公开(公告)号：US11084877B2

公开(公告)日：2021-08-10

申请号：US16250398

申请日：2019-01-17

Applicant: Genentech, Inc.

Inventor： Bing Zheng ,  Andrew Polson ,  Cecilia Chiu ,  Wei-Ching Liang ,  Yan Wu

IPC: A61K39/00 ,  C07K16/28 ,  A61K47/68 ,  A61K31/5517 ,  A61K31/706 ,  A61K51/10 ,  C07K16/30 ,  G01N33/574

Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20200148774A1

公开(公告)日：2020-05-14

申请号：US16658706

申请日：2019-10-21

Applicant: Genentech, Inc.

Inventor： Robert F. Kelley ,  Steven R. Leong ,  Wei-Ching Liang ,  Mary Mathieu ,  Andrew G. Polson ,  Bing Zheng ,  Xiaocheng Chen ,  Cecilia Pui Chi Chiu ,  Mark S. Dennis ,  Allen Ebens ,  Yan Wu

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06

Abstract: The present invention relates to anti-CLL-1 antibodies including anti-CLL-1 antibodies comprising a CLL-1 binding domain and a CD3 binding domain (e.g., anti-CLL-1/CD3 T cell dependent bispecific (TDB) antibody) and methods of using the same.

公开(公告)号：US10421821B2

公开(公告)日：2019-09-24

申请号：US15336171

申请日：2016-10-27

Applicant: Genentech, Inc.

Inventor： Robert F. Kelley ,  Daniel K. Kirchhofer ,  Joyce Lai ,  Chingwei V. Lee ,  Wei-Ching Liang ,  Michael T. Lipari ,  Kelly M. Loyet ,  Tao Sai ,  Menno Van Lookeren Campagne ,  Yan Wu ,  Germaine Fuh

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/40

Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

公开(公告)号：US10287356B2

公开(公告)日：2019-05-14

申请号：US15356483

申请日：2016-11-18

Applicant: GENENTECH, INC.

Inventor： Avi Ashkenazi ,  Jing Qing ,  Christian Wiesmann ,  Yan Wu

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K39/00

Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.

公开(公告)号：US10239947B2

公开(公告)日：2019-03-26

申请号：US15657471

申请日：2017-07-24

Applicant: Genentech, Inc.

Inventor： Bing Zheng ,  Andrew Polson ,  Cecilia Chiu ,  Wei-Ching Liang ,  Yan Wu

IPC: A61K39/395 ,  C07K16/28 ,  A61K31/5517 ,  A61K31/706 ,  A61K51/10 ,  C07K16/30 ,  G01N33/574 ,  A61K47/68

Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US10227412B2

公开(公告)日：2019-03-12

申请号：US15657476

申请日：2017-07-24

Applicant: Genentech, Inc.

Inventor： Bing Zheng ,  Andrew Polson ,  Cecilia Chiu ,  Wei-Ching Liang ,  Yan Wu

IPC: G01N33/574 ,  C07K16/28 ,  A61K31/5517 ,  A61K31/706 ,  A61K51/10 ,  C07K16/30 ,  A61K47/68

Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20190048097A1

公开(公告)日：2019-02-14

申请号：US16168503

申请日：2018-10-23

Applicant: Genentech, Inc.

Inventor： Robert F. Kelley ,  Daniel K. Kirchhofer ,  Joyce Lai ,  Chingwei V. Lee ,  Wei-Ching Liang ,  Michael T. Lipari ,  Kelly M. Loyet ,  Tao Sai ,  Menno Van Lookeren Campagne ,  Yan Wu ,  Germaine Fuh

IPC: C07K16/40 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

公开(公告)号：US20180312579A1

公开(公告)日：2018-11-01

申请号：US15837647

申请日：2017-12-11

Applicant: Genentech, Inc,

Inventor： Elaine Storm ,  Frederic J. de Sauvage ,  Jeremy M. Murray ,  Cameron L. Noland ,  Yan Wu ,  Christine Tan ,  Jo-Anne Hongo ,  Yongmei Chen

IPC: C07K16/18 ,  A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6843 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/3046 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are anti-RSPO antibodies, in particular anti-RSPO2 antibodies and/or anti-RSPO3 antibodies, and methods of using the same.

公开(公告)号：US10113002B2

公开(公告)日：2018-10-30

申请号：US14421103

申请日：2013-08-13

Applicant: Genentech, Inc.

Inventor： Christian W. Siebel ,  Yan Wu

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  A61K47/48 ,  C07K16/24 ,  C07K14/475 ,  C07K14/52 ,  A61K39/00 ,  C07K16/30

Abstract: The disclosure provides anti-Jagged antibodies and methods of using the same.

公开(公告)号：US10059768B2

公开(公告)日：2018-08-28

申请号：US14851003

申请日：2015-09-11

Applicant: Genentech, Inc.

Inventor： Steven R. Leong ,  Andrew Polson ,  Paul Polakis ,  Yan Wu ,  Wei-Ching Liang ,  Ron Firestein

IPC: C07K16/28 ,  C07K16/30 ,  A61K31/404 ,  A61K31/5517 ,  A61K31/706 ,  A61K38/05 ,  G01N33/574 ,  A61K47/68

CPC classification number: C07K16/2827 ,  A61K31/404 ,  A61K31/5517 ,  A61K31/706 ,  A61K38/05 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6855 ,  A61K47/6869 ,  A61K2039/505 ,  C07K16/3015 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57492

Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.