公开(公告)号：US20240358897A1

公开(公告)日：2024-10-31

申请号：US18140510

申请日：2023-04-27

Applicant: Becton, Dickinson and Company

Inventor： David Colton Jackson ,  James Freasier ,  Ejaz Sajedul Haque

IPC: A61L29/08

CPC classification number: A61L29/085 ,  A61L2300/104 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/442 ,  A61L2300/606 ,  A61L2420/02 ,  A61L2420/04

Abstract: A medical device having resistance to Candida albicans yeast and antimicrobial activity includes a medical device surface having a copolymer coating of antifungal moieties and ionic binding moieties. The copolymer coating is obtained by copolymerizing antifungal monomers selected from tricyclodecane dimethanol diacrylate, 4-tert-butylcyclohexyl acrylate, neopentyl glycol diacrylate, trimethylcyclohexyl methacrylate, isobornyl acrylate, and mixtures thereof and ionic binding monomers selected from acrylic acid, methyl acrylate, and mixtures thereof. The coating may be loaded with elutable antimicrobial substances ionically bound to the ionic binding moieties. The antimicrobial substances may be cationic, such as, a cationic dye such as ethyl violet chloride, a cationic drug such as chlorhexidine diacetate, cationic peptides such as cecropins, magainins, protegrins, and bactenicins, or ionic silver. The medical device may be a catheter having an intraluminal surface and an extraluminal surface, and the copolymer coating is disposed on the intraluminal surface and the extraluminal surface.

公开(公告)号：US20240342503A1

公开(公告)日：2024-10-17

申请号：US18133927

申请日：2023-04-12

Applicant: Becton, Dickinson and Company

Inventor： Amanda Lingle ,  Megan Brooks ,  Morgan Izykowski ,  David Colton Jackson ,  Joseph Aamodt

IPC: A61N5/06 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0538 ,  A61B5/145

CPC classification number: A61N5/0624 ,  A61B5/01 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/6852 ,  A61N5/0601 ,  A61N2005/063 ,  A61N2005/0651

Abstract: An indwelling medical device with stimuli-responsive antimicrobial properties. The medical device includes a polymeric substrate having one or more light-responsive antimicrobial compounds. The medical device includes a light source to provide light to the polymeric substrate and a sensor to detect infection or bacterial colonization. A controller is connected to the light source and to the sensor. The controller controls operation of the sensor and receives sensing signals from the sensor. The controller activates the light source in response to infection detection and release the antimicrobial compound. The light-responsive antimicrobial compound may include a nitric oxide donor, such as S-nitroso-n-acetylpenacillamine, S-nitrosoglutathione, or N-diazeniumdiolate (NONOate). The light-responsive antimicrobial compound may include a photocatalyst metal oxide, such as ZnO, CuO, or TiO2. The light-responsive antimicrobial compound may include a photosensitive dye, such as crystal violet, methylene blue ethyl violet, rose bengal, or malachite green.