公开(公告)号：US20190209681A1

公开(公告)日：2019-07-11

申请号：US16179696

申请日：2018-11-02

申请人： Immuron Limited

发明人： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya`acov

IPC分类号： A61K39/395 ,  C07K16/12 ,  C07K16/04 ,  C07K16/26

CPC分类号： A61K39/39508 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/04 ,  C07K16/1232 ,  C07K16/26 ,  C07K2317/12

摘要： The invention relates to the use of preparations enriched with anti LPS antibodies, such as those derived from mammalian colostrum or avian eggs, and optionally further antibodies against disease-associated antigens, colostrums, milk or milk product component/s and any adjuvants for treating, delaying or preventing the progression of a pathologic disorder such as chronic liver disease, cirrhosis and any complication or disorder associated therewith. The invention further relates to combined compositions comprising a combination of anti-LPS enriched antibody preparations and antibodies recognizing at least one antigen specific for a pathologic disorder and uses thereof in the treatment of immune-related disorders.

公开(公告)号：US09402902B2

公开(公告)日：2016-08-02

申请号：US14138834

申请日：2013-12-23

申请人： Immuron Limited

发明人： Roy Michael Robins-Browne ,  Grant Thomas Rawlin ,  Gottfried Lichti

IPC分类号： A61K39/40 ,  A61B5/0205 ,  A61B5/00 ,  A61B5/021 ,  A61B5/024 ,  A61B17/00

CPC分类号： A61K39/40 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/4821 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2017/00022 ,  G06F19/00

摘要： The present invention provides a method of treatment or prophylaxis of enteric disease caused by Gram negative bacteria. The method includes the step of administering a vaccine or a hyperimmune material raised against said vaccine to an individual. The vaccine comprises one or more cell wall antigens reactive in a manner characteristic of O group serotypes, or reactive in a manner characteristic of lipopolysaccharide associated antigens, and at least some of said antigens are separated from bacterial cell walls or wall fragments. The invention also provides composition containing hyperimmune material as well as uses of the composition and vaccine.

摘要翻译： 本发明提供了治疗或预防由革兰氏阴性菌引起的肠道疾病的方法。 该方法包括向个体施用针对所述疫苗产生的疫苗或超免疫材料的步骤。 疫苗包含以O组血清型特征的方式反应的一种或多种细胞壁抗原，或以脂多糖相关抗原特征的方式反应，并且至少一些所述抗原与细菌细胞壁或壁碎片分离。 本发明还提供含有超免疫材料的组合物以及组合物和疫苗的用途。

公开(公告)号：US20160083457A1

公开(公告)日：2016-03-24

申请号：US14785527

申请日：2014-04-17

申请人： IMMURON LIMITED

发明人： Dena LYRAS ,  Melanie HUTTON ,  Bliss CUNNINGHAM ,  Lucy LI ,  Glen CARTER ,  Julian ROOD

IPC分类号： C07K16/12 ,  A61K39/40 ,  A61K9/00 ,  C07K16/04

CPC分类号： C07K16/1282 ,  A61K9/0053 ,  A61K39/40 ,  A61K2039/505 ,  A61K2039/522 ,  C07K16/04 ,  C07K2317/12 ,  C07K2317/76

摘要： The present invention relates to methods and compositions for the treatment and/or prophylaxis of Clostridium difficile associated disease (CD AD). In particular, the invention relates to antibodies that bind to C. difficile antigens and are capable of inhibiting C. difficile infection, at least one symptom of C. difficile associated disease, shedding of C. difficile, and C. difficile associated mortality. The compositions of the present application comprise: mammalian or avian antibodies which bind to a C. difficile Toxin B; and mammalian or avian antibodies that bind to a C. difficile vegetative cell antigen and/or a C. difficile endospore antigen.

摘要翻译： 本发明涉及用于治疗和/或预防艰难梭菌相关疾病（CD AD）的方法和组合物。 特别地，本发明涉及结合艰难梭菌抗原并能够抑制艰难梭菌感染，艰难梭菌相关疾病的至少一种症状，艰难梭菌切除和艰难梭菌相关死亡率的抗体。 本申请的组合物包含：与艰难梭菌毒素B结合的哺乳动物或禽类抗体; 以及结合艰难梭菌营养细胞抗原和/或艰难梭菌内孢子抗原的哺乳动物或禽抗体。

公开(公告)号：US10144775B2

公开(公告)日：2018-12-04

申请号：US14785527

申请日：2014-04-17

申请人： IMMURON LIMITED

发明人： Dena Lyras ,  Melanie Hutton ,  Bliss Cunningham ,  Lucy Li ,  Glen Carter ,  Julian Rood

IPC分类号： C07K16/12 ,  A61K9/00 ,  A61K39/00

摘要： The present invention relates to methods and compositions for the treatment and/or prophylaxis of Clostridium difficile associated disease (CD AD). In particular, the invention relates to antibodies that bind to C. difficile antigens and are capable of inhibiting C. difficile infection, at least one symptom of C. difficile associated disease, shedding of C. difficile, and C. difficile associated mortality. The compositions of the present application comprise: mammalian or avian antibodies which bind to a C. difficile Toxin B; and mammalian or avian antibodies that bind to a C. difficile vegetative cell antigen and/or a C. difficile endospore antigen.

公开(公告)号：US20140112938A1

公开(公告)日：2014-04-24

申请号：US14138834

申请日：2013-12-23

申请人： Immuron Limited

发明人： Roy Michael Robins-Browne ,  Grant Thomas Rawlin ,  Gottfried Lichti

IPC分类号： A61K39/40

CPC分类号： A61K39/40 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/4821 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2017/00022 ,  G06F19/00

摘要： The present invention provides a method of treatment or prophylaxis of enteric disease caused by Gram negative bacteria. The method includes the step of administering a vaccine or a hyperimmune material raised against said vaccine to an individual. The vaccine comprises one or more cell wall antigens reactive in a manner characteristic of O group serotypes, or reactive in a manner characteristic of lipopolysaccharide associated antigens, and at least some of said antigens are separated from bacterial cell walls or wall fragments. The invention also provides composition containing hyperimmune material as well as uses of the composition and vaccine.

摘要翻译： 本发明提供了治疗或预防由革兰氏阴性菌引起的肠道疾病的方法。 该方法包括向个体施用针对所述疫苗产生的疫苗或超免疫材料的步骤。 疫苗包含以O组血清型特征的方式反应的一种或多种细胞壁抗原，或以脂多糖相关抗原特征的方式反应，并且至少一些所述抗原与细菌细胞壁或壁碎片分离。 本发明还提供含有超免疫材料的组合物以及组合物和疫苗的用途。

公开(公告)号：US20130164302A1

公开(公告)日：2013-06-27

申请号：US13715371

申请日：2012-12-14

申请人： Immuron Limited

发明人： Yaron Ilan ,  Gad Lalazar ,  Ami Ben Yaakov ,  Tomer Adar

IPC分类号： A61K39/395 ,  A61K39/40

CPC分类号： C07K16/26 ,  A61K39/395 ,  A61K2039/55588 ,  A61K2039/57 ,  A61K2300/00

摘要： The present invention relates to immunomodulatory compositions comprising mammalian colostrum-derived immunoglobulin preparation and optionally further colostrums, milk or milk product component/s and any adjuvants for treating immune-related disorders. More specifically, the invention provides compositions comprising colostrum-derived anti-insulin immunoglobulin preparations for the treatment of Metabolic Syndrome. The invention further provides methods and uses of the immunomodulatory compositions for an active or passive immunization in a disease-antigen specific or non specific manner.

摘要翻译： 本发明涉及免疫调节组合物，其包含哺乳动物初乳衍生的免疫球蛋白制备物和任选的另外的初乳，乳或乳制品成分和用于治疗免疫相关病症的任何佐剂。 更具体地，本发明提供了包含用于治疗代谢综合征的初乳衍生的抗胰岛素免疫球蛋白制剂的组合物。 本发明还提供免疫调节组合物在疾病 - 抗原特异性或非特异性方式中的主动或被动免疫的方法和用途。