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51 条记录 (耗时 0.057 秒)

    Agonists of Guanylate Cyclase Useful For the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
    43.
    发明申请
    Agonists of Guanylate Cyclase Useful For the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders 有权
    鸟苷酸环化酶的激动剂有助于治疗胃肠道疾病，炎症，癌症和其他疾病

    公开(公告)号：US20130096071A1

    公开(公告)日：2013-04-18

    申请号：US13716874

    申请日：2012-12-17

    申请人： SYNERGY PHARMACEUTICALS INC.

    发明人： Kunwar Shailubhai ,  Gary S. Jacob

    IPC分类号： C07K7/64

    CPC分类号： C07K7/64 ,  A61K38/04 ,  A61K45/06 ,  C07K7/08 ,  A61K2300/00

    摘要： The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer.

    摘要翻译： 本发明提供新的鸟苷酸环化酶-C激动剂肽及其在治疗包括胃肠道疾病，炎症或癌症（例如胃肠癌））的人类疾病中的用途。 肽可以单独施用或与cGMP依赖性磷酸二酯酶抑制剂组合施用。 胃肠道疾病可以分为肠易激综合征，便秘或过度酸度等。胃肠道疾病可分为炎症性肠病或其他胃肠道疾病，包括克罗恩病和溃疡性结肠炎，以及癌症。

    Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
    45.
    发明授权
    Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders 有权
    鸟苷酸环化酶的激动剂可用于治疗胃肠道疾病，炎症，癌症和其他疾病

    公开(公告)号：US07879802B2

    公开(公告)日：2011-02-01

    申请号：US12133344

    申请日：2008-06-04

    申请人： Kunwar Shailubhai ,  Gary S. Jacob

    发明人： Kunwar Shailubhai ,  Gary S. Jacob

    IPC分类号： A61K38/00

    CPC分类号： C07K7/08 ,  A61K9/0031 ,  A61K9/02 ,  A61K9/08 ,  A61K31/192 ,  A61K31/519 ,  A61K38/10 ,  A61K38/12 ,  A61K45/06 ,  A61K47/02 ,  A61K47/60 ,  C07K7/64

    摘要： The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition, including Crohn's disease and ulcerative colitis, and cancer.

    摘要翻译： 本发明提供新的鸟苷酸环化酶-C激动剂肽及其在治疗包括胃肠道疾病，炎症或癌症（例如胃肠癌））的人类疾病中的用途。 肽可以单独施用或与cGMP依赖性磷酸二酯酶抑制剂组合施用。 胃肠道疾病可以分为肠易激综合征，便秘或过度酸度等。胃肠道疾病可分为炎症性肠病或其他GI病症，包括克罗恩病和溃疡性结肠炎，以及癌症。

    Method of inhibiting bile acid absorption by administering an agonist of a guanylate cyclase receptor
    49.
    发明授权
    Method of inhibiting bile acid absorption by administering an agonist of a guanylate cyclase receptor 有权
    通过施用鸟苷酸环化酶受体的激动剂来抑制胆汁酸吸收的方法

    公开(公告)号：US09089612B2

    公开(公告)日：2015-07-28

    申请号：US13513224

    申请日：2010-12-03

    申请人： Kunwar Shailubhai

    发明人： Kunwar Shailubhai

    IPC分类号： A61K38/10 ,  C07K7/08 ,  A61K47/48 ,  A61P1/04

    CPC分类号： A61K38/10 ,  A61K45/06 ,  A61K47/60 ,  A61P35/00 ,  C07K7/08

    摘要： This invention also provides a method to prevent, control, and treat a lipid metabolism disorder, a biliary disorder, cardiovascular disease, obesity or an endocrine disorder by administering at least one agonist of guanalyte cyclase receptor either alone or in combination with a compound typically used to treat the disorder and or with an inhibitor of cGMP-dependent phosphodieasterases.

    摘要翻译： 本发明还提供了通过单独给予至少一种鸟苷酸环化酶受体激动剂或与通常使用的化合物组合来预防，控制和治疗脂质代谢紊乱，胆汁疾病，心血管疾病，肥胖症或内分泌疾病的方法 治疗该疾病和/或使用cGMP依赖性磷酸二酯酶抑制剂。