH2)2COOR3 wherein R1 and R2 are both -CH2-CH2- or -CH CH-, or R1 is -CH2CH2- when R2 is -CH CH- or R1 is -CH CH- when R2 is -CH2CH2-, and R3 represents a saturated C1-4 alkyl group, with hydrogen in a hydrocarbon solvent in the presence of a palladium, platinum or nickel hydrogenation catalyst.
摘要:
7-(O-AMINOMETHYLPHENYLACETAMIDO)-3-(TETRAZOLO(4,5-B)PYRIDAZIN-6 -YLTHIOMETHYL)-3-CEPHEM-CARBOXYLIC ACID AND ITS NONTOXIC, PHARMACEUTICALLY ACCEPTABLE SALTS AND ESPECIALLY ITS DIMETHANESULFONATE DERIVATIVE ARE VALUEABLE AS ANTIBACTERIA AGENTS, AS NUTRITIONAL SUPPLEMENTS IN ANIMAL FEEDS AND AS THERAPEUTICAL AGENTS IN POULTRY AND ANIMALS, INCLUDING MAN, AND ARE ESPECIALLY USEFUL IN THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY MANY GRAMPOSITIVE AND GRAM-NEGATIVE BACTERIA. 7-(O-AMINOMETHYLPHENYLACETAMIDO)-3-TETRAZOLO(4,5-B)PYRIDAZIN-6-YLTHIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACID IS PREPARED, FOR EXAMPLE, BY TREATMENT AT 0*C. WITH TRIFLUOROACETIC ACID OF THE CORRESPONDING COMPOUND IN WHICH THE FREE AMINO GROUP IS PROTECTED WITH A TERT-BUTOXYCARBONYL GROUP.
摘要:
The present disclosure provides a method for photocleavage of an amide bond, the method has mild reaction conditions and can realize the cleavage of amide bonds by using light. The method comprises the following steps: subjecting 2,4-dinitrofluorobenzene to a reaction with an amino group of a substance represented by structural formula I with an α-amino acid at the end to produce a compound 1 represented by structural formula II; then under light irradiation, subjecting the compound 1 to a cleavage reaction of amide bond; Wherein, R1 is the side chain group of α-amino acid; R2 is: aryl, aliphatic hydrocarbon, —CH(R)—COOH or polypeptide.
摘要:
[Problems to be solved] The present invention provides a novel diamine compound which allows for the synthesis of a polyimide compound having a high solubility in an organic solvent and a high melt moldability. [Solution] The diamine compound according to the present invention is characterized by being represented by the following general formula (1): (wherein R1 to R8 are each independently selected from the group consisting of a hydrogen atom, a fluorine atom, a substituted or unsubstituted alkyl group, and a substituted or unsubstituted aromatic group; and at least one of R1 to R8 is a substituted or unsubstituted aromatic group).
摘要:
Disclosed herein are compounds of the general Formula (I), and methods of synthesizing substituted bicyclo[1.1.1 jpentanes. The synthetic methods described herein use a [1.1.1]propellane, a Group VIII transition metal compound, a hydride source and a reagent that can contribute a substituent to form a substituted bicyclo[1.1.1]pentane, such as a compound of the general Formula (I).