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公开(公告)号：US12007370B2
公开(公告)日：2024-06-11
申请号：US17347807
申请日：2021-06-15
CPC分类号： G01N30/30 , G01N2030/025 , G01N2030/027 , G01N2030/3015 , G01N2030/3046
摘要： Exemplary embodiments may compensate for expected frictional heating or Joule-Thomson cooling in chromatography columns. Frictional heating or Joule Thomson cooling are the same thing for a fluid decompressing along a porous material. Either heat is absorbed from or released to the external environment. The exemplary embodiments may cool the mobile phase to a sub-ambient temperature before the mobile phase passes through a chromatography column to compensate for the frictional heating or heat the mobile phase to a super-ambient temperature to compensate for Joule-Thomson cooling. The amount of temperature increase expected from the frictional heating or the amount of temperature decrease expected from the Joule-Thomson cooling may be calculated or estimated. Based on the amount of temperature increase or decrease expected, the set point for the heater/cooler may be determined and applied to the mobile phase. The analyte may be injected solely into a central portion of the chromatography column to further compensate for thermal gradients.
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公开(公告)号：US11994500B2
公开(公告)日：2024-05-28
申请号：US17084998
申请日：2020-10-30
发明人： Mark J. Basile , Jeffrey Musacchio , Michael O. Fogwill , Sebastien Besner , Joseph D. Michienzi , Wade P. Leveille
CPC分类号： G01N30/74 , G01N30/30 , G01N2030/027 , G01N2030/3038 , G01N2030/746
摘要： Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described. In one embodiment, for example, a column-optical cell assembly may include an insulating device, a chromatography column arranged within the insulating device, and an optical flow cell in fluid communication with the chromatography column, the chromatography column arranged within a minimum distance of the optical flow cell.
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公开(公告)号：US11821530B2
公开(公告)日：2023-11-21
申请号：US17569744
申请日：2022-01-06
CPC分类号： F16K15/1843 , F16K31/0665
摘要： Described is an active check valve that uses electro-magnetic actuation for operation. The valve includes a plunger assembly having a magnet in a sealed internal volume. The plunger assembly further includes a plunger tip that extends from either a plunger assembly housing or a sealing member. Although the plunger assembly is disposed in the solvent flow, the magnet is not exposed to the solvent. When the valve is actuated, the plunger tip moves the sealing member to open or close the valve. Optionally, an arming force may be applied to the sealing member in advance of opening or closing to reduce the subsequent additional force necessary to move the sealing member during opening or closing, thereby improving the accuracy of the solvent composition in liquid chromatography system applications.
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公开(公告)号：US11511213B2
公开(公告)日：2022-11-29
申请号：US15752121
申请日：2016-08-12
发明人： Jonathan L. Belanger , Hua Yang , Edouard S. P. Bouvier , Mathew DeLano , Raymond P. Fisk , Hillary B. Hewitson , Wade P. Leveille , Kevin Daniel Wyndham
摘要： Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.
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公开(公告)号：US20220128526A1
公开(公告)日：2022-04-28
申请号：US17513003
申请日：2021-10-28
发明人： Wade P. Leveille , Sylvain G. Cormier , Michael O. Fogwill , Joseph D. Michienzi , Jeffrey Musacchio , Joseph D. Antocci
摘要： Exemplary embodiments integrate a tee or valve into an outlet end fitting of a liquid chromatography column. The tee or valve is suitable for providing additional fluidic flow paths to ports of the end fitting and eliminates the need for post-column fluidic conduits connecting to tees or valves to insert fluidic inputs or divert flow to outputs. This integration decreases the distance that eluent from the liquid chromatography column has to travel to reach a detector relative to systems that use external tees or valves while providing tee/valve functionality and reducing the fluidic volume post-column. As a result, the exemplary embodiments help decrease sample dispersion.
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公开(公告)号：US11185795B2
公开(公告)日：2021-11-30
申请号：US15487599
申请日：2017-04-14
发明人： Edouard S. P. Bouvier , Joseph A. Jarrell , Wade P. Leveille , Fabrice Gilles Ernest Gritti , Theodore A. Dourdeville , Michael O. Fogwill
摘要： Apparatus and methods for performing chromatography may include a chromatography column and a vacuum insulated jacket having an inner wall and an outer wall. A vacuum area may be formed between the inner wall and the outer wall. The inner wall of the vacuum insulated jacket may surround the chromatography column. A gap may be formed between an outer wall of the chromatography column and the inner wall of the vacuum insulated jacket. The vacuum insulated jacket may extend beyond one or more end frits of the column. The gap may be filled with one or more materials so as to form an insulating or thermal barrier.
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公开(公告)号：US11169125B2
公开(公告)日：2021-11-09
申请号：US16384272
申请日：2019-04-15
发明人： Michael O. Fogwill , Curt Devlin , Theodore A. Dourdeville , Jacob N. Fairchild , Geoff C. Gerhardt , Wade P. Leveille , Joseph D. Michienzi , Jeffrey Musacchio
摘要： Techniques and apparatus for ion source devices with minimized post-column volumes are described. In one embodiment, for example, an ion source assembly may include a chromatography column in fluid communication with an ion source device, the chromatography column arranged within a minimum distance of the ion source, the minimum distance comprising between about 60 mm and about 150 mm.
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公开(公告)号：US11125729B2
公开(公告)日：2021-09-21
申请号：US16223330
申请日：2018-12-18
摘要： In various aspects provided are purification media and containers for dispensing a purified liquid are provided herein where a high surface area-to-volume chemically interactive purification media positioned at the outlet of a container that purifies the liquid as it is dispensed and/or extracted.
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公开(公告)号：US20210132012A1
公开(公告)日：2021-05-06
申请号：US17084998
申请日：2020-10-30
发明人： Mark J. Basile , Jeffrey Musacchio , Michael O. Fogwill , Sebastien Besner , Joseph D. Michienzi , Wade P. Leveille
摘要： Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described. In one embodiment, for example, a column-optical cell assembly may include an insulating device, a chromatography column arranged within the insulating device, and an optical flow cell in fluid communication with the chromatography column, the chromatography column arranged within a minimum distance of the optical flow cell.
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公开(公告)号：US20190317062A1
公开(公告)日：2019-10-17
申请号：US16384272
申请日：2019-04-15
发明人： Michael O. Fogwill , Curt Devlin , Theodore A. Dourdeville , Jacob N. Fairchild , Geoff C. Gerhardt , Wade P. Leveille , Joseph D. Michienzi , Jeffrey Musacchio
IPC分类号： G01N30/72
摘要： Techniques and apparatus for ion source devices with minimized post-column volumes are described. In one embodiment, for example, an ion source assembly may include a chromatography column in fluid communication with an ion source device, the chromatography column arranged within a minimum distance of the ion source, the minimum distance comprising between about 60 mm and about 150 mm.
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