公开(公告)号：US20030198595A1

公开(公告)日：2003-10-23

申请号：US10150654

申请日：2002-05-17

Applicant: IMMUNOMEDICS, INC.

Inventor： David M. Goldenberg ,  Hans J. Hansen ,  Shui-On Leung ,  William J. McBride ,  Zhengxing Qu

IPC: A61K051/00 ,  C07K016/46

CPC classification number: A61K51/1048 ,  A61K47/665 ,  A61K47/6879 ,  A61K51/1063 ,  A61K2039/505 ,  B82Y5/00 ,  C07K5/0215 ,  C07K5/1016 ,  C07K5/1019 ,  C07K7/06 ,  C07K16/18 ,  C07K16/3007 ,  C07K16/3046 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/12 ,  C07K2317/13 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2319/00

Abstract: The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.

Abstract translation: 本发明涉及具有特异性结合目标组织的至少一个臂的特异性抗体或抗体片段以及特异性结合可靶向构建体的至少一个其他臂。 可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。 可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。 本发明提供用于产生双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。

公开(公告)号：US20030017154A1

公开(公告)日：2003-01-23

申请号：US10150664

申请日：2002-05-16

Inventor： Jeffrey G. Hunchar ,  Craig W. Henry

IPC: A61K039/395

CPC classification number: C07K16/26 ,  A61K2039/505 ,  C07K2317/11 ,  C07K2317/12

Abstract: The invention is directed to a method and food product for increasing uniformity in avians. The method comprises administering to an avian an effective amount of a composition comprising a gastrointestinal neuro-modulator antibody in order to neutralize the gastrointestinal neuro-modulator.

Abstract translation: 本发明涉及用于增加鸟类的均匀性的方法和食品。 该方法包括向鸟类施用有效量的包含胃肠神经调节剂抗体的组合物以中和胃肠神经调节剂。

公开(公告)号：US20230192813A1

公开(公告)日：2023-06-22

申请号：US17926359

申请日：2021-05-18

Applicant: IGNOVA GMBH

Inventor： Jan WESJOHANN ,  Michael GERRITS ,  Tonchy UGRINOVIC ,  Nguyen VAN SA ,  Andreas MICHELS

IPC: C07K16/02 ,  C07K16/04 ,  C07K16/10 ,  A61P31/14 ,  A61K45/06 ,  A61K39/42

CPC classification number: C07K16/02 ,  C07K16/04 ,  C07K16/10 ,  A61P31/14 ,  A61K45/06 ,  A61K39/42 ,  C07K2317/76 ,  C07K2317/12 ,  C07K2317/23

Abstract: The present invention relates to an antibody that binds specifically to the SARS CoV-2 spike protein, and methods for its manufacture.

公开(公告)号：US20190209681A1

公开(公告)日：2019-07-11

申请号：US16179696

申请日：2018-11-02

Applicant: Immuron Limited

Inventor： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya`acov

IPC: A61K39/395 ,  C07K16/12 ,  C07K16/04 ,  C07K16/26

CPC classification number: A61K39/39508 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/04 ,  C07K16/1232 ,  C07K16/26 ,  C07K2317/12

Abstract: The invention relates to the use of preparations enriched with anti LPS antibodies, such as those derived from mammalian colostrum or avian eggs, and optionally further antibodies against disease-associated antigens, colostrums, milk or milk product component/s and any adjuvants for treating, delaying or preventing the progression of a pathologic disorder such as chronic liver disease, cirrhosis and any complication or disorder associated therewith. The invention further relates to combined compositions comprising a combination of anti-LPS enriched antibody preparations and antibodies recognizing at least one antigen specific for a pathologic disorder and uses thereof in the treatment of immune-related disorders.

公开(公告)号：US20180221474A1

公开(公告)日：2018-08-09

申请号：US15325654

申请日：2015-07-10

Applicant: IOGENETICS, LLC

Inventor： Robert D. Bremel ,  Jane Homan

IPC: A61K39/395 ,  C07K16/04 ,  A61K9/00

CPC classification number: A61K39/39508 ,  A61K9/0053 ,  A61K39/39583 ,  A61K39/39591 ,  C07K16/00 ,  C07K16/04 ,  C07K2317/12 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/94

Abstract: The present invention provides a means to prepare a product from domestic animal milk, blood or eggs which comprises an array of T-cell exposed motifs similar in identity, distribution and concentration to those found in human immunoglobulin variable regions and to prepare and apply the product as an immune modulating agent for administration either as a nutritional supplement or as a pharmaceutical product.

公开(公告)号：US20180079779A1

公开(公告)日：2018-03-22

申请号：US15562134

申请日：2016-04-01

Applicant: Laboratoire Francais du Fractionnement et des Biotechnologies

Inventor： Sandrine DE MARCO

IPC: C07K1/36 ,  C07K1/14 ,  C07K1/16 ,  C07K16/04 ,  C07K1/34 ,  C07K16/24

CPC classification number: C07K1/36 ,  C07K1/14 ,  C07K1/165 ,  C07K1/30 ,  C07K1/34 ,  C07K16/04 ,  C07K16/241 ,  C07K2317/12 ,  C07K2317/24

Abstract: The invention relates to a method for the purification of a therapeutic protein from transgenic milk, comprising a clarification step using a salt of poly(diallyldimethylammonium).

公开(公告)号：US20170342149A1

公开(公告)日：2017-11-30

申请号：US15139657

申请日：2016-04-27

Applicant: Circle 33 LLC

Inventor： Barbara S. Fox

IPC: C07K16/28 ,  C07K16/04 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/04 ,  C07K16/2896 ,  C07K2317/12 ,  C07K2317/34 ,  C07K2317/76

Abstract: The present invention provides pharmaceutical compositions formulated for direct delivery to the GI tract of a patient comprising an antibody specific for a target apical intestinal receptor. The present invention further provides methods of treating diseases and conditions in a patient comprising administering directly to the GI tract of the patient, compositions of the present invention wherein modulation of the target apical intestinal receptor by the antibody treats the condition.

公开(公告)号：US20160251414A1

公开(公告)日：2016-09-01

申请号：US15033485

申请日：2014-10-29

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LIMITED

Inventor： Yaron Ilan ,  Meir Mizrahi

IPC: C07K16/12 ,  G01N33/52

CPC classification number: C07K16/1203 ,  A61K35/20 ,  A61K2039/505 ,  C07K2317/12 ,  C07K2317/20 ,  C07K2317/76 ,  G01N33/52 ,  G01N33/6893 ,  G01N2800/085 ,  G01N2800/7052

Abstract: This invention relates to methods and compositions for treating fibrosis, by administering compositions comprising anti-LPS immunoglobulin enriched colostrum preparations. In particular, the invention relates to methods and compositions for the treatment of liver fibrosis and/or lung fibrosis. Prophylactic or therapeutic compositions and diagnostic methods are also disclosed and claimed.

Abstract translation: 本发明涉及通过施用含有抗LPS免疫球蛋白的初乳制剂的组合物来治疗纤维化的方法和组合物。 特别地，本发明涉及用于治疗肝纤维化和/或肺纤维化的方法和组合物。 还公开并要求保护的预防或治疗组合物和诊断方法。

公开(公告)号：US20140147446A1

公开(公告)日：2014-05-29

申请号：US14061301

申请日：2013-10-23

Applicant: AVAXIA BIOLOGICS, INCORPORATED

Inventor： Barbara S. Fox

IPC: C07K16/28

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/04 ,  C07K16/2896 ,  C07K2317/12 ,  C07K2317/34 ,  C07K2317/76

Abstract: The present invention provides pharmaceutical compositions formulated for direct delivery to the GI tract of a patient comprising an antibody specific for a target apical intestinal receptor. The present invention further provides methods of treating diseases and conditions in a patient comprising administering directly to the GI tract of the patient, compositions of the present invention wherein modulation of the target apical intestinal receptor by the antibody treats the condition.

Abstract translation: 本发明提供了配制用于直接递送至包含靶向顶端肠道受体特异性抗体的患者胃肠道的药物组合物。 本发明还提供了治疗患者疾病和病症的方法，包括直接给予患者胃肠道的方法，其中本发明的组合物，其中由抗体调节靶顶端肠道受体处理该病症。

公开(公告)号：US20140046033A1

公开(公告)日：2014-02-13

申请号：US14057243

申请日：2013-10-18

Applicant: Daniel Schindler ,  Harry M. Meade ,  Timothy Edmunds ,  John McPherson

Inventor： Daniel Schindler ,  Harry M. Meade ,  Timothy Edmunds ,  John McPherson

IPC: C07K16/28

CPC classification number: C07K16/283 ,  A61K2039/505 ,  C07K16/04 ,  C07K16/2875 ,  C07K16/2878 ,  C07K2317/12 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734

Abstract: The invention relates, in part, to antibodies with increased ADCC activity. Methods of producing such antibodies are also provided. The antibodies of the invention are produced in mammary epithelial cells, such as those in a non-human transgenic animal engineered to express and secrete the antibody in its milk. The antibodies or compositions comprising the antibodies can be used to treat disease in which ADCC activity provides a benefit. In one embodiment, therefore, the antibodies or compositions comprising the antibodies can be used to treat cancer, lymphoproliferative disease or autoimmune disease.

Abstract translation: 本发明部分地涉及具有增加的ADCC活性的抗体。 还提供了产生此类抗体的方法。 本发明的抗体在乳腺上皮细胞中产生，例如在工程化以在其牛奶中表达和分泌抗体的非人转基因动物中的抗体。 包含抗体的抗体或组合物可用于治疗其中ADCC活性提供益处的疾病。 因此，在一个实施方案中，包含抗体的抗体或组合物可用于治疗癌症，淋巴组织增生性疾病或自身免疫性疾病。