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427 条记录 (耗时 0.021 秒)

    Sulfide, sulfinyl and sulfone dipeptide amides
    41.
    发明授权
    Sulfide, sulfinyl and sulfone dipeptide amides 失效
    硫化物，亚磺酰基和砜二肽酰胺

    公开(公告)号：US4757153A

    公开(公告)日：1988-07-12

    申请号：US882796

    申请日：1986-07-14

    申请人： Donald W. Hansen, Jr. ,  Daniel R. Pilipauskas ,  Michael Clare

    发明人： Donald W. Hansen, Jr. ,  Daniel R. Pilipauskas ,  Michael Clare

    IPC分类号： A61K38/00 ,  C07D333/20 ,  C07D333/38 ,  C07D333/48 ,  C07D335/02 ,  C07K5/065 ,  C07D337/00 ,  C07C103/00 ,  C07D331/04 ,  C07D333/36 ,  C07K7/12

    CPC分类号： C07D333/48 ,  C07D333/20 ,  C07D333/38 ,  C07D335/02 ,  C07K5/06078 ,  A61K38/00

    摘要： The invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is hydrogen, lower alkyl, hydroxy, lower alkoxy, --O(CH.sub.2).sub.n phenyl with the phenyl optionally substituted by halogen, --NO.sub.2, --CN, --NH.sub.2 or lower alkyl wherein n is 1 to 4; R.sup.2 and R.sup.3 represent lower alkyl, halogen, or lower alkoxy, or either one of R.sup.2 or R.sup.3 is hydrogen and the other is lower alkyl, lower alkoxy or halogen; R.sup.4, R.sup.5, R.sup.6, and R.sup.9 may be the same or different and represent hydrogen, lower alkyl, cycloalkyl having 3 to 8 carbons, unsaturated lower alkyl, or --(CH.sub.2).sub.m cycloalkyl with the cycloalkyl having 3 to 8 carbons and m is 1 to 4; R.sup.10 is hydrogen or --(CH.sub.2).sub.p phenyl or with the phenyl optionally substituted with --NH.sub.2, --OH, halogen, --NO.sub.2, or lower alkyl or --(CH.sub.2).sub.p thienyl wherein p is 1 to 4; one of R.sup.7 or R.sup.8 is --(CH.sub.2).sub.f --S(O).sub.z --(CH.sub.2).sub.q --CH.sub.3 where f is 1 to 3 and q is 0 to 3, z is 0, 1 or 2 and the other is hydrogen or lower alkyl, or R.sup.7 and R.sup.8 together with carbon w is ##STR2## where x and y are independently 1 to 3 and z is 0, or 2. V represents an asymmetric carbon that may be recemic or have the D or L configuration; W represents an asymmetric carbon when R.sup.7 and R.sup.8 are not the same that may be recemic or have the D or L configuration.The compounds of this invention are useful as analgesic and/or antihypertensive agents.

    摘要翻译： 本发明涉及下式的新型取代的酪氨酸丙氨酸二肽酰胺及其药学上可接受的酸加成盐，其中R1是氢，低级烷基，羟基，低级烷氧基，-O（CH2）n-苯基，其中苯基任选被 卤素，-NO 2，-CN，-NH 2或低级烷基，其中n为1至4; R2和R3表示低级烷基，卤素或低级烷氧基，或R2或R3中的任一个为氢，另一个为低级烷基，低级烷氧基或卤素; R 4，R 5，R 6和R 9可以相同或不同，表示氢，低级烷基，具有3-8个碳原子的环烷基，不饱和低级烷基或 - （CH 2）m环烷基，环烷基具有3至8个碳原子，m是1 到4; R 10是氢或 - （CH 2）p苯基或与-NH 2，-OH，卤素，-NO 2或低级烷基或 - （CH 2）p噻吩基取代的苯基，其中p为1至4; R 7或R 8中的一个为 - （CH 2）f S（O）z - （CH 2）q -CH 3，其中f为1至3，q为0至3，z为0,1或2，而另一个为氢或低级烷基 或者R 7和R 8与碳w一起为，其中x和y独立地为1〜3，z为0或2.V表示可以是接受或具有D或L构型的不对称碳; 当R7和R8不相同时，W表示不对称碳，其可以是可接受的或具有D或L构型。 本发明的化合物可用作镇痛药和/或抗高血压药。

    .beta.-eliminating polymers for diffusion control in photographic products
    46.
    发明授权
    .beta.-eliminating polymers for diffusion control in photographic products 失效
    β-消光聚合物用于照相产品中的扩散控制

    公开(公告)号：US4522996A

    公开(公告)日：1985-06-11

    申请号：US624826

    申请日：1984-06-26

    申请人： Lloyd D. Taylor

    发明人： Lloyd D. Taylor

    IPC分类号： C07D333/48 ,  G03C8/54 ,  C08F228/06 ,  C08F226/02

    CPC分类号： C07D333/48 ,  G03C8/54

    摘要： Polymerizable monomeric carbamates are disclosed. Polymers comprising recurring units from such carbamates undergo .beta.-elimination in an alkaline environment and are useful in diffusion control layers in diffusion transfer photographic products.

    摘要翻译： 公开了可聚合的单体氨基甲酸酯。 包含来自这种氨基甲酸酯的重复单元的聚合物在碱性环境中经历β-邻苯二酚化，并且可用于扩散转印照相产品中的扩散控制层。

    Pesticidal phosphoryl- and phosphinyl-thioalkyl cyclic sufones
    48.
    发明授权
    Pesticidal phosphoryl- and phosphinyl-thioalkyl cyclic sufones 失效
    杀虫磷酰基和氧膦基 - 硫代烷基环状磺酸酯

    公开(公告)号：US4461764A

    公开(公告)日：1984-07-24

    申请号：US421178

    申请日：1982-09-22

    申请人： Philip S. Magee

    发明人： Philip S. Magee

    IPC分类号： A01N57/08 ,  C07D333/48 ,  C07F9/24 ,  C07F9/40 ,  C07F9/42 ,  C07F9/6553 ,  A01N57/32

    CPC分类号： C07D333/48 ,  A01N57/08 ,  C07F9/2408 ,  C07F9/4075 ,  C07F9/425 ,  C07F9/655345

    摘要： Compounds of the formula: ##STR1## wherein X is sulfur or oxygen; R.sub.1 is lower alkyl; R.sub.2 is lower alkyl, lower straight chain alkoxy, lower alkylthio, phenyl or the group --NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl, provided that when X is oxygen, R.sub.2 is not phenyl, are pesticidal, exhibiting activity against pests such as plant fungal diseases and, in many cases, insects.

    摘要翻译： 下式的化合物：其中X是硫或氧; R1是低级烷基; R2是低级烷基，低级直链烷氧基，低级烷硫基，苯基或-NR3R4基团，其中R3和R4独立地是氢或低级烷基，条件是当X是氧时，R 2不是苯基，是杀虫剂，表现出对害虫的活性， 作为植物真菌病，在许多情况下是昆虫。

    N-(Benzenesulfonyl) carbamates herbicidal antidotes
    49.
    发明授权
    N-(Benzenesulfonyl) carbamates herbicidal antidotes 失效
    N-（苯磺酰基）氨基甲酸酯除草剂

    公开(公告)号：US4434000A

    公开(公告)日：1984-02-28

    申请号：US069486

    申请日：1979-08-24

    申请人： Martin D. Mahoney ,  Edmund J. Gaughan ,  Ferenc M. Pallos ,  Hsiao-Ling Lam

    发明人： Martin D. Mahoney ,  Edmund J. Gaughan ,  Ferenc M. Pallos ,  Hsiao-Ling Lam

    IPC分类号： A01N25/32 ,  C07D319/06 ,  C07D333/48 ,  A01N43/00 ,  A01N37/18 ,  A01N47/30

    CPC分类号： C07D333/48 ,  A01N25/32 ,  C07D319/06

    摘要： Compositions comprise an urea herbicide and a N-(benzenesulfonyl) carbamate of the formula ##STR1## in which X and Y are independently selected from the group consisting of hydrogen and methyl;Z is selected from the group consisting of hydrogen, methyl, chloro, and trifluoromethyl; andR' is selected from the group consisting of 1-4 carbon alkyl, 1-4 carbon haloalkyl, 3-6 carbon alkenyl, 3-6 carbon haloalkenyl, 3-6 carbon alkynyl, cyanoethylthioethyl, 2-6 carbon alkoxyalkyl, diethylhydroxylamine, acetoxime, methylthioacetimidate, substituted phenyl, substituted benzyl, and sulfolane.

    摘要翻译： 组合物包含尿素除草剂和式“IMAGE”的N-（苯磺酰基）氨基甲酸酯，其中X和Y独立地选自氢和甲基; Z选自氢，甲基，氯和三氟甲基; 并且R'选自1-4个碳烷基，1-4个碳卤代烷基，3-6个碳烯基，3-6个碳卤代烯基，3-6个碳炔基，氰基乙硫基乙基，2-6个碳烷氧基烷基，二乙基羟胺， 乙酰肟，甲硫基亚乙酰亚胺酯，取代的苯基，取代的苄基和环丁砜。

    Preparation of novel perfluorinated sulphonic acid fluorides
    50.
    发明授权
    Preparation of novel perfluorinated sulphonic acid fluorides 失效
    新型全氟磺酸氟化物的制备

    公开(公告)号：US4411841A

    公开(公告)日：1983-10-25

    申请号：US315766

    申请日：1981-10-28

    申请人： Klaus Geisler

    发明人： Klaus Geisler

    IPC分类号： B01F17/00 ,  B05D5/00 ,  C07C67/00 ,  C07C301/00 ,  C07C309/80 ,  C07C309/82 ,  C07D333/48 ,  C25B3/08 ,  D06M13/256 ,  C07C143/70

    CPC分类号： C07D333/48 ,  C07C309/00 ,  C25B3/08

    摘要： Electrochemical fluorination of a thiophene-1,1-dioxide derivative of the formula ##STR1## produces the novel perfluorinated sulphonic acid fluoride of the formula ##STR2## in which X, Y and Z each independently is F, a perfluoroalkyl group having 1 to 8 C-atoms in which one or more CF.sub.2 groups may optionally be replaced by oxygen, the oxygen atoms being separated by at least one CF.sub.2 group, optionally perfluoroalkyl-substituted cycloperfluoroalkyl group having 5 to 12 C-atoms in which one or more CF.sub.2 groups may be replaced by oxygen, orX and Y together denote an optionally perfluoroalkyl-substituted cycloperfluoroalkyl group in which one or more CF.sub.2 groups may be replaced by oxygen,R.sub.f each independently is F or a perfluoroalkyl group having 1 to 3 C-atoms, andn and m each independently is 0 or 1.The products are useful as surface active agents.

    摘要翻译： 式“IMAGE”的噻吩-1,1-二氧化物衍生物的电化学氟化产生式“IMAGE”的新型全氟化磺酰氟，其中X，Y和Z各自独立地为F，具有1至8个的全氟烷基 其中一个或多个CF 2基团可以任选地被氧代替的C原子，氧原子被至少一个CF 2基团分离，任选地具有5至12个C原子的全氟烷基取代的全氟代烷基，其中一个或多个CF 2基团可以 由氧代替，或X和Y一起表示任选的全氟烷基取代的环氟烷基，其中一个或多个CF 2基团可被氧代替，Rf各自独立地为F或具有1至3个C原子的全氟烷基，n m各自独立地为0或1.该产物可用作表面活性剂。