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公开(公告)号：US20210100884A1
公开(公告)日：2021-04-08
申请号：US17121818
申请日：2020-12-15
Inventor： Masaki ITO , Kiyotaka SHIBA
Abstract: A novel vaccine that can induce sufficiently high cell-mediated immunity is disclosed. The vaccine of the present invention contains, as an effective component, a polypeptide comprising a tandem repeat structure in which an MHC class I epitope region derived from an antigen protein and a spacer sequence are linked to each other alternately and repeatedly at least three times, or a recombinant vector which comprises a polynucleotide encoding said polypeptide and is capable of expressing said polypeptide in vivo. The spacer sequence is, for example, a sequence generated as an amino acid sequence inevitably encoded by a single base sequence which is designed such that the MHC class I epitope region derived from the antigen protein, an MHC class II epitope region derived from the antigen protein, and at least one higher-order-structure-stabilizing region are encoded by different reading frames in said single base sequence.
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公开(公告)号：US10898555B2
公开(公告)日：2021-01-26
申请号：US14901384
申请日：2014-06-30
Inventor： Masaki Ito , Kiyotaka Shiba
Abstract: A novel vaccine that can induce sufficiently high cell-mediated immunity is disclosed. The vaccine of the present invention contains, as an effective component, a polypeptide comprising a tandem repeat structure in which an MHC class I epitope region derived from an antigen protein and a spacer sequence are linked to each other alternately and repeatedly at least three times, or a recombinant vector which comprises a polynucleotide encoding said polypeptide and is capable of expressing said polypeptide in vivo. The spacer sequence is, for example, a sequence generated as an amino acid sequence inevitably encoded by a single base sequence which is designed such that the MHC class I epitope region derived from the antigen protein, an MHC class II epitope region derived from the antigen protein, and at least one higher-order-structure-stabilizing region are encoded by different reading frames in said single base sequence.
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公开(公告)号：US20190324023A1
公开(公告)日：2019-10-24
申请号：US15958241
申请日：2018-04-20
Inventor： Yuki Ichikawa , Kiyotaka Shiba , Sachiko Matsumura
IPC: G01N33/543
Abstract: The present disclosure provides examples of methods and kits for easily detecting, classifying and/or purifying extracellular vesicles. The method can include subjecting, to a density gradient centrifugation, a sample solution in which the extracellular vesicles and nanoparticles coated with ligand that specifically binds to molecule present on the surface of the extracellular vesicles are mixed.
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公开(公告)号：US10223765B2
公开(公告)日：2019-03-05
申请号：US14424222
申请日：2013-08-23
Applicant: Sony Corporation , Japanese Foundation For Cancer Research
Inventor： Takeshi Ohashi
Abstract: Provided is an information processing apparatus including an image supply unit that supplies a plurality of input images showing corresponding objects to an image processing unit and obtains a plurality of object images as an image processed result from the image processing unit, and a display control unit that synchronously displays the plurality of object images that have been obtained. The object images are regions including the corresponding objects extracted from the plurality of input images, and orientations, positions, and sizes of the corresponding objects of the plurality of object images are unified.
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45.发明申请公开(公告)号：US20180113131A1
公开(公告)日：2018-04-26
申请号：US15569898
申请日：2016-04-28
Applicant: KYOTO UNIVERSITY , JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Seishi OGAWA , Keisuke KATAOKA , Kengo TAKEUCHI
IPC: G01N33/574 , C07K16/28
Abstract: An object of the present invention is to provide an effective method of predicting an effect of treatment by a PD-1/PD-L1 blockade, which is a method of predicting whether or not PD-1/PD-L1 blockade is effective for treatment of a subject suffering from a malignant tumor, which comprises detecting abnormality of genome relating to effectiveness of the PD-1/PD-L1 blockade in a tumor cell taken from the subject and evaluating the PD-1/PD-L1 blockade as useful for the treatment of the subject when there is the abnormality.
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Patent Agency Ranking
公开(公告)号：US09856507B2
公开(公告)日：2018-01-02
申请号：US14767166
申请日：2014-02-10
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Eiji Hara , Naoko Ohtani , Shin Yoshimoto , Tze Mun Loo
CPC classification number: C12Q1/18 , C12Q1/025 , G01N33/02 , G01N33/5011 , G01N2333/33
Abstract: The present invention provides a method for screening for a food ingredient or a food composition that reduces a cancer risk and inhibits cancer development. A substance that reduces a cancer risk is screened by administering a candidate substance and analyzing alteration in gut microbiota or a metabolite produced by an intestinal bacterium. Also, candidate substances are screened by adding each candidate substance to a bacterial culture system and analyzing its effect on a bacterium involved in cancer development.
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公开(公告)号：US20170233766A1
公开(公告)日：2017-08-17
申请号：US15430821
申请日：2017-02-13
Applicant: Research Foundation of the City University of New York , Japanese Foundation for Cancer Research
Inventor： Hiroshi Matsui , Kiyotaka Shiba
IPC: C12P1/00
CPC classification number: C07K14/705 , C07K5/06078 , C07K5/0812 , C07K5/1016 , C07K7/00 , C07K7/06 , C07K7/08 , C12N5/0006 , C12P21/00
Abstract: A method for enhancing extracellular vesicle production is described. A peptide that induces polymer formation is incubated with a cell culture which results in enhanced EV production. The peptide penetrates the cells and subsequently polymerizes upon exposure to enzymes (e.g. phosphatase) within the cell. The cells that contain the newly formed polymers have an increased production of EVs. These EVs can be harvested using centrifugation techniques.
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公开(公告)号：US20170143049A1
公开(公告)日：2017-05-25
申请号：US15323901
申请日：2015-07-03
Inventor： Masahiko Oguchi , Shiho Goto , Emiko Ishikawa , Shinya Komori , Yukari Hattori , Shou Miyazaki
CPC classification number: A41C3/0064 , A41B2400/34 , A41B2400/36 , A41B2500/10 , A41C3/0035 , A41C3/02 , A41C3/08 , A41C3/144 , A41D13/1245 , A41D31/30 , D04B1/18 , D04B1/24 , D10B2509/02
Abstract: Clothing uses a knitted fabric made from a composite thread of elastic fibers and synthetic fibers, wherein the elongation rates in the longitudinal and lateral directions as measured in accordance with the grab method of JIS-L-1096 are 160% or more and less than 250%, and the weight per unit area is 90 g/m2 or more and less than 160 g/m2. The clothing is suitable for use by patients having skin inflammations, has a comfortable texture using a knitted fabric that is light and has a high elongation rate, and does not allow seepage of medicaments or infusions.
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公开(公告)号：US20160002699A1
公开(公告)日：2016-01-07
申请号：US14767166
申请日：2014-02-10
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Eiji Hara , Naoko Ohtani , Shin Yoshimoto , Tze Mun Loo
CPC classification number: C12Q1/18 , C12Q1/025 , G01N33/02 , G01N33/5011 , G01N2333/33
Abstract: The present invention provides a method for screening for a food ingredient or a food composition that reduces a cancer risk and inhibits cancer development. A substance that reduces a cancer risk is screened by administering a candidate substance and analyzing alteration in gut microbiota or a metabolite produced by an intestinal bacterium. Also, candidate substances are screened by adding each candidate substance to a bacterial culture system and analyzing its effect on a bacterium involved in cancer development.
Abstract translation: 本发明提供了一种筛选降低癌症风险并抑制癌症发展的食品成分或食品组合物的方法。 通过施用候选物质和分析肠道细菌产生的肠道微生物群或代谢物的改变来筛选降低癌症风险的物质。 此外，通过将每种候选物质加入到细菌培养系统中并分析其对涉及癌症发展的细菌的影响来筛选候选物质。
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公开(公告)号：US20150376716A1
公开(公告)日：2015-12-31
申请号：US14767169
申请日：2014-02-10
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Eiji Hara , Naoko Ohtani , Shin Yoshimoto , Tze Mun Loo
IPC: C12Q1/68 , G01N33/574
CPC classification number: C12Q1/6886 , A61K31/4164 , A61K31/43 , A61K31/496 , A61K31/7036 , C12Q1/025 , C12Q1/689 , C12Q2600/136 , C12Q2600/158 , G01N33/57484 , G01N2333/33 , G01N2500/10
Abstract: The present invention provides a method capable of detecting a cancer and/or a carcinogenic risk, and a reagent for the detection thereof. The present invention also provides a method for screening for a pharmaceutical drug for reducing a carcinogenic risk and a pharmaceutical composition. Since cancer development closely correlates with alteration in gut microbiota, cancer development and/or a risk of cancer development are detected by detecting alteration in gut microbiota and a secondary bile acid produced by an intestinal bacterium. The present invention further provides a method for screening for a pharmaceutical drug with a gut microbiota as an index, and a pharmaceutical composition.
Abstract translation: 本发明提供能够检测癌症和/或致癌风险的方法和用于检测癌症的试剂。 本发明还提供了用于筛选用于降低致癌风险的药物的药物组合物的方法。 由于癌症发展与肠道微生物群的改变密切相关，通过检测肠道细菌产生的肠道微生物群和次级胆汁酸的变化来检测癌症发展和/或癌症发展的风险。 本发明还提供了以肠微生物群作为指标筛选药物的药物组合物的方法。
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