公开(公告)号：US20240342503A1

公开(公告)日：2024-10-17

申请号：US18133927

申请日：2023-04-12

Applicant: Becton, Dickinson and Company

Inventor： Amanda Lingle ,  Megan Brooks ,  Morgan Izykowski ,  David Colton Jackson ,  Joseph Aamodt

IPC: A61N5/06 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0538 ,  A61B5/145

CPC classification number: A61N5/0624 ,  A61B5/01 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/6852 ,  A61N5/0601 ,  A61N2005/063 ,  A61N2005/0651

Abstract: An indwelling medical device with stimuli-responsive antimicrobial properties. The medical device includes a polymeric substrate having one or more light-responsive antimicrobial compounds. The medical device includes a light source to provide light to the polymeric substrate and a sensor to detect infection or bacterial colonization. A controller is connected to the light source and to the sensor. The controller controls operation of the sensor and receives sensing signals from the sensor. The controller activates the light source in response to infection detection and release the antimicrobial compound. The light-responsive antimicrobial compound may include a nitric oxide donor, such as S-nitroso-n-acetylpenacillamine, S-nitrosoglutathione, or N-diazeniumdiolate (NONOate). The light-responsive antimicrobial compound may include a photocatalyst metal oxide, such as ZnO, CuO, or TiO2. The light-responsive antimicrobial compound may include a photosensitive dye, such as crystal violet, methylene blue ethyl violet, rose bengal, or malachite green.