公开(公告)号：US20220289665A1

公开(公告)日：2022-09-15

申请号：US17486807

申请日：2021-09-27

申请人： NANJING TECH UNIVERSITY

发明人： Xiaoqiang CHEN ,  Tingwen WEI ,  Jing WANG ,  Yanyan WANG

IPC分类号： C07C227/04 ,  C07D235/22 ,  C07D403/06 ,  C07D209/20

摘要： The present disclosure provides a method for photocleavage of an amide bond, the method has mild reaction conditions and can realize the cleavage of amide bonds by using light. The method comprises the following steps: subjecting 2,4-dinitrofluorobenzene to a reaction with an amino group of a substance represented by structural formula I with an α-amino acid at the end to produce a compound 1 represented by structural formula II; then under light irradiation, subjecting the compound 1 to a cleavage reaction of amide bond; Wherein, R1 is the side chain group of α-amino acid; R2 is: aryl, aliphatic hydrocarbon, —CH(R)—COOH or polypeptide.