公开(公告)号：US09754772B2

公开(公告)日：2017-09-05

申请号：US15253344

申请日：2016-08-31

Applicant: CANON KABUSHIKI KAISHA

Inventor： Kota Iwasaki ,  Hiroyuki Hashimoto

IPC: H01J49/00 ,  H01J49/16 ,  H01J49/06 ,  H01J37/244 ,  H01J37/12 ,  H01J37/141 ,  H01J49/14

CPC classification number: H01J49/0004 ,  H01J37/12 ,  H01J37/141 ,  H01J37/244 ,  H01J49/06 ,  H01J49/142 ,  H01J49/161 ,  H01J2237/226

Abstract: A charged particle image measuring device includes a sample stage, a charged particle lens opposite the sample stage, a two-dimensional detector, a first diaphragm disposed between the sample stage and a position of a crossover that is formed by the charged particle lens and that is closest to a sample, and a second diaphragm disposed between the first diaphragm and the two-dimensional detector.

公开(公告)号：US20170140913A1

公开(公告)日：2017-05-18

申请号：US14942743

申请日：2015-11-16

Applicant: Thermo Finnigan LLC

Inventor： James M. HITCHCOCK ,  Scott T. QUARMBY

IPC: H01J49/10 ,  G01N30/72

CPC classification number: H01J49/162 ,  G01N30/7206 ,  H01J49/161

Abstract: An ion source for a mass spectrometer comprises: an evacuated chamber having an interior receiving a gaseous sample effluent stream; a source of light pulses of pulse width 150 femtoseconds or less; a window of the evacuated chamber through which the light pulses pass into the evacuated chamber interior; one or more mirrors within the evacuated chamber disposed such that the light pulses are reflected from each of the one or mirrors such that the reflected pulses are caused to focus at one or more focal regions within the effluent stream within the evacuated chamber interior; and a pair of electrodes disposed at opposite sides of the one or more focal regions.

公开(公告)号：US20170085053A1

公开(公告)日：2017-03-23

申请号：US15364946

申请日：2016-11-30

Applicant: IMRA AMERICA, INC.

Inventor： Martin FERMANN

IPC: H01S3/11 ,  H01S3/0941 ,  H01S3/109 ,  H01S3/094 ,  H01S3/067

CPC classification number: H01S3/10046 ,  B23K26/0624 ,  H01J49/161 ,  H01S3/0057 ,  H01S3/06708 ,  H01S3/06725 ,  H01S3/06741 ,  H01S3/0675 ,  H01S3/06754 ,  H01S3/08013 ,  H01S3/094003 ,  H01S3/094026 ,  H01S3/094042 ,  H01S3/094061 ,  H01S3/0941 ,  H01S3/109 ,  H01S3/1106 ,  H01S3/1115

Abstract: The present invention relates to compact, low noise, ultra-short pulse sources based on fiber amplifiers, and various applications thereof. At least one implementation includes an optical amplification system having a fiber laser seed source producing seed pulses at a repetition rate corresponding to the fiber laser cavity round trip time. A nonlinear pulse transformer, comprising a fiber length greater than about 10 m, receives a seed pulse at its input and produces a spectrally broadened output pulse at its output, the output pulse having a spectral bandwidth which is more than 1.5 times a spectral bandwidth of a seed pulse. A fiber power amplifier receives and amplifies spectrally broadened output pulses. A pulse compressor is configured to temporally compress spectrally broadened pulses amplified by said power amplifier. Applications include micro-machining, ophthalmology, molecular desorption or ionization, mass-spectroscopy, and/or laser-based, biological tissue processing.

公开(公告)号：US20170074885A1

公开(公告)日：2017-03-16

申请号：US15309063

申请日：2015-05-05

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Hilton KOBUS ,  Taryn GUINAN ,  Nicolas H. VOELCKER ,  Ove Johan Ragnar GUSTAFSSON ,  Hazem Hussein Soliman ABDELMAKSOUD

IPC: G01N33/58 ,  A61B5/1172 ,  G01N21/64 ,  G01N33/94 ,  G06K9/00

CPC classification number: G01N33/585 ,  A61B5/1171 ,  A61B5/1172 ,  C01B33/02 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G01N33/94 ,  G01N2021/6439 ,  G06K9/00006 ,  G06K9/00013 ,  H01J49/161

Abstract: The present disclosure provides methods for detecting biological print(s) or biological fluid(s) or target low molecular weight analyte(s) therein comprising contacting the suspected print(s) or fluid(s) with porous semiconductor substrates or microparticles (MPs) under conditions to allow said semiconductor substrates or microparticles to adhere to the print(s) or fluid(s) or analyte(s) therein, and analysing the adhered porous semiconductor substrates or MPs to detect the print(s), fluid(s) or analytes when present. The disclosure also includes method for making porous semiconductor substrates.

Abstract translation: 本公开提供了用于检测其中的生物印刷品或生物流体或目标低分子量分析物的方法，其包括将可疑印刷物或流体与多孔半导体衬底或微粒（MP）接触， 在允许所述半导体衬底或微粒粘附到其中的印刷物或其分析物的条件下，并且分析粘附的多孔半导体衬底或MP以检测印刷物， 或分析物。 本公开还包括制造多孔半导体衬底的方法。

公开(公告)号：US09299552B2

公开(公告)日：2016-03-29

申请号：US14640766

申请日：2015-03-06

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Toma Yorisaki

IPC: H01J49/26 ,  H01J49/16 ,  H01J49/04 ,  H01J49/06

CPC classification number: H01J49/161 ,  H01J49/0409 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/0486 ,  H01J49/06 ,  H01J49/162

Abstract: A sputter neutral particle mass spectrometry apparatus includes a sample table holding a sample which is a mass spectrometry target, and comprising a temperature control mechanism for the sample, an ion beam irradiation device which irradiates an ion beam on the sample to generate neutral particles, a laser irradiation device which irradiates the neutral particles with a laser to obtain photoexcited ions, a mass spectrometer which draws in the drawn out photoexcited ions and performs mass analysis, a driving system mirror which is provided retractably on a laser light path between the laser irradiation device and the sample table, and reflects the laser when positioned within the laser light path, and, a profiler which is arranged in a reflective direction of the driving system mirror and detects a feature of the laser.

Abstract translation: 溅射中性粒子质谱装置包括：样品台，其保持作为质谱分析对象的样品，并且包括用于样品的温度控制机构;将离子束照射在样品上以产生中性粒子的离子束照射装置; 用激光照射中性粒子以获得光激发离子的激光照射装置，吸取被引出的光激发离子并进行质量分析的质谱仪，在激光照射装置之间的激光路径上可缩回地设置的驱动系统反射镜 和样品台，并且当位于激光光路内时反射激光器，以及沿驱动系统反射镜的反射方向布置并检测激光器的特征的轮廓仪。

公开(公告)号：US20150270111A1

公开(公告)日：2015-09-24

申请号：US14664375

申请日：2015-03-20

Applicant: Lockheed Martin Corporation

Inventor： John Arthur WOOD

IPC: H01J49/10 ,  H01J49/42 ,  H01J49/16

CPC classification number: H01J49/107 ,  H01J49/145 ,  H01J49/161 ,  H01J49/168 ,  H01J49/24 ,  H01J49/42

Abstract: Systems and methods for a mass spectrometer include an atmospheric-pressure chemical ionization (APCI) source, one or more low-pressure chemical ionization (LPCI) sources, a mass analyzer configured to separate ions of a sample flow from the APCI source and the one or more LPCI sources, a detector configured to identify and quantify the received separated ions, and a plurality of valves configured to open and close associated input lines to the APCI source and the one or more LPCI sources, via a computer-implemented controller, and configured to maintain a vacuum environment of the mass spectrometer during the opening and closing.

Abstract translation: 用于质谱仪的系统和方法包括大气压化学电离（APCI）源，一个或多个低压化学电离源（LPCI）源，质量分析器，被配置为将样品流的离子与APCI源分离， 或更多个LPCI源，被配置为识别和量化所接收的分离的离子的检测器，以及配置成经由计算机实现的控制器来打开和关闭到APCI源和一个或多个LPCI源的相关输入线的多个阀，以及 被配置为在打开和关闭期间维持质谱仪的真空环境。

公开(公告)号：US20140340093A1

公开(公告)日：2014-11-20

申请号：US14279825

申请日：2014-05-16

Applicant: Brechtel Manufacturing, Inc.

Inventor： Frederick J. BRECHTEL

IPC: G01R29/24

CPC classification number: G01N27/66 ,  G01N27/624 ,  G01R29/24 ,  H01J27/02 ,  H01J49/145 ,  H01J49/161

Abstract: A system and method comprising a liquid interface with an electrode. The electrode may be coupled to a MEMS-based electrometer for sensing small amounts of charge imposed on the electrode. In some embodiments ion exchangers may be employed to provide for specific selectivity for certain ions or molecules. The electrometer may include a comb drive actuator coupled to a moving shuttle supported on flexures.

Abstract translation: 一种包括与电极的液体界面的系统和方法。 电极可以耦合到基于MEMS的静电计，用于感测施加在电极上的少量电荷。 在一些实施方案中，可以使用离子交换剂来提供某些离子或分子的特定选择性。 静电计可以包括耦合到支撑在挠曲件上的移动梭的梳子驱动致动器。

公开(公告)号：US08030090B2

公开(公告)日：2011-10-04

申请号：US11596769

申请日：2005-05-17

Applicant: Kenzo Hiraoka ,  Satoko Akashi ,  Atsushi Takamizawa ,  Jan Arne Sunner

Inventor： Kenzo Hiraoka ,  Satoko Akashi ,  Atsushi Takamizawa ,  Jan Arne Sunner

IPC: G01N24/00

CPC classification number: H01J49/165 ,  G01N1/44 ,  H01J49/0059 ,  H01J49/161 ,  Y10T436/24

Abstract: A biological sample solution is ionized by electrospray and the sample solution is irradiated with an infrared laser beam to dissociate biological macromolecules into the constituents thereof. As a result, only non-covalent bonds of the biological macromolecules can be selectively severed and analyzed.

Abstract translation: 通过电喷雾离子化生物样品溶液，并用红外激光束照射样品溶液以将生物大分子解离成其组分。 结果，只能选择性地切断和分析生物大分子的非共价键。

公开(公告)号：US07902499B2

公开(公告)日：2011-03-08

申请号：US12259871

申请日：2008-10-28

Applicant: Kenzo Hiraoka ,  Atsushi Takamizawa

Inventor： Kenzo Hiraoka ,  Atsushi Takamizawa

IPC: B01D59/44

CPC classification number: G01N27/62 ,  G01N30/7266 ,  G01N2001/028 ,  G01Q30/02 ,  G01Q60/16 ,  H01J49/0004 ,  H01J49/161 ,  H01J49/165

Abstract: A biological sample can be subjected to measurement, description and ionization of ions is possible under atmospheric pressure without undergoing pretreatment. Imaging having a resolution on the nanometer order can be performed. An STM needle (probe) of an XYZ-axis-drive piezoelectric element is oscillated along the Z axis to contact the sample to a depth on the nanometer order and capture molecules at the needle tip. A pulsed high voltage is applied to the needle, achieving needle electrospray. The sample molecules are then desorbed and ionized, and mass spectrometry is carried out. The needle is swept in the XY directions, oscillation is repeated and an image obtained by molecular imaging of a nanometer area of the biological sample is measured. The probe may be brought into contact with a droplet produced at the tip of a capillary connected to the outlet port of a liquid chromatograph to capture a sample.

Abstract translation: 可以对生物样品进行测量，在大气压下不需要进行预处理，离子的描述和离子化是可能的。 可以执行具有纳米级分辨率的成像。 XYZ轴驱动压电元件的STM针（探针）沿Z轴振荡，使样品与纳米级的深度接触并捕获针尖处的分子。 向针施加脉冲高压，实现针电喷雾。 然后将样品分子解吸并离子化，并进行质谱。 针在XY方向扫掠，重复振荡，并测量通过生物样品的纳米面积的分子成像获得的图像。 探针可以与在液相色谱仪的出口连接的毛细管尖端处产生的液滴接触以捕获样品。

公开(公告)号：US20060263899A1

公开(公告)日：2006-11-23

申请号：US10546799

申请日：2004-02-24

Applicant: George Agnes

Inventor： George Agnes

IPC: G01N1/10 ,  G01N24/00

CPC classification number: H01J49/164 ,  G01N35/1011 ,  G01N35/1074 ,  G01N2035/1034 ,  H01J49/0009 ,  H01J49/161 ,  Y10T436/24 ,  Y10T436/25

Abstract: This application relates to a process for controllably placing two or more microspots on a target substrate in close proximity to one another. The microspots may then be simultaneously irradiated and the resulting ions detected by mass spectrometry, such as time of flight mass spectrometry. In one embodiment the size and spacing of the microspots on the substrate may be controlled by using an electrodynamic balance during the deposition step. The deposition procedure ensures that at least some of the microspots are spaced-apart on the substrate a distance less than the focused output of a single laser. Simultaneous irradiation of the adjacent microspots may cause desorption plumes of the microspots to interact in a gas phase, such as by ion-molecule reactions. The microspots may be configured to improve the ionization yield of the sample material in the gas phase and/or to increase the frequency of ion-molecule collisions in the gas phase. This allows for desorption of particular classes of compounds to be optimized independently of ionization. Different microspots could include different amounts or types of matrix compounds to enable simultaneously detection of compounds of varied physical and chemical properties within the same sample. One or more of the microspots may include calibrants or other additives for improving detecting accuracy or quantitation. Organized array of closely packed microspots may be created for use as standard reference materials or analyte detectors.

Abstract translation: 本申请涉及一种用于将两个或更多个微孔子可控地放置在彼此靠近的目标基底上的方法。 然后可以同时照射微孢子，并通过质谱法检测所得到的离子，例如飞行时间质谱。 在一个实施例中，可以通过在沉积步骤期间使用电动平衡来控制衬底上的微孔的尺寸和间隔。 沉积程序确保至少一些微孔在衬底上间隔开距离小于单个激光器的聚焦输出。 相邻微孢子的同时照射可导致微孢子的解吸羽流在气相中相互作用，例如通过离子 - 分子反应。 微滴可以被配置为改善气相中样品材料的离子化收率和/或增加气相中离子 - 分子碰撞的频率。 这允许特定类别的化合物的解吸，以独立于电离而被优化。 不同的微孔可以包括不同量的或类型的基质化合物，以便同时检测同一样品中不同物理和化学性质的化合物。 一个或多个微点可以包括用于提高检测精度或定量的校准剂或其它添加剂。 可以创建紧密堆积的微孔的组织阵列用作标准参考材料或分析物检测器。