公开(公告)号：US07871608B2

公开(公告)日：2011-01-18

申请号：US12197617

申请日：2008-08-25

Applicant: Thomas P. Zimmerman ,  Valery Novokhatny ,  Shan Jiang ,  James Colandene

Inventor： Thomas P. Zimmerman ,  Valery Novokhatny ,  Shan Jiang ,  James Colandene

IPC: C12N9/48 ,  C12N9/72 ,  C13N9/68

CPC classification number: C12N9/6435 ,  A61K38/4833 ,  A61K38/484 ,  A61K45/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  C12N9/96 ,  C12N9/99 ,  C12Y304/21007

Abstract: A method of treating a subject, the method including administring a composition that includes a reversibly inactivated acidfied plasmin substantially free of a plasminogen activator, in a low buffering capacity buffer, wherein the composition is a solution suitable for pharmacenutical use that can be raised to physiological pH by adding no more than about 5 volumes of serum to the solution relative to a volume of the solution.

Abstract translation: 一种治疗受试者的方法，所述方法包括在低缓冲容量缓冲液中施用包含基本上不含纤溶酶原激活物的可逆失活的酸性纤溶酶的组合物，其中所述组合物是适于药物使用的溶液，其可以升高至生理 通过相对于一定体积的溶液向该溶液中加入不超过约5体积的血清的pH。

公开(公告)号：US07488815B2

公开(公告)日：2009-02-10

申请号：US11084085

申请日：2005-03-17

Applicant: Andrew P. Feinberg ,  Liora Strichman-Almashanu ,  Shan Jiang

Inventor： Andrew P. Feinberg ,  Liora Strichman-Almashanu ,  Shan Jiang

IPC: C07H21/04

CPC classification number: C12N5/0611 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/235 ,  C12N2501/385 ,  C12N2502/13 ,  C12N2503/00 ,  C12N2503/02 ,  C12N2510/00 ,  C12N2517/00 ,  C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/154

Abstract: Genomic imprinting is a parent of origin-dependent gene silencing that involves marking of alleles in the germline and differential expression in somatic cells of the offspring. Imprinted genes and abnormal imprinting have been implicated in development, human disease, and embryonic stem cell transplantation. We have established a model system for genomic imprinting using pluripotent 8.5 d.p.c. mouse embryonic germ (EG) cell lines derived from an interspecific cross. We find that allele-specific imprinted gene expression has been lost in these cells. However, partial restoration of allele-specific silencing can occur for some imprinted genes after in vitro differentiation of EG cells into somatic cell lineages, indicating the presence of a gametic memory that is separable from allele-specific gene silencing. We have also generated a library containing most methylated CpG islands. A subset of these clones was analyzed and revealed a subdivision of methylated CpG islands into 4 distinct subtypes: CpG islands belonging to high copy number repeat families; unique CpG islands methylated in all tissues; unique methylated CpG islands that are unmethylated in the paternal germline; and unique CpG islands methylated in tumors. This approach identifies a methylome of methylated CpG islands throughout the genome.

Abstract translation: 基因印记是起源依赖基因沉默的亲本，其涉及在种系中标记等位基因和在后代的体细胞中的差异表达。 印迹基因和异常印记涉及发育，人类疾病和胚胎干细胞移植。 我们已经建立了使用多能8.5 d.p.c的基因组印迹模型系统。 来自种间交叉的小鼠胚胎胚芽（EG）细胞系。 我们发现在这些细胞中已经丢失了等位基因特异性印记的基因表达。 然而，在将EG细胞体外分化成体细胞谱系后，一些印迹基因可能发生等位基因特异性沉默的部分恢复，表明存在可与等位基因特异性基因沉默分离的配子记忆。 我们还生成了一个包含大多数甲基化CpG岛的文库。 分析了这些克隆的一个子集，并揭示了甲基化CpG岛分为4个不同的亚型：属于高拷贝数重复家族的CpG岛; 所有组织中独特的CpG岛甲基化; 在父系种系中未甲基化的独特的甲基化CpG岛; 和独特的CpG岛在肿瘤中甲基化。 该方法鉴定了整个基因组中甲基化CpG岛的甲基化。

公开(公告)号：US07357694B2

公开(公告)日：2008-04-15

申请号：US11405753

申请日：2006-04-17

Applicant: Ross Popescu ,  Clarence Tamargo ,  Shan Jiang

Inventor： Ross Popescu ,  Clarence Tamargo ,  Shan Jiang

IPC: H01L21/304

CPC classification number: B24C3/322 ,  B24C1/045 ,  B24C3/02 ,  B24C7/0007 ,  B24C9/006 ,  H01L21/67092 ,  H05K3/0052 ,  Y02P70/179 ,  Y10T117/10

Abstract: Techniques for singulating a substrate into a plurality of component parts is disclosed. The singulation techniques include generating a jet stream in order to cut through large components so as to produce smaller components. The techniques are particularly suitable for singulating surface mount devices such as chip scale packages, ball grid arrays (BGA), flip chips, lead less packages (QFN) and the like. The techniques are also suitable for singulating photonic devices.

Abstract translation: 公开了将衬底分离成多个部件的技术。 分割技术包括产生喷射流以切割大的部件以便产生更小的部件。 这些技术特别适用于分离表面贴装器件，例如芯片级封装，球栅阵列（BGA），倒装芯片，无铅封装（QFN）等。 该技术也适用于单光子器件。

公开(公告)号：US20060194514A1

公开(公告)日：2006-08-31

申请号：US11405753

申请日：2006-04-17

Applicant: Ross Popescu ,  Clarence Tamargo ,  Shan Jiang

Inventor： Ross Popescu ,  Clarence Tamargo ,  Shan Jiang

IPC: B24B49/00

CPC classification number: B24C3/322 ,  B24C1/045 ,  B24C3/02 ,  B24C7/0007 ,  B24C9/006 ,  H01L21/67092 ,  H05K3/0052 ,  Y02P70/179 ,  Y10T117/10

Abstract: Techniques for singulating a substrate into a plurality of component parts is disclosed. The singulation techniques include generating a jet stream in order to cut through large components so as to produce smaller components. The techniques are particularly suitable for singulating surface mount devices such as chip scale packages, ball grid arrays (BGA), flip chips, lead less packages (QFN) and the like. The techniques are also suitable for singulating photonic devices.

公开(公告)号：US20050217406A1

公开(公告)日：2005-10-06

申请号：US11133368

申请日：2005-05-20

Applicant: Shan Jiang

Inventor： Shan Jiang

IPC: B25J5/00 ,  B25J9/10 ,  B25J9/16 ,  F16H55/18 ,  G05B19/404

CPC classification number: B25J9/1641 ,  Y10T74/19898 ,  Y10T74/20305

Abstract: To allow a robot performing a cyclic movement upon receipt of a driving force transmitted through a driving force transmission system from a driving source along with a backlash to perform the movement compensated for the backlash, during a first period within a cycle of the movement of the robot, a predetermined first movement control value is repeatedly cumulatively added with a correction value so as to be gradually biased to a predetermined second movement control value over the first period, and during a second period within that cycle, a correction value is repeatedly cumulatively subtracted from the second movement control value so as to gradually return to the first movement control value over the second period, thereby generating the movement control value for controlling the movement of the robot, and based on the movement control value thus generated, the movement of the robot is controlled.

Abstract translation: 为了允许机器人在接收到通过驱动力传递系统从驱动源传递的驱动力以及间隙执行循环运动以执行补偿间隙的运动时，在运动的循环的第一周期期间执行循环运动 机器人，预定的第一移动控制值被反复累积地加上校正值，以便在第一周期内逐渐地偏向预定的第二移动控制值，并且在该周期内的第二时段期间，反复地累积地减去校正值 从第二移动控制值开始，在第二期间逐渐返回到第一移动控制值，由此生成用于控制机器人的移动的移动控制值，并且基于由此产生的移动控制值， 机器人受到控制。

公开(公告)号：US09959362B2

公开(公告)日：2018-05-01

申请号：US14446171

申请日：2014-07-29

Applicant: Shan Jiang

Inventor： Shan Jiang

IPC: G06F7/00 ,  G06F17/00 ,  G06F17/30 ,  G06F15/16

CPC classification number: G06F17/30893 ,  G06F17/3051 ,  G06F17/30864

Abstract: Techniques are described for creating a context-aware landing page. A context-aware landing page is capable of dynamically updating its tiles to include content tiles which are related to a received triggering event. The triggering event can be received from a business context source. When the triggering event is received, a weighting table that contains a plurality of content tiles can be retrieved. The method can then select one or more content tiles to include in the context-aware landing page. The selection of the one or more content tiles can depend on the triggering event.

公开(公告)号：US07760008B2

公开(公告)日：2010-07-20

申请号：US12259361

申请日：2008-10-28

Applicant: Jia Peng ,  Kwee Chong Chang ,  Shan Jiang

Inventor： Jia Peng ,  Kwee Chong Chang ,  Shan Jiang

IPC: H01H37/76

CPC classification number: G01R31/318511

Abstract: Digital trimming logic is included in a microelectronic device of a type that produces an output signal in response to an input signal and a threshold signal. Trimming logic values are produced in response to a clock signal that is applied to the device in a trimming mode. The clock signal can be applied to a device pin that is used in normal operation to provide an output signal, thus allowing the pin to serve a dual function. The trimming logic changes the trimming logic value in response to the clock signal until the trimming logic value reaches a trim value at which the threshold signal is substantially equal to the input signal. The trimming logic then stores the trim value in a non-volatile memory and enters a locked mode in which further trimming is prevented and the device is ready for normal operation.

Abstract translation: 数字微调逻辑包括在产生响应于输入信号和阈值信号的输出信号的类型的微电子器件中。 修整逻辑值是响应于以修剪模式应用于器件的时钟信号产生的。 时钟信号可以应用于在正常操作中使用的器件引脚以提供输出信号，从而允许引脚具有双重功能。 修整逻辑响应于时钟信号改变修整逻辑值，直到修整逻辑值达到阈值信号基本上等于输入信号的修整值。 然后，修整逻辑将修整值存储在非易失性存储器中，并进入锁定模式，在该模式中防止进一步修整，并且器件准备好进行正常操作。

公开(公告)号：US20100152275A1

公开(公告)日：2010-06-17

申请号：US12630681

申请日：2009-12-03

Applicant: Michael Ernest Fromm ,  Shan Jiang ,  Jess L. Miner

Inventor： Michael Ernest Fromm ,  Shan Jiang ,  Jess L. Miner

IPC: A61K31/201 ,  A61K31/40 ,  A61P3/00 ,  A61P9/00

CPC classification number: A61K31/202 ,  A61K31/40 ,  A61K45/06 ,  A61K2300/00

Abstract: Food, feed or drug combinations with conjugated linoleic acid are described that cause enhanced fat loss in mammals more efficiently than any of the individual components of the combination. Food, feed, or drugs that activate AMP activated protein kinase, agonists of nuclear receptors that bind RXR in adipocytes, or statin inhibitors were found to be more effective for fat loss when combined with conjugated linoleic acid.

Abstract translation: 描述了与共轭亚油酸的食物，饲料或药物组合，其比哺乳动物的任何单独成分更有效地引起脂肪减少。 发现激活AMP活化蛋白激酶的食物，饲料或药物，与脂肪细胞结合RXR的核受体的激动剂或他汀类抑制剂与共轭亚油酸组合时，对脂肪损失更有效。

公开(公告)号：US20100121855A1

公开(公告)日：2010-05-13

申请号：US12689984

申请日：2010-01-19

Applicant: Apurva F. Dalia ,  Craig Allen Harry ,  Nishant Dani ,  Shan Jiang ,  Brad Dean Thompson ,  Bradley J. Barrows ,  David R. Shutt

Inventor： Apurva F. Dalia ,  Craig Allen Harry ,  Nishant Dani ,  Shan Jiang ,  Brad Dean Thompson ,  Bradley J. Barrows ,  David R. Shutt

IPC: G06F15/173 ,  G06F17/30

CPC classification number: G06F3/0644 ,  G06F3/061 ,  G06F3/067

Abstract: A method, system, and computer-readable medium for accessing and managing an online storage system is disclosed. Access to a storage resource in a multiple server storage system is provided by sending to a lookup partitioning service server a resource identifier that is associated with a storage resource stored in a particular storage partition of a storage server. The LPS returns the looked-up partition that stores the storage resource associated with the resource identifier. Access to the storage resource is then enabled to the looked-up storage partition.

Abstract translation: 公开了一种用于访问和管理在线存储系统的方法，系统和计算机可读介质。 通过向查找分区服务服务器发送与存储在存储服务器的特定存储分区中的存储资源相关联的资源标识符来提供对多服务器存储系统中的存储资源的访问。 LPS返回存储与资源标识符相关联的存储资源的查找分区。 然后，对查找的存储分区启用对存储资源的访问。

公开(公告)号：US20100105155A1

公开(公告)日：2010-04-29

申请号：US12259361

申请日：2008-10-28

Applicant: Jia Peng ,  Kwee Chong Chang ,  Shan Jiang

Inventor： Jia Peng ,  Kwee Chong Chang ,  Shan Jiang

IPC: G01R31/26

CPC classification number: G01R31/318511

Abstract: Digital trimming logic is included in a microelectronic device of a type that produces an output signal in response to an input signal and a threshold signal. Trimming logic values are produced in response to a clock signal that is applied to the device in a trimming mode. The clock signal can be applied to a device pin that is used in normal operation to provide an output signal, thus allowing the pin to serve a dual function. The trimming logic changes the trimming logic value in response to the clock signal until the trimming logic value reaches a trim value at which the threshold signal is substantially equal to the input signal. The trimming logic then stores the trim value in a non-volatile memory and enters a locked mode in which further trimming is prevented and the device is ready for normal operation.

Abstract translation: 数字微调逻辑包括在产生响应于输入信号和阈值信号的输出信号的类型的微电子器件中。 修整逻辑值是响应于以修剪模式应用于器件的时钟信号产生的。 时钟信号可以应用于在正常操作中使用的器件引脚以提供输出信号，从而允许引脚具有双重功能。 修整逻辑响应于时钟信号改变修整逻辑值，直到修整逻辑值达到阈值信号基本上等于输入信号的修整值。 然后，修整逻辑将修整值存储在非易失性存储器中，并进入锁定模式，在该模式中防止进一步修整，并且器件准备好进行正常操作。