公开(公告)号：US20230186532A1

公开(公告)日：2023-06-15

申请号：US17923617

申请日：2021-04-21

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Christophe Michael Jean Schuelke ,  Karsten Sommer ,  George Randall Duensing ,  Peter Boernert

IPC: G06T11/00 ,  G01R33/56 ,  G01R33/565 ,  G01R33/54

CPC classification number: G06T11/005 ,  G01R33/5608 ,  G01R33/565 ,  G01R33/543 ,  G06T11/006 ,  G06T2211/424

Abstract: Disclosed herein is a medical system (100, 300) comprising a memory (110) storing machine executable instructions (120) and an image generating neural network (122). The image generating neural network is configured for outputting synthetic magnetic resonance image data (128) in response to receiving reference magnetic resonance image data (126) as input. The synthetic magnetic resonance image data is a simulation of magnetic resonance image data acquired according to a first configuration of a magnetic resonance imaging system when the reference magnetic resonance image data is acquired according to a second configuration of the magnetic resonance imaging system. Execution of the machine executable instructions causes a computational system (106) to: receive (200) measured k-space data (124) acquired according to the first configuration of the magnetic resonance imaging system; receive (202) the reference magnetic resonance image data; receive (204) the synthetic magnetic resonance image data by inputting the reference magnetic resonance image data into the image generating neural network; and reconstruct (206) corrected magnetic resonance image data (132) from the measured k-space data and the synthetic magnetic resonance image data.

公开(公告)号：US20230145981A1

公开(公告)日：2023-05-11

申请号：US17918582

申请日：2021-04-20

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Kay Nehrke ,  Peter Boernert

IPC: G01R33/24 ,  G01R33/56 ,  G01R33/50 ,  G01R33/561

CPC classification number: G01R33/246 ,  G01R33/5602 ,  G01R33/50 ,  G01R33/5617

Abstract: The invention relates to a method of MR imaging. It is an object of the invention to provide an improved B1 mapping method that is less affected by T1 relaxation. The invention proposes that a first stimulated echo imaging sequence (25) is generated comprising at least two preparation RF pulses (α) radiated during a first preparation period (21) and a sequence of reading RF pulses (β) radiated during a first acquisition period (22) temporally subsequent to the first preparation period (21). A first set of FID signals (IFID) and a first set of stimulated echo signals (ISTE) are acquired during the first acquisition period (22). A second stimulated echo imaging sequence (27) is generated comprising again at least two preparation RF pulses (α) radiated during a second preparation period (21) and a sequence of reading RF pulses (β) radiated during a second acquisition period (22) temporally subsequent to the second preparation period (21). A second set of FID signals (IFID) and a second set of stimulated echo signals (ISTE) are acquired during the second acquisition period (22). The first and second sets of FID signals (IFID) have different T1-weightings and/or the first and second sets of stimulated echo signals (ISTE) have different T1-weightings. A B1 map indicating the spatial distribution of the RF field of the RF pulses is derived from the acquired first and second sets of FID (IFID) and stimulated echo (ISTE) signals, wherein the different T1-weightings are made use of to compensate for influences on the B1 map caused by T1 relaxation. Preferably, either the first or the second preparation period (21) is preceded by an RF inversion pulse to obtain the different T1-weightings. Moreover, the invention relates to an MR device (1) and to a computer program for an MR device (1).

公开(公告)号：US10794979B2

公开(公告)日：2020-10-06

申请号：US15780658

申请日：2016-11-08

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Peter Boernert ,  Miha Fuderer ,  Ivan Dimitrov

IPC: G01R33/561 ,  G01R33/565

Abstract: The invention provides for a magnetic resonance imaging system (100, 300) comprising: a radio-frequency system (116, 122, 124, 126, 126′, 126″, 126′″) for acquiring magnetic resonance data (152) from an imaging zone (108), wherein the radio-frequency system comprises multiple antenna elements (126, 126′, 126″, 126′″); a memory (140) containing machine executable instructions (170) and pulse sequence commands (150), wherein the pulse sequence commands cause the processor to acquire magnetic resonance data from the multiple antenna elements according to a SENSE protocol; and a processor. Execution of the machine executable instructions causes the processor to: control (200) the magnetic resonance imaging system with the pulse sequence commands to acquire the magnetic resonance data; reconstruct (202) a preliminary image (154) using the magnetic resonance imaging data; calculate (204) a fit (159) between an anatomical model (156) and the preliminary image, wherein the anatomical model comprises a motion likelihood map (158); identify (206) at least one image artifact origin (160) at least partially using the motion likelihood map and the fit; determine (208) an extended SENSE equation (162) at least partially using at least one image artifact origin; and construct (210) a corrected SENSE image (164) using the extended SENSE equation.

公开(公告)号：US10794976B2

公开(公告)日：2020-10-06

申请号：US15527028

申请日：2015-11-16

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Thomas Erik Amthor ,  Sascha Krueger ,  Mariya Ivanova Donevea ,  Peter Koken ,  Julien Senegas ,  Jochen Keupp ,  Peter Boernert

IPC: A61B5/00 ,  A61B5/055 ,  G01R33/56 ,  G16H50/70 ,  G16H50/20 ,  G01R33/48 ,  G06F21/32 ,  G01R33/50 ,  G06K9/62

Abstract: A method of employing a central computer database (18) for supporting a characterization of tissue by magnetic resonance fingerprinting measurements, includes: exciting nuclei of a subject of interest by applying (50) a radio frequency excitation field B1 generated according to a magnetic resonance fingerprinting sequence (38), acquiring (52) magnetic resonance imaging signal data from radiation emitted by excited nuclei of the subject of interest, transferring (54) a magnetic resonance fingerprinting data set (42) to the central computer database (18), retrieving (56) a predefined dictionary from the central computer database (18), matching (60) the acquired magnetic resonance imaging signal data to the retrieved dictionary by applying a pattern recognition algorithm to determine a value (40) or a set of values (40) for at least one physical quantity (T1, T2), adding (62) at least the determined value (40) or the determined set of values (40) as a new entry of an associated medical data set (36) to the central computer database (18), and making (64) the new entry of an associated medical data set (36) accessible to users of the central computer database (18). A magnetic resonance fingerprinting data collection and analysis system (10) includes a central computer database, a data receiving unit (20), a data output unit (22) and a data analysis device (26) configured to carry out the method.

公开(公告)号：US10591565B2

公开(公告)日：2020-03-17

申请号：US15572182

申请日：2016-04-28

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Kay Nehrke ,  Peter Boernert

IPC: G01R33/561 ,  G01R33/24 ,  G01R33/56

Abstract: The invention relates to a method of MR imaging of an object (10). The problem of the invention is to provide an improved MR imaging technique that enables fast and robust determination of spatial sensitivity profiles of RF receiving antennas (11, 12, 13) used in parallel imaging as well as B1 and/or B0 mapping. The method of the invention comprises subjecting the object (10) to a stimulated echo sequence. Two or more stimulated echo signals (STE, STE*) are acquired, namely a direct stimulated echo signal (STE) and a conjugated stimulated echo signal (STE*), wherein at least one of the stimulated echo signals (STE, STE*) is received in parallel via an array of two or more RF receiving antennas (11, 12, 13) having different spatial sensitivity profiles, and wherein at least another one of the stimulated echo signals (STE, STE*) is received via a body RF coil (9) having an essentially homogeneous spatial sensitivity profile. Sensitivity maps indicating the spatial sensitivity profiles of the individual RF receiving antennas (11, 12, 13) of the array are derived by comparing the stimulated echo signals (STE, STE*) received via the array of RF receiving antennas (11, 12, 13) with the stimulated echo signals (STE, STE*) received via the body RF coil (9). Moreover, the invention relates to a MR device (1) and to a computer program for a MR device (1).

公开(公告)号：US10591562B2

公开(公告)日：2020-03-17

申请号：US15735314

申请日：2016-06-07

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Peter Boernert ,  Kay Nehrke ,  Holger Eggers

IPC: G01R33/00 ,  G01R33/48 ,  G01R33/44 ,  G01R33/565 ,  A61B5/055 ,  G01R33/56 ,  A61N5/10

Abstract: The invention provides for a medical instrument (100, 500) comprising a magnetic resonance imaging system (102) for acquiring magnetic resonance data (142) from a subject (118) within an imaging zone (108). The magnetic resonance imaging system comprises: a main magnet (104) for generating a B0 magnetic field within the imaging zone; a memory (134, 136) containing machine executable instructions (160, 162, 164, 166) and pulse sequence commands (140); a processor (130) for controlling the medical instrument. Execution of the machine executable instructions causes the processor to: acquire (200) the magnetic resonance data by controlling the magnetic resonance imaging system with the pulse sequence commands; receive (202) a subject magnetic susceptibility map (144) of the subject; calculate (204) a B0 inhomogeneity map (146) from the magnetic resonance data; calculate (206) a subject B0 magnetic field perturbation (148) from the subject magnetic susceptibility map; calculate (208) a residual B0 magnetic field perturbation (150) by subtracting the subject B0 magnetic field perturbation from the B0 inhomogeneity map; and calculate (210) a bone map (152) from the residual B0 magnetic field perturbation.

公开(公告)号：US10539640B2

公开(公告)日：2020-01-21

申请号：US15521643

申请日：2015-10-30

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Radu Serban Jasinschi ,  Rudolf Mathias Johannes Nicolaas Lamerichs ,  Peter Boernert

IPC: G01R33/56 ,  G01R33/44 ,  A61B5/055 ,  G01R33/561

Abstract: A magnetic resonance imaging protocol includes an acquisition segment to control an acquisition sequence to acquire magnetic resonance signals at a lower main magnetic field strength. A reconstruction segment controls reconstruction of a diagnostic magnetic resonance image from the magnetic resonance signals at a lower main magnetic field strength. A segmentation segment controls segmentation of a predetermined image detail of the diagnostic magnetic resonance image. In the magnetic resonance imaging protocol, the acquisition sequence has a set of imaging parameters that cause the image quality of the diagnostic magnetic resonance to be similar to the image quality of the magnetic resonance training images, e.g., acquired at 7 T. The segmentation segment includes an initialization portion which controls (i) access to a set of magnetic resonance training images acquired at main magnetic field of a higher main magnetic field strength (ii) registration of the diagnostic magnetic resonance image to one or more of the magnetic resonance training images and (iii) a segmentation proper applied to the diagnostic image to segment the predetermined detail from the registered diagnostic magnetic resonance image.

公开(公告)号：US10345407B2

公开(公告)日：2019-07-09

申请号：US15547622

申请日：2016-01-22

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Peter Boernert ,  Mariya Ivanova Doneva ,  Thomas Erik Amthor ,  Peter Koken ,  Jochen Keupp

IPC: G01R33/46 ,  G01R33/54 ,  G01R33/58 ,  G16H40/40 ,  G01R33/48

Abstract: The invention provides for a method of operating a magnetic resonance system for acquiring magnetic resonance data (152) from a phantom (124) within a measurement (zone 108). The phantom comprises a known volume of at least one predetermined substance ((128), 130). The method comprises the step of acquiring (300) the magnetic resonance data by controlling the magnetic resonance system with pulse sequence instructions (150). The pulse sequence instructions cause the magnetic resonance system to acquire the magnetic resonance data according to a magnetic resonance fingerprinting technique. The pulse sequence instructions specify a train of pulse sequence repetitions. Each pulse sequence repetition has a repetition time chosen from a distribution of repetition times. Each pulse sequence repetition comprises a radio frequency pulse chosen from a distribution of radio frequency pulses. The distribution of radio frequency pulses cause magnetic spins to rotate to a distribution of flip angles. Each pulse sequence repetition comprises a sampling event where the magnetic resonance signal is sampled for a predetermined duration at a sampling time before the end of the pulse sequence repetition. The method further comprises determining (302) one or more performance degradation conditions of the magnetic resonance system by comparing the magnetic resonance data with a magnetic resonance fingerprinting dictionary (154). The magnetic resonance fingerprinting dictionary contains a listing of magnetic resonance signals for a set of system states in response to execution of the pulse sequence instructions for each of the at least one predetermined substance.

公开(公告)号：US10321845B2

公开(公告)日：2019-06-18

申请号：US15525145

申请日：2015-10-30

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Thomas Erik Amthor ,  Mariya Ivanova Doneva ,  Peter Koken ,  Jochen Keupp ,  Peter Boernert

IPC: G01V3/00 ,  A61B5/055 ,  G01R33/30 ,  G01R33/48 ,  G01R33/483 ,  G01R33/50 ,  G01R33/54 ,  A61B5/00 ,  G01R33/563

Abstract: The invention provides for a magnetic resonance imaging system (100) which comprise a magnet (104) and a magnetic field gradient generator (110, 112) for generating a gradient magnetic field within an imaging zone (108). The gradient magnetic field is aligned with a predetermined direction. The magnetic resonance imaging system further comprise a memory (134, 136) for storing machine executable instructions (150, 152, 154), a pre-calculated magnetic resonance fingerprinting dictionary (144), and pulse sequence instructions (140). The pulse sequence instructions cause the magnetic resonance imaging system to acquire the magnetic resonance data according to a magnetic resonance fingerprinting technique. The magnetic resonance fingerprinting technique encodes the magnetic resonance data as slices (125). The pre-calculated magnetic resonance fingerprinting dictionary contains a listing of calculated magnetic resonance signals in response to execution of the pulse sequence instructions for a set of predetermined substances. Execution of the machine executable instructions causes a processor (130) controlling the magnetic resonance imaging system to: acquire (300) the magnetic resonance data by controlling the magnetic resonance imaging system with pulse sequence instructions; divide (302) the magnetic resonance data into a set of slices; calculate (304) the abundance of each of the set of predetermined substances within each of the set of slices by comparing the magnetic resonance data for each of the set of slices with the pre-calculated magnetic resonance fingerprinting dictionary; and calculate (306) a magnetic resonance fingerprint chart by plotting abundance of each of the set of predetermined substances within each of the set of slices as a function of position along the predetermined direction.

公开(公告)号：US09511244B2

公开(公告)日：2016-12-06

申请号：US14881472

申请日：2015-10-13

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Tim Nielsen ,  Peter Boernert ,  Falk Uhlemann ,  Johannes Adrianus Overweg

IPC: A61B6/00 ,  A61N5/10 ,  G01R33/381 ,  G01R33/48 ,  G01R33/38 ,  G01R33/56

CPC classification number: A61N5/1071 ,  A61N5/1031 ,  A61N5/1039 ,  A61N5/1049 ,  A61N2005/1055 ,  A61N2005/1058 ,  G01R33/3806 ,  G01R33/381 ,  G01R33/4808 ,  G01R33/5601

Abstract: A combined magnetic resonance (MR) and radiation therapy system includes a bore-type magnet with a magnet radiation translucent region which allows radiation beams to travel radially through the magnet and a split-type gradient coil includes a gradient coil radiation translucent region aligned to the magnet radiation translucent region. A radiation source, disposed laterally to the magnet, administers a radiation dose through the magnet and gradient coil radiation translucent regions to an examination region. A dosage unit determines the actual radiation dose delivered to each voxel of a target volume and at least one non-target volume based on a pre-treatment, intra-treatment, and/or post-treatment image representation of the target volume and the at least one non-target volume. A planning processor updates at least one remaining radiation dose of a radiation therapy plan based on the determined actual radiation dose.

Abstract translation: 组合磁共振（MR）和放射治疗系统包括具有磁体辐射半透明区域的孔型磁体，其允许辐射束径向穿过磁体，并且分离式梯度线圈包括梯度线圈辐射半透明区域 磁体辐射半透明区域。 辐射源横向设置在磁体上，通过磁体和梯度线圈辐射半透明区域将辐射剂量施加到检查区域。 剂量单位基于目标体积的预处理，治疗前和/或后处理图像表示来确定递送到目标体积的每个体素的实际辐射剂量和至少一个非目标体积， 至少一个非目标卷。 计划处理器基于所确定的实际辐射剂量来更新辐射治疗计划的至少一个剩余辐射剂量。