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公开(公告)号：US07029677B2
公开(公告)日：2006-04-18
申请号：US10327413
申请日：2002-12-19
Applicant: Douglas Dedera , Jian-Rui Wang , Peter C. R. Emtage
Inventor： Douglas Dedera , Jian-Rui Wang , Peter C. R. Emtage
IPC: A61K39/395
CPC classification number: C07K14/70503 , A61K38/00 , A61K2039/505 , C07K14/70596 , C07K14/715 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/2896 , C07K16/3061 , C07K16/38 , C07K2317/77 , C12N9/16 , C12N9/6432 , C12Y304/21006 , G01N33/57492
Abstract: Certain cells, including types of cancer cells such as lymphomas, are capable of expressing high levels of CD84Hy1. Immunotargeting using CD84Hy1 polypeptides, nucleic acids encoding for CD84Hy1 polypeptides and anti-CD84Hy1 antibodies provides a method of killing or inhibiting that growth of CD84HY1Protein-expressing cancer cells. Methods of immunotherapy and diagnosis of disorders associated with CD84Hy1protein-expressing cells are described.
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公开(公告)号：US20050196390A1
公开(公告)日：2005-09-08
申请号：US10893323
申请日：2004-07-19
Applicant: Keith Langley , Yves DeClerck , Thomas Boone
Inventor： Keith Langley , Yves DeClerck , Thomas Boone
IPC: A61K38/00 , C07K14/81 , C07K16/38 , C12N15/70 , C12N15/81 , C12N15/85 , C07H21/04 , A61K38/54 , C12N9/99 , C12N15/09
CPC classification number: C07K16/38 , A61K38/00 , C07K14/8146 , C07K2319/02 , C12N15/70 , C12N15/81 , C12N15/85 , C12N2800/108 , C12N2830/00 , C12N2830/002 , C12N2830/702 , C12N2840/44
Abstract: A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.
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公开(公告)号：US20050142137A1
公开(公告)日：2005-06-30
申请号：US10984960
申请日：2004-11-08
Applicant: Michael Gallo , Daniel Chui , Haihong Zhong , Gulshan Ara , William LaRochelle
Inventor： Michael Gallo , Daniel Chui , Haihong Zhong , Gulshan Ara , William LaRochelle
IPC: A61K39/395 , C07K16/30 , C07K16/38 , C07K16/40
CPC classification number: C07K16/3069 , A01K2217/075 , A61K2039/505 , C07K16/38 , C07K2317/21 , C07K2317/73
Abstract: In accordance with the present invention, there are provided fully human monoclonal antibodies against secretory leukocyte protease inhibitor (SLPI) and antigen binding fragments thereof. Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules are provided. The invention provides antibodies and antigen-binding fragments thereof specifically bind to SLPI; act to neutralize SLPI activity; and can modulate SLPI effects.
Abstract translation: 根据本发明，提供了完全针对分泌白细胞蛋白酶抑制剂（SLPI）的人单克隆抗体及其抗原结合片段。 提供了编码核酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列。 本发明提供抗体及其抗原结合片段特异性结合SLPI; 行动以中和SLPI活动; 并可以调节SLPI效果。
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公开(公告)号：US06893843B2
公开(公告)日：2005-05-17
申请号：US09833799
申请日：2001-04-13
Applicant: Enno Christophers , Oliver Wiedow , Jens-Michael Schroder , Michael Derek Edge , David Pioli
Inventor： Enno Christophers , Oliver Wiedow , Jens-Michael Schroder , Michael Derek Edge , David Pioli
IPC: A61K38/00 , A61K38/55 , A61P11/00 , A61P17/00 , A61P37/00 , C07K1/20 , C07K14/00 , C07K14/39 , C07K14/435 , C07K14/47 , C07K14/81 , C07K16/00 , C07K16/18 , C07K16/38 , C12N1/19 , C12N1/21 , C12N9/99 , C12N15/09 , C12N15/15 , C12N15/81 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/865 , C07H21/02 , C12N15/74
CPC classification number: C12N15/81 , A61K38/00 , C07K14/39 , C07K14/811 , C07K16/38 , C07K2319/02
Abstract: Polypeptides, in particular the polypeptide of formula I: Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys- Pro-Gly-Ser-Cys-Pro-Ile-Ile-Leu-Ile-Arg-Cys-Ala- Met-Leu-Asn-Pro-Pro-Asn-Arg-Cys-Leu-Lys-Asp-Thr- Asp-Cys-Pro-Gly-Ile-Lys-Lys-Cys-Cys-Glu-Gly-Ser- Cys-Gly-Met-Ala-Cys-Phe-Val-Pro-Gln and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such as E. Coli and yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.
Abstract translation: 多肽，特别是式I的多肽：
Pro-Gly-Ser-Val-Ser-Thr-Lys-Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys- Met-Leu-Asn-Pro-Pro-As-Arg-Cys-Leu- Cys-Pro-Ile-Ile-Leu-Ile-Arg-Cys-Ala- Asp-Cys-Pro-Gly-Ile-Lys-Lys-Cys-Cys-Glu-Gly-Ser-Lys-Asp-Thr- ROW>
Cys-Gly-Met-Ala-Cys-Phe-Val-Pro-Gln 其具有对人白细胞弹性蛋白酶的抑制活性的类似物。 多肽可以通过使用诸如大肠杆菌和酵母的宿主中的质粒表达系统进行表达来获得，式I的多肽也可从牛皮癣斑块获得。 -
公开(公告)号：US06806360B2
公开(公告)日：2004-10-19
申请号：US10377817
申请日：2003-03-04
Applicant: Tze Chein Wun , Kuniko K. Kretzmer , George J. Broze, Jr.
Inventor： Tze Chein Wun , Kuniko K. Kretzmer , George J. Broze, Jr.
IPC: C12N1512
CPC classification number: C07K16/38 , A61K38/00 , A61K2039/505 , C07K14/8114
Abstract: A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined.
Abstract translation: 已经开发并表征了具有人组织因子抑制剂（TFI）碱基序列的cDNA克隆，并且已经确定了TFI的氨基酸序列。
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46.发明授权Use of antagonists of plasminogen activator inhibitor-1 (PAI-1) for the treatment of asthma and chronic obstructive pulmonary disease 失效使用纤溶酶原激活物抑制剂-1（PAI-1）拮抗剂治疗哮喘和慢性阻塞性肺疾病公开(公告)号：US06767540B2
公开(公告)日：2004-07-27
申请号：US09759999
申请日：2001-01-12
Applicant: Chad K. Oh , Seong H. Cho , Sossiena Demissie-Sanders , David W. Thomas , Sunny Tan
Inventor： Chad K. Oh , Seong H. Cho , Sossiena Demissie-Sanders , David W. Thomas , Sunny Tan
IPC: A61K39395
CPC classification number: A61K31/711 , A61K31/00 , A61K31/401 , A61K31/417 , A61K31/585 , A61K38/556 , A61K2039/505 , C07K16/38
Abstract: The invention relates to methods for treatment of asthma and chronic obstructive pulmonary disease (COPD) by administration of antagonists to plasminogen activator inhibitor type-1 (PAI-1). Suitable atagonists include antibodies, peptides, proteins, nucleic acids, small organic molecules and polymers.
Abstract translation: 本发明涉及通过给予纤溶酶原激活物抑制剂1型（PAI-1）拮抗剂治疗哮喘和慢性阻塞性肺病（COPD）的方法。 合适的拮抗剂包括抗体，肽，蛋白质，核酸，小有机分子和聚合物。
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公开(公告)号：US20040105862A1
公开(公告)日：2004-06-03
申请号：US10128520
申请日：2002-04-24
Inventor： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
IPC: A61K039/395 , G01N033/53 , C07K016/40
CPC classification number: C07K16/38 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76
Abstract: Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
Abstract translation: 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。
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公开(公告)号：US20030211587A1
公开(公告)日：2003-11-13
申请号：US10141530
申请日：2002-05-07
Inventor： Kiyoshi Ariizumi , Ponciano D. Cruz
IPC: C07H021/04 , C12N009/99 , A61K038/57 , C12P021/02 , C12N005/06 , C07K016/40
CPC classification number: C07K14/811 , C07K14/8139 , C07K16/38
Abstract: The present invention provides a novel keratinocyte-specific secreted protein identified as keptin that inhibits an inflammatory response and activity of proteinase, as well as methods for treating hyperproliferative inflammatory skin diseases using proteinase inhibitor keptin. The invention provides a therapeutic agent for treating psoriasis and squamous cell carcinomas and other inflammatory skin related diseases.
Abstract translation: 本发明提供一种鉴定为抑制炎症反应和蛋白酶活性的新型角质形成细胞特异性分泌蛋白，以及使用蛋白酶抑制剂治疗过度增生性炎性皮肤病的方法。 本发明提供治疗牛皮癣和鳞状细胞癌及其它炎性皮肤相关疾病的治疗剂。
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公开(公告)号：US20020187535A1
公开(公告)日：2002-12-12
申请号：US09833799
申请日：2001-04-13
Inventor： Enno Christophers , Oliver Wiedow , Jens-Michael Schroder , Michael Derek Edge , David Pioli
IPC: A61K038/17 , C12N009/99 , C12N005/06 , C12P021/02
CPC classification number: C12N15/81 , A61K38/00 , C07K14/39 , C07K14/811 , C07K16/38 , C07K2319/02
Abstract: Polypeptides, in particular the polypeptide of formula I: 1 Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys- Pro-Gly-Ser-Cys-Pro-Ile-Ile-Leu-Ile-Arg-Cys-Ala-Met-Leu- Asn-Pro-Pro-Asn-Arg-Cys-Leu-Lys-Asp-Thr-Asp-Cys-Pro-Gly- Ile-Lys-Lys-Cys-Cys-Glu-Gly-Ser-Cys-Gly-Met-Ala-Cys- Phe-Val-Pro-Gln and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such as E. Coli and yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.
Abstract translation: 多肽，特别是式I的多肽：
1 Pro-Gly-Ser-Cys-Pro-Ile-Ile-Leu-Ile-Arg-Cys-Ala -Met-Leu - Asn-Pro-Pro-Asn-Arg-Cys-Leu-Lys-Asp -Thr-Asp-Cys-Pro-Gly - Ile-Lys-Lys-Cys-Cys-Glu -Gly-Ser-Cys-Gly-Met-Ala-Cys - Phe-Val-Pro-Gln 及其对人白细胞弹性蛋白酶具有抑制活性的类似物。 可以通过使用诸如大肠杆菌和酵母的宿主中的质粒表达系统进行表达来获得多肽，式I的多肽也可从牛皮癣斑块获得 -
Patent Agency Ranking
公开(公告)号：US20020090654A1
公开(公告)日：2002-07-11
申请号：US08803954
申请日：1997-02-21
Inventor： KEITH E. LANGLEY , YVES A. DECLERCK , THOMAS C. BOONE
IPC: C07H017/08 , G01N033/53 , G01N033/567 , C07H021/04 , A61K039/395 , C12N005/06 , C12N005/16
CPC classification number: C07K16/38 , A61K38/00 , C07K14/8146 , C07K2319/02 , C12N15/70 , C12N15/81 , C12N15/85 , C12N2800/108 , C12N2830/00 , C12N2830/002 , C12N2830/702 , C12N2840/44
Abstract: A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.
Abstract translation: 公开了一种新型金属蛋白酶抑制剂，其类似物，其编码的多核苷酸及其制备方法。 还公开了治疗由过量金属蛋白酶引起的疾病的药物组合物和方法。
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