公开(公告)号：US11149049B2

公开(公告)日：2021-10-19

申请号：US16648405

申请日：2018-09-18

申请人： JANSSEN BIOPHARMA, INC.

发明人： Leonid Beigelman ,  Jerome Deval ,  Marija Prhavc

IPC分类号： C07H7/06 ,  A61P31/14 ,  A61P31/16 ,  C07H9/04

摘要： Disclosed herein are compounds of the Formula (I) and pharmaceutically acceptable salts thereof: (I) where the variables in Formula (I) are described herein. Methods of synthesizing such compounds and methods of using them to treat diseases and/or conditions such as a Picornaviridae, Flaviviridae, Filoviridae, Pneumoviridae and/or Coronaviridae viral infections are also disclosed.

公开(公告)号：US20210186969A1

公开(公告)日：2021-06-24

申请号：US17185750

申请日：2021-02-25

申请人： Janssen BioPharma, Inc.

发明人： Robert Than HENDRICKS ,  Leonid BEIGELMAN ,  David Bernard SMITH ,  Antitsa Dimitrova STOYCHEVA

IPC分类号： A61K31/5025 ,  C07D487/04 ,  A61K31/13 ,  A61K31/196 ,  A61K31/215 ,  A61K31/351 ,  A61K31/4965 ,  A61K31/5377 ,  A61K31/7056 ,  A61K38/21 ,  C07B59/00

摘要： Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.

公开(公告)号：US11021509B2

公开(公告)日：2021-06-01

申请号：US16528414

申请日：2019-07-31

申请人： Janssen BioPharma, Inc.

发明人： Leonid Beigelman ,  Guangyi Wang ,  David Bernard Smith ,  Jerome Deval ,  Marija Prhavc

IPC分类号： C07H19/06 ,  C07H19/207 ,  C07H19/16 ,  A61P31/16 ,  A61K45/06 ,  C07D405/04 ,  C07D405/14 ,  C07D473/18 ,  C07D473/34 ,  C07D487/04 ,  C07D493/04 ,  C07H19/00 ,  C07H19/14 ,  C12N9/12 ,  C07H19/10 ,  C07H19/12 ,  C07H19/20

摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.

公开(公告)号：US11014935B2

公开(公告)日：2021-05-25

申请号：US15627757

申请日：2017-06-20

申请人： JANSSEN BIOPHARMA, INC.

发明人： Guangyi Wang ,  Leonid Beigelman ,  Anh Truong ,  Carmela Napolitano ,  Daniele Andreotti ,  Haiying He

IPC分类号： C07D409/04 ,  C07D495/04 ,  C07D333/58 ,  C07D215/12 ,  C07D215/14 ,  C07D311/68 ,  C07D215/42 ,  C07D217/24 ,  C07D333/16 ,  C07D333/20 ,  C07D233/38 ,  C07D333/50 ,  C07D333/54 ,  C07D233/61 ,  C07D333/62 ,  C07D333/66 ,  C07D333/68 ,  C07D335/06 ,  C07D233/88 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D261/20 ,  C07D207/335 ,  C07D209/08 ,  C07D209/14 ,  C07D277/64 ,  C07D209/86 ,  C07D213/42 ,  C07D213/50 ,  C07D213/65 ,  C07D213/68 ,  C07D307/52 ,  C07D307/81 ,  C07D233/60 ,  C07D495/14 ,  C07C251/84 ,  A61K45/06 ,  A61K31/381 ,  A61K31/404 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  C07C243/34 ,  C07C251/80 ,  C07C255/34 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4436 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5377 ,  C07D209/20 ,  C07D233/64 ,  C07D277/56 ,  C07D409/06 ,  C07D409/12 ,  A61K31/165 ,  A61K31/277 ,  A61K31/341 ,  A61K31/343 ,  A61K31/352 ,  A61K31/382 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/4196 ,  A61K31/423 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4365 ,  A61K31/4375 ,  A61K31/4427 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/538 ,  C07C243/18 ,  C07C255/66 ,  C07D215/38 ,  C07D307/40 ,  C07D307/91 ,  C07D333/76 ,  C07D405/10 ,  C07D413/14

摘要： Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

公开(公告)号：US20210040483A1

公开(公告)日：2021-02-11

申请号：US17063080

申请日：2020-10-05

申请人： Janssen Biopharma, Inc.

发明人： Sergei GRYAZNOV ,  Leonid BEIGELMAN ,  Antitsa Dimitrova STOYCHEVA ,  Saul MARTINEZ MONTERO ,  Jin HONG ,  Rajendra K. PANDEY ,  Vivek Kumar RAJWANSHI ,  Lakshmipathi PANDARINATHAN ,  Yi JIN ,  Bharat BARAL

IPC分类号： C12N15/113 ,  A61K31/7125 ,  A61P31/20 ,  A61K31/712 ,  C07H21/02 ,  A61K47/54 ,  C12N15/11

摘要： Modified oligonucleotides comprising modifications at the 2′ and/or 3′ position(s) along with methods of making and use, e.g., against HBV are disclosed.

公开(公告)号：US10793591B2

公开(公告)日：2020-10-06

申请号：US16692858

申请日：2019-11-22

申请人： Janssen BioPharma, Inc.

发明人： Leonid Beigelman ,  Guangyi Wang ,  David Bernard Smith

IPC分类号： C07H19/073 ,  C07H19/173 ,  C07H19/20 ,  C07H19/207 ,  C07H19/10 ,  C07H19/06 ,  C07H19/213 ,  A61P31/14 ,  C07H19/16

摘要： Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.

公开(公告)号：US10780105B2

公开(公告)日：2020-09-22

申请号：US16105859

申请日：2018-08-20

申请人： Janssen BioPharma, Inc.

发明人： Lawrence M. Blatt ,  Leonid Beigelman ,  Natalia Dyatkina ,  Julian Alexander Symons ,  David Bernard Smith

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K31/7068 ,  A61K31/708 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064

摘要： Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.