公开(公告)号：US11667705B2

公开(公告)日：2023-06-06

申请号：US16843474

申请日：2020-04-08

Applicant: Crescendo Biologics Limited

Inventor： Bryan Edwards ,  Ulla Lashmar ,  Brian McGuinness ,  Mike Romanos ,  Thomas Sandal ,  Yumin Teng

IPC: C07K16/24 ,  A61K39/395 ,  A01K67/027 ,  C12N15/63 ,  A61P37/02 ,  A61P31/00 ,  A61P37/06 ,  A61P37/08 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/244 ,  A01K67/0278 ,  A61K39/3955 ,  A61P31/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  C12N15/63 ,  G01N33/6869 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92 ,  G01N2333/54

Abstract: Binding molecules to IL-17A. The binding molecules are useful in the treatment of disorders, for example psoriasis.

公开(公告)号：US20190239497A1

公开(公告)日：2019-08-08

申请号：US16244912

申请日：2019-01-10

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Lynn Macdonald ,  Andrew J. Murphy ,  Naxin Tu ,  Cagan Gurer ,  Vera Voronina ,  Sean Stevens

IPC: A01K67/027 ,  C07K14/74

CPC classification number: A01K67/0278 ,  A01K67/0271 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C07H21/04 ,  C07K14/70539 ,  C12N15/8509

Abstract: The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.

公开(公告)号：US20190230907A1

公开(公告)日：2019-08-01

申请号：US16261065

申请日：2019-01-29

Applicant: INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION

Inventor： Burcin Ekser

IPC: A01K67/027 ,  A61K35/12 ,  A61P43/00

CPC classification number: A01K67/0278 ,  A01K2207/15 ,  A01K2217/15 ,  A01K2227/108 ,  A01K2267/025 ,  A61K35/12 ,  A61P43/00

Abstract: Provided herein are genetically modified pigs, porcine organs, tissue, and cells having a reduced propensity to cause a rejection response in a human subject following xenotransplantation. In particular, provided herein are genetically modified pigs lacking nonGal xenoantigens, and porcine cells, tissues, and organs obtained from such genetically modified pigs that are suitable for transplantation into a human. Also provided herein are methods of improving a rejection related symptom in a human subject.

公开(公告)号：US20190192518A1

公开(公告)日：2019-06-27

申请号：US16086143

申请日：2017-03-17

Applicant: TUFTS MEDICAL CENTER

Inventor： Miaofen G. HU

IPC: A61K31/519 ,  A61P3/04

CPC classification number: A61K31/519 ,  A01K67/0276 ,  A01K67/0278 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0362 ,  A61K31/506 ,  A61K45/06 ,  A61P3/04 ,  C12N15/1135 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2740/16043 ,  C12N2740/16052 ,  C12N2800/30 ,  C12Y207/11022

Abstract: Provided herein are compositions and methods for treating or preventing metabolic disorders. In particular, provided herein are compositions, methods, and uses of Cyclin-dependent Kinase 6 (CDK6) inhibitors for treating and preventing metabolic diseases (e.g., type II diabetes, obesity, metabolic syndrome, elevated blood pressure, cardiovascular diseases, elevated fasting plasma glucose, and high serum triglycerides).

公开(公告)号：US20190183102A1

公开(公告)日：2019-06-20

申请号：US16178949

申请日：2018-11-02

Applicant: Universite de Paris - Sud ,  Universite Paris Descartes

Inventor： Nathalie Cartier-Lacave ,  Jerome Braudeau ,  Nicole Deglon ,  Philippe Hantraye ,  Mickael Audrain

IPC: A01K67/027 ,  G01N33/50 ,  C12N15/85 ,  C12N15/86

CPC classification number: A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0312 ,  A01K2267/0318 ,  C07K14/4711 ,  C12N15/8509 ,  C12N15/86 ,  C12N2015/8545 ,  C12N2750/14143 ,  G01N33/5088 ,  G01N2333/47

Abstract: The present invention relates to a vector comprising a nucleic acid sequence that encodes the APP protein and/or the PS1 protein or variants thereof. The invention also relates to a method for inducing the Alzheimer's disease in an animal using the vector of the invention and to animal model having the Alzheimer's disease obtained by said method.

公开(公告)号：US20190183101A1

公开(公告)日：2019-06-20

申请号：US16324685

申请日：2017-08-11

Applicant: The Jackson Laboratory

Inventor： Leonard D. Shultz ,  Michael V. Wiles

IPC: A01K67/027 ,  A61K49/00

CPC classification number: A01K67/0276 ,  A01K67/027 ,  A01K67/0271 ,  A01K67/0278 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2207/20 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/0306 ,  A01K2267/0337 ,  A61K49/0008 ,  C12N15/63

Abstract: A genetically modified immunodeficient non-human animal whose genome includes a genetic modification that renders the non-human animal deficient in macrophages and/or macrophage anti-human red blood cell activity so as to prolong the survival of human red blood cells when administered into said non-human animal is provided according to aspects of the present invention. Methods of assaying effects of putative therapeutic agents in such a genetically modified immunodeficient non-human animal are provided by the present invention.

公开(公告)号：US20180346599A1

公开(公告)日：2018-12-06

申请号：US16059922

申请日：2018-08-09

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Lynn Macdonald ,  Sean Stevens ,  Andrew J. Murphy ,  Margaret Karow

IPC: C07K16/40 ,  A01K67/027 ,  C07K16/22 ,  C07K16/28 ,  C07K16/46 ,  C12N9/64 ,  C12N15/85

CPC classification number: C07K16/40 ,  A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2866 ,  C07K16/461 ,  C07K16/462 ,  C07K2317/21 ,  C07K2317/92 ,  C12N9/6489 ,  C12N15/8509 ,  C12N2800/204 ,  C12N2800/30

Abstract: Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.

公开(公告)号：US20180334497A1

公开(公告)日：2018-11-22

申请号：US15991662

申请日：2018-05-29

Applicant: The Regents of the University of California

Inventor： Joseph L. Witztum ,  Sotirios Tsimikas ,  Xuchu Que

IPC: C07K16/18 ,  A01K67/027 ,  A61K39/00

CPC classification number: C07K16/18 ,  A01K67/0275 ,  A01K67/0278 ,  A01K2217/052 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/0362 ,  A01K2267/0368 ,  A01K2267/0375 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/76

Abstract: The disclosure provides for single chain variable fragments to oxidized phospholipid epitopes and methods of use thereof, including the production of transgenic animal models and the use of the fragments as therapeutic agents for treating CAS.

公开(公告)号：US20180271070A1

公开(公告)日：2018-09-27

申请号：US16001070

申请日：2018-06-06

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： John McWhirter ,  Cagan Gurer ,  Lynn Macdonald ,  Andrew J. Murphy

IPC: A01K67/027 ,  G01N33/50 ,  C07K14/47 ,  C07K14/705 ,  C12N15/85

CPC classification number: A01K67/0278 ,  A01K2207/15 ,  A01K2217/052 ,  A01K2217/07 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0387 ,  C07K14/47 ,  C07K14/70575 ,  C07K2319/00 ,  C12N15/8509 ,  G01N33/5005

Abstract: Non-human animals, cells, methods and compositions for making and using the same are provided, wherein the non-human animals and cells comprise a humanized a proliferation-inducing ligand gene. Non-human animals and cells that express a human or humanized a proliferation-inducing ligand protein from an endogenous a proliferation-inducing ligand locus are described.

公开(公告)号：US20180249687A1

公开(公告)日：2018-09-06

申请号：US15753938

申请日：2016-08-24

Applicant: Crystal Bioscience Inc.

Inventor： William Don Harriman ,  Robert Etches ,  Philip A. Leighton

IPC: A01K67/027 ,  C07K16/46 ,  C12N15/85

CPC classification number: A01K67/0278 ,  A01K2217/072 ,  A01K2217/206 ,  A01K2227/30 ,  A01K2267/01 ,  C07K16/00 ,  C07K16/46 ,  C07K2317/21 ,  C07K2317/23 ,  C12N15/8509 ,  C12N2800/30 ,  C12N2830/40

Abstract: This disclosure provides, among other things, a transgenic animal and a method of using the same to make antibodies that have a common light chain. In certain embodiments, the transgenic animal may comprising a genome comprising a common light chain transgene, wherein the common light chain transgene comprises a non-immunoglobulin light-chain promoter and a common light-chain coding sequence. In certain embodiments, the common light chain is constitutively expressed.