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41.
公开(公告)号:US12153043B2
公开(公告)日:2024-11-26
申请号:US17184405
申请日:2021-02-24
Applicant: Becton, Dickinson and Company
Inventor: Jody Martin , James Ghadiali , Mirko Corselli , Adam Wright , Aaron Jacob Tyznik
IPC: G01N33/53
Abstract: Disclosed herein include methods, compositions, and kits suitable for spectral unmixing and compensation in multi-parameter flow cytometry. Disclosed herein include reagents which comprise two antibodies conjugated to one another to form a bispecific reagent (e.g., a bispecific probe). A first antibody can have affinity for a highly expressed antigen on the surface of a cell of interest and a second antibody can have affinity for each of the antibody-dye conjugates in a multi-parameter panel. There are provided, in some embodiments, methods of using the bispecific reagent to determine spillover, perform compensation, and generate a compensation matrix.
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公开(公告)号:US12150912B2
公开(公告)日:2024-11-26
申请号:US17151512
申请日:2021-01-18
Applicant: Becton Dickinson and Company Ltd.
Inventor: Milan Ivosevic , Paul Paia Marici
Abstract: A connection system for connecting a first medical device component to a second medical device component is disclosed. The connection system of the present disclosure provides for quick and intuitive coupling and decoupling of two opposing medical device components through the use of a connection path and a disconnection path, the connection path being distinct from the disconnection path. Furthermore, the connection system of the present disclosure provides audible and tactile connection feedback through the use of elastically deformable connection elements.
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公开(公告)号:US20240384354A1
公开(公告)日:2024-11-21
申请号:US18687030
申请日:2022-08-31
Applicant: Becton, Dickinson and Company
Inventor: Hye-Won Song , Jody Martin , Margaret Nakamoto
IPC: C12Q1/6886 , C12N15/10 , C12Q1/682 , C12Q1/6834 , C12Q1/6841 , C12Q1/6874 , C12Q1/6881
Abstract: Disclosed herein include systems, methods, compositions, and kits for determining the spatial location and copy number of targets (e.g., nucleic acid targets, cellular component targets) in a sample. There are provided, in some embodiments, substrates comprising a plurality of spatial regions. A plurality of oligonucleotide barcodes can be associated with each of the spatial regions and can comprise a predetermined spatial label. Oligonucleotide barcodes of the same spatial region can comprise the same spatial label, and oligonucleotide barcodes of the different spatial regions can comprise different spatial labels. The method can comprise contacting the substrate with a sample such that each distinct spatial region contacts a distinct spatial location of the sample. The method can comprise in situ extension (e.g., reverse transcription) of the oligonucleotide barcodes.
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公开(公告)号:US20240369587A1
公开(公告)日:2024-11-07
申请号:US18688421
申请日:2022-09-06
Applicant: BECTON, DICKINSON AND COMPANY
Inventor: Stephen Robert LaChance , Gerard J. Lotz , Philip Thomas Miller
Abstract: An analyzer for analysis of a biological sample prepared by a pre analytical system and a method of operating an analyzer that received samples prepared by a pre-analytical system. The analyzer is automated and has a processing deck with a plurality of modules serviced by a plurality of multichannel pipettors. Due to the high volume of pipette tips used by and dispensed from the multichannel pipettors, the processing deck has a pipette dispense assembly having a plurality of chutes, so that a multichannel pipettor does not need to wait to discard a pipette tip into a chute. The plurality of chutes allows the pipette tips to fall therethrough to a waste receptacle below the processing deck. The processing deck also includes a plurality of drawers that contain bins for consumable pipette tips to be used by the multichannel pipettors. Some of the drawers have multiple bins and some have only one bin because the location of the chutes does not permit all drawers to have the same depth.
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公开(公告)号:USD1050149S1
公开(公告)日:2024-11-05
申请号:US29771330
申请日:2021-02-22
Applicant: Becton, Dickinson and Company
Designer: Leslie Wilson , Zachary Wentworth , Thomas James Klemz
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公开(公告)号:US12135274B2
公开(公告)日:2024-11-05
申请号:US17867394
申请日:2022-07-18
Applicant: Becton, Dickinson and Company
Inventor: Kyle Dembski
IPC: G01N15/1434 , G01N15/10 , G01N15/1404 , G01N33/487
Abstract: Outlet fittings are provided. Outlet fittings of interest include an elongate structure and an opening at a proximal end for receiving a flow stream from the distal end of a flow cell. In addition, the outlet fittings described herein are configured to reduce the formation of bubbles at the interface between the outlet fitting and the flow cell. In certain cases, outlet fittings do not include a planar surface in contact with the received flow stream. Flow cytometers and methods employing the subject outlet fittings are also provided.
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公开(公告)号:US20240358966A1
公开(公告)日:2024-10-31
申请号:US18139409
申请日:2023-04-26
Applicant: Becton, Dickinson and Company
Inventor: Srinath B , Karthik MR , Balaji K , Stephen Robert Cassidy , Jonathan Karl Burkholz , S. Ray Isaacson
CPC classification number: A61M25/0026 , A61B5/15003 , A61B5/150992 , A61M25/0606 , A61M39/10 , A61M39/22 , A61M2039/229
Abstract: Provided herein is a catheter system including a catheter having a catheter distal end and a catheter proximal end, with the catheter defining a catheter lumen. The catheter system also includes a catheter hub coupled to the catheter proximal end, with the catheter hub further including a hub body having a hub distal end and a hub proximal end, the hub body having a cavity formed therein extending between the hub distal end and the hub proximal end. The catheter hub also includes an end port positioned at the hub proximal end and that provides an opening into the cavity. A split-septum connector of the catheter system is positioned at least partially within the end port, with the split-septum connector configured to seal the cavity when in a closed configuration and provide a fluid path to the catheter lumen when in an open configuration.
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公开(公告)号:US20240358897A1
公开(公告)日:2024-10-31
申请号:US18140510
申请日:2023-04-27
Applicant: Becton, Dickinson and Company
Inventor: David Colton Jackson , James Freasier , Ejaz Sajedul Haque
IPC: A61L29/08
CPC classification number: A61L29/085 , A61L2300/104 , A61L2300/25 , A61L2300/252 , A61L2300/404 , A61L2300/442 , A61L2300/606 , A61L2420/02 , A61L2420/04
Abstract: A medical device having resistance to Candida albicans yeast and antimicrobial activity includes a medical device surface having a copolymer coating of antifungal moieties and ionic binding moieties. The copolymer coating is obtained by copolymerizing antifungal monomers selected from tricyclodecane dimethanol diacrylate, 4-tert-butylcyclohexyl acrylate, neopentyl glycol diacrylate, trimethylcyclohexyl methacrylate, isobornyl acrylate, and mixtures thereof and ionic binding monomers selected from acrylic acid, methyl acrylate, and mixtures thereof. The coating may be loaded with elutable antimicrobial substances ionically bound to the ionic binding moieties. The antimicrobial substances may be cationic, such as, a cationic dye such as ethyl violet chloride, a cationic drug such as chlorhexidine diacetate, cationic peptides such as cecropins, magainins, protegrins, and bactenicins, or ionic silver. The medical device may be a catheter having an intraluminal surface and an extraluminal surface, and the copolymer coating is disposed on the intraluminal surface and the extraluminal surface.
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公开(公告)号:US20240358296A1
公开(公告)日:2024-10-31
申请号:US18643525
申请日:2024-04-23
Applicant: Becton, Dickinson and Company
Inventor: Praveen Nalawade , Manish Kumar , Karthik MR , Shishir Prasad
IPC: A61B5/15
CPC classification number: A61B5/150328 , A61B5/15003 , A61B5/150274
Abstract: Provided herein is an instrument delivery device including an instrument, a housing having a proximal end and a distal end and defining an inner volume configured to movably receive the instrument, a coupling device positioned at the distal end of the housing and including a lock configured to couple the housing to a proximal connector of the catheter assembly, and an advancement member configured to move relative to the housing to move the instrument between a first position and a second position. A scrubbing cap is engaged with the lock that includes a scrubbing insert, a housing having a connector portion configured to engage with the lock, a holder portion configured to retain the scrubbing insert therein, and a seal that seals the scrubbing insert within the holder portion. The scrubbing cap is engaged with the lock so as to be removable from the instrument delivery device.
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50.
公开(公告)号:US12131210B2
公开(公告)日:2024-10-29
申请号:US18027000
申请日:2021-09-15
Applicant: Becton Dickinson France , Becton, Dickinson and Company
Inventor: Cédric Rivier , Nicolas Euvrard
IPC: G06K19/077
CPC classification number: G06K19/07758 , G06K19/07773
Abstract: A medical container including a tubular barrel defining a reservoir for a medical product. The barrel is provided with a scale having graduations indicative of an injected volume or a remaining volume of said medical product. The barrel further includes a RFID tag including an antenna that forms, follows or overlays with at least a portion of the scale.
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