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    Vagal nerve stimulation techniques for treatment of epileptic seizures
    43.
    发明授权
    Vagal nerve stimulation techniques for treatment of epileptic seizures 有权
    迷走神经刺激技术治疗癫痫发作

    公开(公告)号：US09592003B2

    公开(公告)日：2017-03-14

    申请号：US14679268

    申请日：2015-04-06

    Applicant: FLINT HILLS SCIENTIFIC, L.L.C.

    Inventor： Ivan Osorio ,  Mark Frei

    IPC: A61N1/36 ,  A61B5/00 ,  A61B5/0245 ,  A61B5/0456 ,  A61B5/024 ,  A61B5/0452

    CPC classification number: A61B5/4094 ,  A61B5/02405 ,  A61B5/02455 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/686 ,  A61B5/7282 ,  A61B2560/0475 ,  A61N1/36053 ,  A61N1/36064 ,  A61N1/36114 ,  A61N1/36135

    Abstract: The system, device, and method may use electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as heart rate. The heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. In yet another embodiment, the system, device, and method may be simply a modified pacemaker having circuitry that determines whether a vagus nerve is being stimulated. In the event that the vagus nerve is being stimulated, the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.

    Abstract translation: 系统，装置和方法可以使用迷走神经的电刺激来治疗癫痫，对心脏的影响最小化或没有影响。 治疗由可植入信号发生器，用于电刺激迷走神经的预定刺激部位的一个或多个可植入电极以及用于感测心脏特征的传感器例如心率进行。 来自传感器的心率信息可用于确定迷走神经刺激是否对心脏有不利影响。 一旦达到阈值参数，就可以停止或调整迷走神经刺激。 在另一个实施例中，系统，装置和方法可以简单地是具有确定迷走神经是否被刺激的电路的修改起搏器。 在迷走神经被刺激的情况下，修改的起搏器可以控制心脏在迷走神经刺激期间将其保持在期望的条件下。

    DETECTING, QUANTIFYING, AND/OR CLASSIFYING SEIZURES USING MULTIMODAL DATA
    48.
    发明申请
    DETECTING, QUANTIFYING, AND/OR CLASSIFYING SEIZURES USING MULTIMODAL DATA 审中-公开
    使用多模式数据检测，定量和/或分类

    公开(公告)号：US20150005592A1

    公开(公告)日：2015-01-01

    申请号：US14483979

    申请日：2014-09-11

    Applicant: Flint Hills Scientific, L.L.C.

    Inventor： Ivan Osorio

    IPC: A61B5/00 ,  A61B5/0402 ,  A61B5/113 ,  A61N1/36 ,  A61B5/08

    CPC classification number: A61B5/4094 ,  A61B5/0205 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/02405 ,  A61B5/0245 ,  A61B5/026 ,  A61B5/0402 ,  A61B5/0488 ,  A61B5/0531 ,  A61B5/0816 ,  A61B5/1117 ,  A61B5/113 ,  A61B5/4266 ,  A61B5/686 ,  A61B5/7264 ,  A61B5/746 ,  A61B7/04 ,  A61B8/0883 ,  A61B2562/0219 ,  A61N1/36064 ,  A61N1/36135 ,  A61N1/36139 ,  A61N1/36585

    Abstract: A method, comprising receiving at least one of a signal relating to a first cardiac activity and a signal relating to a first body movement from a patient; triggering at least one of a test of the patient's responsiveness, awareness, a second cardiac activity, a second body movement, a spectral analysis test of the second cardiac activity, and a spectral analysis test of the second body movement, based on at least one of the signal relating to the first cardiac activity and the signal relating to the first body movement; determining an occurrence of an epileptic event based at least in part on said one or more triggered tests; and performing a further action in response to said determination of said occurrence of said epileptic event. Further methods allow classification of epileptic events. Apparatus and systems capable of implementing the method.

    Abstract translation: 一种方法，包括接收与第一心脏活动有关的信号和与来自患者的第一身体运动相关的信号中的至少一个; 基于至少一个，触发对患者的反应性，意识，第二心脏活动，第二身体运动，第二心脏活动的光谱分析测试和第二身体运动的光谱分析测试的测试中的至少一个 关于第一心脏活动的信号和与第一身体运动有关的信号; 至少部分地基于所述一个或多个触发测试来确定癫痫事件的发生; 以及响应所述确定所述癫痫事件的发生而进行进一步的动作。 其他方法可以分类癫痫事件。 能够实施该方法的装置和系统。

    METHOD, APPARATUS AND SYSTEM FOR VALIDATING AND QUANTIFYING CARDIAC BEAT DATA QUALITY
    49.
    发明申请
    METHOD, APPARATUS AND SYSTEM FOR VALIDATING AND QUANTIFYING CARDIAC BEAT DATA QUALITY 有权
    方法，装置和系统，用于验证和量化心脏数据质量

    公开(公告)号：US20140378851A1

    公开(公告)日：2014-12-25

    申请号：US14480406

    申请日：2014-09-08

    Applicant: Flint Hills Scientific, L.L.C.

    Inventor： Mark G. Frei ,  Ivan Osorio

    IPC: A61B5/00 ,  A61B5/024 ,  A61N1/36

    CPC classification number: A61B5/4094 ,  A61B5/02405 ,  A61B5/0245 ,  A61B5/0456 ,  A61N1/36053 ,  A61N1/36064 ,  A61N1/36139

    Abstract: Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test. In one class of beat validity test, a constraint defining a pass is modified at one or more times after the most recent prior valid heart beat that is greater than a constraint modification time threshold

    Abstract translation: 用于量化候选心跳的基准时间标记的质量的方法，系统和装置，量化候选心跳的质量或确定患者心脏的搏动序列的时间。 获得候选心跳的基准时间标记。 将所述候选心跳的质量指标设定为第一值。 通过至少一次拍子有效性测试来测试候选心跳。 如果所述候选心跳通过所述至少一个节拍有效性测试，则至少将第二值添加到所述候选心跳的所述质量指标。 使用至少第二次心跳有效性测试来测试候选心跳。 如果所述候选心跳通过所述至少第二次心跳有效性测试，则至少第三值被添加到所述候选心跳的所述质量指标。 在一类节拍有效性测试中，定义通行证的约束在最近的有效心跳之后的一个或多个时间被修改，其大于约束修改时间阈值

    EPILEPTIC SEIZURE PREVENTION OR TREATMENT VIA HEART RATE CLAMPING
    50.
    发明申请
    EPILEPTIC SEIZURE PREVENTION OR TREATMENT VIA HEART RATE CLAMPING 审中-公开
    通过心率锁定进行预防或治疗

    公开(公告)号：US20140276353A1

    公开(公告)日：2014-09-18

    申请号：US14201609

    申请日：2014-03-07

    Applicant: Flint Hills Scientific, L.L.C.

    Inventor： Ivan Osorio

    IPC: A61M5/172 ,  A61F7/00 ,  A61N1/36

    CPC classification number: A61M5/1723 ,  A61B17/1325 ,  A61F7/007 ,  A61F7/10 ,  A61F7/12 ,  A61F2007/0056 ,  A61F2007/0063 ,  A61F2007/0075 ,  A61F2007/0282 ,  A61F2007/126 ,  A61N1/36053 ,  A61N1/36064

    Abstract: We report a method of treating an epileptic seizure in a patient, comprising: detecting said epileptic seizure, based on body data from said patient; and reducing a flow of blood to a brain of said patient in response to said detected seizure; wherein said reducing is effected by: increasing the parasympathetic input to said patient's heart, such as by electrically stimulating a parasympathetic nervous structure, applying cooling energy to a sympathetic nervous structure, or administering a cholinergic or a sympatho-blocking agent to said patient. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

    Abstract translation: 我们报告一种治疗患者癫痫发作的方法，其包括：基于来自所述患者的身体数据检测所述癫痫发作; 以及响应于所述检测到的癫痫发作，减少所述患者的脑部血液流动; 其中所述还原通过以下方式实现：增加对所述患者心脏的副交感神经输入，例如通过电刺激副交感神经结构，向交感神经结构施加冷却能量，或向所述患者施用胆碱能或交感阻滞剂。 我们还报告配置为实施该方法的医疗设备系统。 我们还报告了一种非暂时性的计算机可读程序存储单元，其中编码有指令，当由计算机执行时，执行该方法。

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