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公开(公告)号：US09353177B2
公开(公告)日：2016-05-31
申请号：US14636782
申请日：2015-03-03
Applicant: Genentech, Inc.
Inventor： Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic Fellouse , Sachdev S. Sidhu , Christian Wiesmann
IPC: C07K16/22 , A61K39/395 , C12P21/08
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
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公开(公告)号：US20160102146A1
公开(公告)日：2016-04-14
申请号：US14856731
申请日：2015-09-17
Applicant: GENENTECH, INC.
Inventor： Jo-Anne Hongo , Weiguang Mao , Paul Polakis , Andrew Polson , Rajesh Vij , Yan Wu , Wei-Ching Liang
IPC: C07K16/28
CPC classification number: C07K16/28 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6849 , A61K47/6859 , A61K47/6863 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/24 , C07K2317/33 , C07K2317/73 , C07K2317/92 , G01N33/6893
Abstract: The invention provides anti-LgR5 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20160075787A1
公开(公告)日：2016-03-17
申请号：US14852369
申请日：2015-09-11
Applicant: GENENTECH, INC.
Inventor： Bing Zheng , Andrew Polson , Cecilia Chiu , Wei-Ching Liang
IPC: C07K16/28 , A61K31/706 , G01N33/574 , A61K31/5517 , A61K51/10 , C07K16/30 , A61K47/48
CPC classification number: C07K16/2851 , A61K31/5517 , A61K31/706 , A61K47/68 , A61K47/6817 , A61K47/6867 , A61K47/6889 , A61K51/1069 , A61K51/1093 , C07K16/3061 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/57426 , G01N2333/7056
Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗CLL-1抗体和免疫缀合物及其使用方法。
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公开(公告)号：US09018357B2
公开(公告)日：2015-04-28
申请号：US13926801
申请日：2013-06-25
Applicant: Genentech, Inc.
Inventor： Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic Fellouse , Sachdev S. Sidhu , Christian Wiesmann
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
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公开(公告)号：US20220251213A1
公开(公告)日：2022-08-11
申请号：US17677283
申请日：2022-02-22
Applicant: Genentech, Inc.
Inventor： Steven R. Leong , Andrew Polson , Paul Polakis , Yan Wu , Wei-Ching Liang , Ron Firestein
IPC: C07K16/28 , A61K47/68 , C07K16/30 , A61K31/404 , A61K31/5517 , A61K31/706 , A61K38/05 , G01N33/574
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US20220162318A1
公开(公告)日：2022-05-26
申请号：US17547528
申请日：2021-12-10
Applicant: Genentech, Inc.
Inventor： Steven R. Leong , Andrew Polson , Paul Polakis , Yan Wu , Wei-Ching Liang , Ron Firestein
IPC: C07K16/28 , A61K47/65 , A61K47/68 , A61K38/08 , A61K39/395 , A61K51/10 , C07K16/30 , G01N33/569
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US11286302B2
公开(公告)日：2022-03-29
申请号：US16043274
申请日：2018-07-24
Applicant: Genentech, Inc.
Inventor： Steven R. Leong , Andrew Polson , Paul Polakis , Yan Wu , Wei-Ching Liang , Ron Firestein
IPC: A61K47/68 , C07K16/28 , C07K16/30 , A61K31/404 , A61K31/5517 , A61K31/706 , A61K38/05 , G01N33/574 , A61K39/00
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US11230600B2
公开(公告)日：2022-01-25
申请号：US16167000
申请日：2018-10-22
Applicant: Genentech, Inc.
Inventor： Steven R. Leong , Andrew Polson , Paul Polakis , Yan Wu , Wei-Ching Liang , Ron Firestein
IPC: C07K16/28 , A61K39/395 , A61K47/68 , G01N33/53 , A61K47/65 , A61K38/08 , A61K51/10 , C07K16/30 , G01N33/569 , A61K39/00
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20190062432A1
公开(公告)日：2019-02-28
申请号：US16043274
申请日：2018-07-24
Applicant: Genentech, Inc.
Inventor： Steven R. Leong , Andrew Polson , Paul Polakis , Yan Wu , Wei-Ching Liang , Ron Firestein
IPC: C07K16/28 , G01N33/574 , C07K16/30 , A61K47/68 , A61K31/404 , A61K31/5517 , A61K31/706 , A61K38/05 , A61K39/00
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20180312586A1
公开(公告)日：2018-11-01
申请号：US15918842
申请日：2018-03-12
Applicant: GENENTECH, INC.
Inventor： Shang-Fan Yu , Wei-Ching Liang , Yan Wu , Steven Leong , Andrew Polson
IPC: C07K16/28 , A61K47/68 , G01N33/574 , A61K39/00
Abstract: The invention provides anti-CD33 antibodies and immunoconjugates and methods of using the same.
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