公开(公告)号：US20180265557A1

公开(公告)日：2018-09-20

申请号：US15915318

申请日：2018-03-08

申请人： Medizinische Universität Wien

发明人： Johannes Hofer ,  Peter Steinberger ,  Gerhard Zlabinger ,  Georg Böhmig ,  Florian Forster ,  Judith Leitner ,  Markus Wahrmann ,  Margarethe Merio ,  Johannes Kovarik ,  Markus Hölzl ,  David E. Isenman

IPC分类号： C07K14/47 ,  A61K38/16 ,  G01N33/50

CPC分类号： C07K14/472 ,  A61K38/16 ,  G01N33/5041 ,  G01N2333/4716 ,  G01N2333/705 ,  G01N2500/02 ,  G01N2500/10

摘要： The present invention relates to a pharmaceutical composition comprising complement split product C4d for use in treating an inflammatory condition, such as graft rejection, graft versus host disease, an autoimmune disease or atopy. The C4d to be used may be a multimer. Accordingly, also C4d multimers and their use in medicine, like the treatment of inflammatory conditions, is provided. Furthermore, the present invention provides a protein complex comprising C4d interacting with its ILT4 receptor. This protein complex may be used in screening methods Also antibodies specifically binding to the C4d multimer or the C4d/ILT4-protein complex are subject of the present invention.

公开(公告)号：US09944685B2

公开(公告)日：2018-04-17

申请号：US14412449

申请日：2013-07-02

申请人： Medizinische Universität Wien

发明人： Johannes Hofer ,  Peter Steinberger ,  Gerhard Zlabinger ,  Georg Böhmig ,  Florian Forster ,  Judith Leitner ,  Markus Wahrmann ,  Margarethe Merio ,  Johannes Kovarik ,  Markus Hölzl ,  David E. Isenman

IPC分类号： A61K38/16 ,  C07K14/47 ,  G01N33/50

CPC分类号： C07K14/472 ,  A61K38/16 ,  G01N33/5041 ,  G01N2333/4716 ,  G01N2333/705 ,  G01N2500/02 ,  G01N2500/10

摘要： The present invention relates to a pharmaceutical composition comprising complement split product C4d for use in treating an inflammatory condition, such as graft rejection, graft versus host disease, an autoimmune disease or atopy. The C4d to be used may be a multimer. Accordingly, also C4d multimers and their use in medicine, like the treatment of inflammatory conditions, is provided. Furthermore, the present invention provides a protein complex comprising C4d interacting with its ILT4 receptor. This protein complex may be used in screening methods Also antibodies specifically binding to the C4d multimer or the C4d/ILT4-protein complex are subject of the present invention.

公开(公告)号：US10358468B2

公开(公告)日：2019-07-23

申请号：US15915318

申请日：2018-03-08

申请人： Medizinische Universität Wien

发明人： Johannes Hofer ,  Peter Steinberger ,  Gerhard Zlabinger ,  Georg Böhmig ,  Florian Forster ,  Judith Leitner ,  Markus Wahrmann ,  Margarethe Merio ,  Johannes Kovarik ,  Markus Hölzl ,  David E. Isenman

IPC分类号： A61K38/00 ,  C07K14/47 ,  A61K38/16 ,  G01N33/50

摘要： The present invention relates to a pharmaceutical composition comprising complement split product C4d for use in treating an inflammatory condition, such as graft rejection, graft versus host disease, an autoimmune disease or atopy. The C4d to be used may be a multimer. Accordingly, also C4d multimers and their use in medicine, like the treatment of inflammatory conditions, is provided. Furthermore, the present invention provides a protein complex comprising C4d interacting with its ILT4 receptor. This protein complex may be used in screening methods Also antibodies specifically binding to the C4d multimer or the C4d/ILT4-protein complex are subject of the present invention.

公开(公告)号：US20150191520A1

公开(公告)日：2015-07-09

申请号：US14412449

申请日：2013-07-02

申请人： Medizinische Universität Wien

发明人： Johannes Hofer ,  Peter Steinberger ,  Gerhard Zlabinger ,  Georg Böhmig ,  Florian Forster ,  Judith Leitner ,  Markus Wahrmann ,  Margarethe Merio ,  Johannes Kovarik ,  Markus Hölzl ,  David E. Isenman

IPC分类号： C07K14/47 ,  G01N33/50

CPC分类号： C07K14/472 ,  A61K38/16 ,  G01N33/5041 ,  G01N2333/4716 ,  G01N2333/705 ,  G01N2500/02 ,  G01N2500/10

摘要： The present invention relates to a pharmaceutical composition comprising complement split product C4d for use in treating an inflammatory condition, such as graft rejection, graft versus host disease, an autoimmune disease or atopy. The C4d to be used may be a multimer. Accordingly, also C4d multimers and their use in medicine, like the treatment of inflammatory conditions, is provided. Furthermore, the present invention provides a protein complex comprising C4d interacting with its ILT4 receptor. This protein complex may be used in screening methodsAlso antibodies specifically binding to the C4d multimer or the C4d/ILT4-protein complex are subject of the present invention.

摘要翻译： 本发明涉及一种药物组合物，其包含用于治疗炎性病症如移植物排斥，移植物抗宿主病，自身免疫疾病或特应性的补体分裂产物C4d。 要使用的C4d可能是多聚体。 因此，还提供了C4d多聚体及其在药物中的用途，如炎症病症的治疗。 此外，本发明提供了包含与其ILT4受体相互作用的C4d的蛋白质复合物。 该蛋白质复合物可以用于筛选方法。此外，与C4d多聚体或C4d / ILT4-蛋白复合体特异性结合的抗体也是本发明的受试者。