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公开(公告)号：US20240101692A1
公开(公告)日：2024-03-28
申请号：US18267288
申请日：2021-12-29
申请人： CeMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH , MEDIZINISCHE UNIVERSITÄT WIEN , UNIVERSITÉ DE LAUSANNE
IPC分类号： C07K16/28 , A61P3/06 , G01N33/543 , G01N33/68
CPC分类号： C07K16/2875 , A61P3/06 , G01N33/54386 , G01N33/6863 , A61K2039/505 , C07K2317/76 , G01N2800/042 , G01N2800/08 , G01N2800/52
摘要： The present invention relates to an antibody, or an antigen-binding fragment thereof, specifically binding to APRIL for use in the prevention and/or treatment of hypertriglyceridemia, metabolic syndrome, non-alcoholic steatohepatitis, diabetes mellitus type 2, abdominal aortic aneurysm, atherogenic dyslipidemia, cardiovascular events (e.g., myocardial infarction and stroke) and/or atherosclerosis. The invention further relates to a polynucleotide that encodes and/or a pharmaceutical composition that comprises the antibody or an antigen-binding fragment of the invention. The invention also relates to a kit and/or method for quantifying the concentration of nc-APRIL, canonical APRIL or total APRIL in a sample. Further, the invention relates to a nephelometric assay for quantifying nc-APRIL. Further, the invention relates to a method for predicting mortality risk in subjects suffering from, and/or for determining whether a subject is susceptible to the treatment of hypertriglyceridemia, metabolic syndrome, abdominal aortic aneurysm, non-alcoholic steatohepatitis, diabetes mellitus type 2, atherogenic dyslipidemia, cardiovascular events and/or atherosclerosis.
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公开(公告)号：US20240050095A1
公开(公告)日：2024-02-15
申请号：US18266856
申请日：2021-12-16
发明人： Ewald UNGER , Marek EHRLICH , Emilio OSORIO
IPC分类号： A61B17/115 , A61B17/064
CPC分类号： A61B17/115 , A61B17/0644 , A61B2017/1107
摘要： A device for attaching a primary implant as a fixation point for a vascular prosthesis on a vessel wall of a blood vessel, the device at least including a carrier element, which is designed to drive a plurality of penetration elements, for penetrating the vessel wall, radially outwards in relation to a longitudinal axis of the carrier element. In the device, a limiting element is formed on the carrier element as a radial stop for the penetration elements.
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公开(公告)号：US20230341495A1
公开(公告)日：2023-10-26
申请号：US18026740
申请日：2021-09-15
CPC分类号： G01R33/58 , C08K9/10 , C08J3/20 , C08K7/16 , B33Y10/00 , B33Y80/00 , B33Y70/00 , C08K2201/006 , C08K2201/003 , C08J2333/08
摘要： Method for producing a light-curable resin composition capable of producing a magnetic resonance imaging-signal, in particular for the lithography-based additive production of magnetic resonance imaging phantoms, the method comprising at least the following steps: providing particles at least partially filled with a magnetic resonance imaging-signal producing liquid, and mixing the at least partially filled particles with a light-curable resin.
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公开(公告)号：US20220079789A1
公开(公告)日：2022-03-17
申请号：US17415220
申请日：2019-12-19
摘要： A device for feeding and setting an implant into a blood vessel includes a hollow cylindrical portion formed of an expandable wire mesh netting with a first end and a second end, with a sleeve for receiving the implant in a radially compressed state. The sleeve is arrangeable along a guide wire. The sleeve for receiving the implant in the radially compressed state is formed by an inner sleeve, around which at least one outer sleeve with a distal end and a proximal end is arranged. The implant is arranged in the inner sleeve in such a way that the second end of the hollow cylindrical portion is arranged on the end facing the proximal end of the outer sleeve, so that during setting of the implant, the inner sleeve surrounding the implant can be moved into the outer sleeve in the distal direction so that the implant expands, beginning from the second end.
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公开(公告)号：US20220000555A1
公开(公告)日：2022-01-06
申请号：US17280677
申请日：2018-09-28
发明人： Thomas AUZINGER , Philippe DODIER
IPC分类号： A61B34/10 , G06T19/20 , G06T19/00 , G16H30/20 , G16H30/40 , G16H20/40 , G16H50/20 , G16H40/67 , A61F2/28
摘要： Methods and apparatus for designing a skull prosthesis are disclosed. In one arrangement, imaging data from a medical imaging process is received. The imaging data represents the shape of at least a portion of a skull. The imaging data is used to display on a display device a first virtual representation of at least a portion of the skull. User input defining a cutting line in the first virtual representation is received. A surgical operation of cutting through the skull along at least a portion of the defined cutting line to at least partially disconnect a target portion of the skull from the rest of skull is simulated. Output data is provided based on the simulation. The output data represents a simulated shape of at least a portion of the skull with the target portion at least partially disconnected from the rest of the skull, thereby defining the shape of an implantation site for a skull prosthesis to be manufactured.
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公开(公告)号：US20210269882A1
公开(公告)日：2021-09-02
申请号：US17278624
申请日：2019-09-20
IPC分类号： C12Q1/6883 , C12Q1/6886
摘要： The invention relates to an in vitro method of determining a subjects risk of liver dysfunction, specifically after partial liver resection, said method comprising the steps of providing a sample from said subject, determining in said sample the expression level of at least one miRNA, selected from the group consisting of miR-15 la, miR-192 and miR-122, and comparing these expression level(s) with at least one reference expression level, or identifying the ratios of the expression levels of miR-15 la to miR-192 and/or of miR-122 to miR-151a and comparing said expression level ratios with reference expression level ratios, and classifying the sample from the outcome of the comparison into one of at least two classes, wherein each class is one of the at least two categories “high-risk” and “low-risk”.
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公开(公告)号：US20210244312A1
公开(公告)日：2021-08-12
申请号：US16972846
申请日：2019-06-07
摘要： The invention relates to a medical analysis device (1) for assessing a patient's suitability for anaesthesia by analysing at least one physiological biosignal (S) detected during an apnoea, wherein the medical analysis device (1) comprises the following: —an input interface (2) for detecting a time curve of at least one physiological biosignal (S) of a patient, —a computing unit (3) which is configured to compare a time curve of the at least one physiological biosignal (S) with at least one predefinable curve or a limit value according to an algorithm (4) in order to determine a patient's suitability for anaesthesia and to calculate an assessment result (E) depending thereon, wherein the time curve of the at least one physiological biosignal (S) comprises at least the duration of a patient's apnoea, and —an output interface (5) connected to the computing unit (3), to output the assessment result.
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公开(公告)号：US20210085756A1
公开(公告)日：2021-03-25
申请号：US16633610
申请日：2018-07-25
发明人： Reinhold HOFBAUER
摘要： The present invention relates to a mutant thymidine kinase, specifically a mutant human thymidine kinase 1 (Tkl1). The activity of the mutant thymidine kinase is increased compared to the activity of wildtype thymidine kinase. Provided herein are uses of the mutant thymidine kinase in therapy, such as in cancer therapy. Also methods of treating cancer comprising administering the mutant thymidine kinase are disclosed herein. The present invention relates, inter alia, to a nucleic acid for use hi treating cancer, wherein said nucleic acid comprises a nucleotide sequence, wherein said nucleotide sequence encodes a mutant thymidine kinase.
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公开(公告)号：US10358468B2
公开(公告)日：2019-07-23
申请号：US15915318
申请日：2018-03-08
发明人： Johannes Hofer , Peter Steinberger , Gerhard Zlabinger , Georg Böhmig , Florian Forster , Judith Leitner , Markus Wahrmann , Margarethe Merio , Johannes Kovarik , Markus Hölzl , David E. Isenman
摘要： The present invention relates to a pharmaceutical composition comprising complement split product C4d for use in treating an inflammatory condition, such as graft rejection, graft versus host disease, an autoimmune disease or atopy. The C4d to be used may be a multimer. Accordingly, also C4d multimers and their use in medicine, like the treatment of inflammatory conditions, is provided. Furthermore, the present invention provides a protein complex comprising C4d interacting with its ILT4 receptor. This protein complex may be used in screening methods Also antibodies specifically binding to the C4d multimer or the C4d/ILT4-protein complex are subject of the present invention.
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公开(公告)号：US10114100B2
公开(公告)日：2018-10-30
申请号：US15150915
申请日：2016-05-10
IPC分类号： G01R33/565 , G01R33/3415 , G01R33/56
摘要： The present invention relates to a method for Magnetic Resonance Imaging to depict an object by an image having pixels representing volume element of the object. The method comprises: Immobilizing the object and acquiring a reference image at a first echo time immediately following an excitation, wherein said reference image is complex-valued, with a reference magnitude value and a reference phase value for each pixel; acquiring a target image of the object with said receiver coil at a pre-selected second echo time, wherein said target image is complex-valued, with a target magnitude value and a target phase value for each pixel; subtracting, pixel by pixel, the reference phase value from the target phase value to obtain a corrected phase value for each pixel; and obtaining said image from said target magnitude values and said corrected phase values.
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