公开(公告)号：US11337680B2

公开(公告)日：2022-05-24

申请号：US16484731

申请日：2017-09-21

申请人： Hangzhou New Horizon Health Technology Co. Ltd.

发明人： Yiyou Chen ,  Bin Li ,  Shuidi Zhong

IPC分类号： G01N33/72 ,  G01N33/49 ,  G01N1/02 ,  A61B10/00

摘要： Disclosed is an integrated device for faeces sampling and occult blood detection, which has functions of quantitative collection, dissolution, filtration, detection with immune test strips of the faecal sample, and is convenient to carry and operate, and the device does not leak any liquid during storage, transportation and detection. The device can accurately collect a constant sample with no pollution and leakage, and can quickly determine results of occult blood without the aid of other items. The device can detect faecal occult blood at any time and at any place, can help to overcome the problem of low rate of inspection due to the inconvenience of faeces submission and inspection, further promote the detection of faecal occult blood, and can improve the early diagnosis and screening rate of colorectal cancer of the population.

公开(公告)号：US11319571B2

公开(公告)日：2022-05-03

申请号：US15905894

申请日：2018-02-27

申请人： The General Hospital Corporation

发明人： John M. Higgins

IPC分类号： C12Q1/02 ,  G01N33/72 ,  G01N33/80 ,  G01N33/94 ,  G01N33/68

摘要： Methods for identifying patients with anemia, distinguishing thalassemia-trait anemia from iron-deficiency anemia, and identifying pre-anemic patients several weeks before anemia becomes clinically detectable. Also, methods for detecting blood doping in athletes and for optimizing therapy with erythropoiesis stimulating agents or iron supplementation. Computer-readable storage devices and systems, e.g., for use in the described methods.

公开(公告)号：US20220113302A1

公开(公告)日：2022-04-14

申请号：US17561823

申请日：2021-12-24

申请人： CHENGDU SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY RESEARCH INSTITUTE CO., LTD. ,  SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.

发明人： Wenjun Tong ,  Yijie Yang ,  Huaming Xu ,  Xing Shi

IPC分类号： G01N33/50 ,  G01N1/38 ,  G01N33/72 ,  G01N35/00 ,  G01N35/10 ,  G01N15/14 ,  G01N1/18 ,  G01N15/10 ,  G01N15/00 ,  G01N15/05

摘要： The present disclosure provided a blood cell analyzer, a control device and a blood analysis method thereof. In the method, a first reagent is mixed with a sample to obtain a first testing sample, and then a second reagent is mixed with the first testing sample for a further reaction to get a second testing sample for basophil classification and/or HGB measurement. A blood sample may be tested in one reaction cell through time-division multiplexing technology to obtain four groups leukocytes classification result and HGB result by single detection channel. Thus, the structure of the analyzer may be greatly simplified on the premise of guaranteeing the performance of the analyzer, the size and cost of the analyzer may reduce and a performance-price ratio of the analyzer may increase.

公开(公告)号：US11168349B2

公开(公告)日：2021-11-09

申请号：US16319853

申请日：2017-07-28

申请人： Hitachi Chemical Diagnostics Systems Co., Ltd.

发明人： Haruyo Soya ,  Yuki Katayama ,  Noriyuki Ogawa

IPC分类号： C12Q1/28 ,  G01N33/72 ,  C12Q1/26

摘要： A method is provided for measuring glycated hemoglobin in a hemoglobin-containing sample which comprises reacting glycated hemoglobin in the hemoglobin-containing sample with an enzyme that catalyzes a reaction of oxidizing the glycated hemoglobin to generate hydrogen peroxide, in the presence of at least one anionic surfactant selected from the group consisting of N-acyl taurine in which a hydrogen atom of the amino group may be substituted with a substituent, alkyl sulfoacetic acid, polyoxyethylene alkyl ether acetic acid, N-acyl amino acid in which a hydrogen atom of the amino group may be substituted with a substituent, polyoxyethylene alkyl ether phosphoric acid, polyoxyethylene polycyclic phenyl ether phosphoric acid, alkyl phosphoric acid, and salts thereof, to generate hydrogen peroxide, and measuring the generated hydrogen peroxide.

公开(公告)号：US20210333291A1

公开(公告)日：2021-10-28

申请号：US17370180

申请日：2021-07-08

申请人： Roche Diagnostics Operations, Inc.

发明人： Uwe KOBOLD ,  Andreas LEINENBACH ,  Indranil MITRA ,  Holger BUSSKAMP

IPC分类号： G01N33/72 ,  G01N33/68

摘要： The present invention refers to a method for determining intact glycated hemoglobin A (HbA1c) by mass spectrometry (MS), a kit and a diagnostic system adapted for performing the method.

公开(公告)号：US20210333290A1

公开(公告)日：2021-10-28

申请号：US17370170

申请日：2021-07-08

申请人： Roche Diagnostics Operations, Inc.

发明人： Uwe KOBOLD ,  Andreas LEINENBACH ,  Indranil MITRA

IPC分类号： G01N33/72 ,  G01N33/68

摘要： The present invention refers to a method for determining peptide fragments of glycated hemoglobin A (HbA1c) molecules by mass spectrometry (MS), a reagent kit, and a clinical diagnostic system adapted for performing the method.

公开(公告)号：US20210270850A1

公开(公告)日：2021-09-02

申请号：US17254609

申请日：2019-06-27

申请人： Calmark Sweden AB

发明人： Anna SÖDERLUND ,  Tania CORREIA ,  Anders ABJÖRNSSON ,  Johan SVAHN ,  Catarina MOREIRA PINHO ,  Ana Catarina DE ARAÚJO SILVA ,  Michael LUNDH

IPC分类号： G01N33/72 ,  B01L3/00

摘要： A detector assembly and method of detecting the presence of a biomarker, such as bilirubin, in a sample of a flowable substance and a detector unit (1) are disclosed. The method comprises providing a receiver body (2) shaped to define a receiving chamber (3). The receiving chamber (3) has an outlet opening (5) through which a flowable substance can leave the receiving chamber (3). The receiving chamber (3) has a maximum capacity for holding a volume of the flowable substance. A quantity of the flowable substance is supplied to the receiving chamber (3) and caused to pass through the outlet opening. The receiver body (2) can move relative to a guide (10) of the receive body (2) from a first position in which the outlet opening (5) is blocked to a second position in which the outlet opening (5) is not blocked. In the second position, a metered quantity of flowable substance in the receiving chamber (3) can leave the receiving chamber (3).

公开(公告)号：US20210239717A1

公开(公告)日：2021-08-05

申请号：US17269926

申请日：2019-08-21

申请人： Quest Diagnostics Investments LLC

发明人： Nigel Clarke ,  Mildred Goldman ,  Jueun Kim ,  Jane Yang

IPC分类号： G01N33/72

摘要： The present disclosure relates to methods of detecting various analytes, including glycated hemoglobin (HbA1c) and total hemoglobin (THb), in a biological sample obtained with a microsampling device.

公开(公告)号：US11079370B2

公开(公告)日：2021-08-03

申请号：US15747140

申请日：2016-05-31

申请人： KYOCERA CORPORATION

发明人： Kyosuke Kishimoto ,  Hideharu Kurioka ,  Atsuomi Fukuura

IPC分类号： G01N33/53 ,  G01N33/566 ,  G01N33/543 ,  G01N33/72 ,  G01N29/44 ,  G01N27/414 ,  G01N29/02 ,  G01N33/68 ,  G01N21/552

摘要： A measurement method includes a measurement step of measuring a first single value and a second signal value, the first signal value being based on a reaction between a first reacting substance and the sample, the second signal value being based on a reaction between a second reacting substance and the sample, the first reacting substance having a higher reactivity to a second detection target than to a first detection target, the second reacting substance having a higher reactivity to the first detection target than to the second detection target.

公开(公告)号：US20210199674A1

公开(公告)日：2021-07-01

申请号：US17116059

申请日：2020-12-09

申请人： ARKRAY, Inc.

发明人： Yusuke NAKAYAMA

IPC分类号： G01N33/72 ,  G01N30/02

摘要： A flow path for liquid chromatography, which analyzes hemoglobin within a blood sample, is subjected to a surface treatment with a liquid in which is dissolved a surface treating agent having a molecular weight of 200 or less and having two or more chemical structures in each of which a hydroxy group (—OH) and an oxo group (═O) are respectively bonded directly to one phosphor (P) atom.