公开(公告)号：US20180028313A1

公开(公告)日：2018-02-01

申请号：US15729986

申请日：2017-10-11

Applicant: Edwards Lifesciences Corporation

Inventor： Stanton J. Rowe ,  Francesco Maisano ,  Oded Meiri

IPC: A61F2/24 ,  A61M25/00 ,  A61M25/10 ,  A61B17/04 ,  A61B17/32

Abstract: Prosthetic valve systems for replacing a native valve exhibiting regurgitation comprises a support structure and a transcatheter heart valve (THV) that is separate from the support structure. The support structure can be configured to be positioned such that it extends annularly around the native valve leaflets. After the support structure is deployed around the native valve leaflets, the THV can be expanded within the support structure such that the native valve leaflets are engaged between the support structure and the THV.

公开(公告)号：US09561101B2

公开(公告)日：2017-02-07

申请号：US14091239

申请日：2013-11-26

Applicant: Edwards Lifesciences Corporation

Inventor： Stanton J. Rowe ,  Francesco Maisano ,  Oded Meiri

IPC: A61F2/24 ,  A61B17/04 ,  A61B17/32 ,  A61M25/10 ,  A61M25/00

CPC classification number: A61F2/2427 ,  A61B17/0467 ,  A61B2017/32004 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2445 ,  A61F2220/0016 ,  A61F2230/0054 ,  A61F2250/006 ,  A61F2310/00023 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/0004

Abstract: A prosthetic valve system for replacing a native aortic valve exhibiting regurgitation may include a support structure and a transcatheter heart valve (THV) that is separate from the support structure. The support structure may be radially collapsible and expandable, and deployable on an outflow side of the native aortic valve, circumscribing the native leaflets of the aortic valve. The THV may be radially collapsible and expandable, and deployable in an annulus of the native aortic valve to frictionally engage the native leaflets between an interior surface of the support structure and the THV.

Abstract translation: 用于替代显示反流的天然主动脉瓣的人工瓣膜系统可以包括与支撑结构分离的支撑结构和经导管心脏瓣膜（THV）。 支撑结构可以是径向可折叠和可扩张的，并且可部署在天然主动脉瓣的流出侧，限定主动脉瓣的天然传播。 THV可以是径向可折叠和可扩张的，并且可部署在天然主动脉瓣的环形空间中以摩擦地接合支撑结构的内表面和THV之间的天然小叶。

公开(公告)号：US20140343671A1

公开(公告)日：2014-11-20

申请号：US14451264

申请日：2014-08-04

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0065 ,  A61F2250/0069

Abstract: The present disclosure is directed to embodiments of catheter-based prosthetic heart valves, and in particular, prosthetic heart valves having sealing devices configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. In one embodiment, a prosthetic heart valve includes an annular sealing member that can be placed in a delivery orientation extending axially away from one end of the valve when the valve is in a radially compressed state. When the valve is expanded, the expansion of the frame causes the sealing member to be pulled to an operative orientation covering a portion of the frame. The present disclosure also discloses new mechanisms and techniques for mounting valve leaflets to a frame of a prosthetic heart valve.

Abstract translation: 本公开涉及基于导管的假体心脏瓣膜的具体实施方式，特别地，具有密封装置的假体心脏瓣膜被配置为密封假体瓣膜和植入人造瓣膜的天然环带的周围组织之间的界面。 在一个实施例中，假体心脏瓣膜包括环形密封构件，当阀处于径向压缩状态时，环形密封构件能够沿轴向远离阀的一端延伸的排放方向放置。 当阀膨胀时，框架的膨胀使得密封构件被拉到覆盖框架的一部分的操作取向。 本公开还公开了将瓣膜瓣安装到假体心脏瓣膜的框架的新机构和技术。

公开(公告)号：US12090049B2

公开(公告)日：2024-09-17

申请号：US17220818

申请日：2021-04-01

Applicant: Edwards Lifesciences Corporation

Inventor： Stanton J. Rowe ,  Francesco Maisano ,  Oded Meiri

IPC: A61F2/24 ,  A61B17/04 ,  A61B17/32 ,  A61M25/00 ,  A61M25/10

CPC classification number: A61F2/2427 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2445 ,  A61B17/0467 ,  A61B2017/32004 ,  A61F2220/0016 ,  A61F2230/0054 ,  A61F2250/006 ,  A61F2310/00023 ,  A61M2025/0004 ,  A61M25/10 ,  A61M25/104

Abstract: Prosthetic valve systems for treating a native valve exhibiting regurgitation can include a support structure in which a separate prosthetic heart valve can be placed. A method for implant a prosthetic valve system can include advancing a first catheter delivery sheath through an introducer sheath and into a left ventricle of a patient's heart, deploying at least a portion of a support structure from the first catheter delivery sheath and positioning the support structure around native leaflets of the patient's native mitral valve, positioning a prosthetic heart valve in a radially collapsed configuration within the patient's native mitral valve, and expanding the prosthetic heart valve from the radially collapsed configuration to a radially expanded configuration, wherein the prosthetic heart valve contacts the native leaflets from within the patient's native mitral valve and is separated from the support structure by the native leaflets.

公开(公告)号：US11957582B2

公开(公告)日：2024-04-16

申请号：US17468414

申请日：2021-09-07

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2/9517 ,  A61F2/9522 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/001 ,  A61F2230/0054 ,  A61F2230/0076 ,  A61F2250/0039

Abstract: A delivery assembly includes a prosthetic device, a catheter shaft, a release wire, a first line, and a second line. The prosthetic device has a first arm and a second arm. The release wire extends through the catheter shaft. The first line includes a first loop. The first line extends from the catheter shaft, through the first arm of the prosthetic device, and to the release wire, where the release wire extends through the first loop. The second line includes a second loop. The second line extends from the catheter shaft, through the second arm of the prosthetic device, and to the release wire, where the release wire extends through the second loop.

公开(公告)号：US20240016602A1

公开(公告)日：2024-01-18

申请号：US18476908

申请日：2023-09-28

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Oded Meiri ,  Tamir S. Levi ,  Ofir Witzman

IPC: A61F2/24 ,  A61B17/04 ,  A61B17/12 ,  A61B17/122 ,  A61B17/128

CPC classification number: A61F2/2409 ,  A61B17/0487 ,  A61B17/12013 ,  A61B17/122 ,  A61B17/1227 ,  A61B17/1285 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2427 ,  A61B2017/0488 ,  A61F2250/006 ,  A61F2220/0016 ,  A61F2230/0054 ,  A61F2220/0075

Abstract: A method of treating a deficient native mitral valve of a heart of a patient includes advancing a steerable, first catheter through the patient's vasculature, advancing the distal end portion of the first catheter into the heart to position the distal end portion of the first catheter adjacent the native mitral valve, adjusting the curvature of the distal end portion of the first catheter to form a first curve, advancing a distal end portion of a second catheter from a distal end of the first catheter, wherein the distal end portion of the second catheter is pre-shaped to form a second curve when advanced from the first catheter, and deploying a wire from the second catheter such that the wire extends around native leaflets of the native mitral valve.

公开(公告)号：US20230293297A1

公开(公告)日：2023-09-21

申请号：US18203119

申请日：2023-05-30

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2002/9528

Abstract: Delivery assemblies including a prosthetic heart valve and a delivery apparatus are disclosed. The prosthetic heart valve includes a frame having posts extending from a terminal outflow end of the frame and a valve structure disposed within the frame. The delivery apparatus includes an inner shaft including a valve connection portion having recesses configured to receive the posts of the frame of the prosthetic heart valve, an outer shaft including a valve sheath for retaining the prosthetic valve in a radially compressed state and retaining the posts within the recesses, and a handle including a control knob for moving the valve sheath proximally and distally relative to the handle. The control knob is seated within the handle housing such that the housing partially covers a circumferentially extending outer surface of the control knob.

公开(公告)号：US20230172714A1

公开(公告)日：2023-06-08

申请号：US18102024

申请日：2023-01-26

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2002/9528

Abstract: An assembly for replacement of a native aortic heart valve includes a radially collapsible prosthetic heart valve and a delivery apparatus. The prosthetic heart valve includes an annular frame with attachment posts, wherein each of the posts has an axial post portion and a transverse post portion having a greater circumferential dimension than the axial post portion. The delivery apparatus includes an inner shaft with a valve connection portion for releasably coupling to the attachment posts and an outer shaft having a sheath for maintaining the prosthetic heart valve in a radially compressed state. Rotation of a control knob on a handle causes the sheath to retract for uncovering a portion of the prosthetic heart valve. Further rotation of the control knob allows the posts to decouple from the delivery apparatus such that the prosthetic heart valve self-expands to a fully expanded state.

公开(公告)号：US11116631B2

公开(公告)日：2021-09-14

申请号：US17002636

申请日：2020-08-25

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: A method of delivering a prosthetic heart valve to a native aortic heart valve region of a patient can include introducing a prosthetic heart valve on a transvascular delivery apparatus into an artery of the patient, advancing the delivery apparatus through an aorta of the patient to the native aortic heart valve region, and releasing the prosthetic heart valve from the delivery apparatus. The delivery apparatus can have a shaft with a valve connection portion that is releasably coupled to posts of the prosthetic heart valve. The delivery apparatus can have a delivery sheath positioned around the prosthetic heart valve and the valve connection portion. The releasing the prosthetic valve can include moving the delivery sheath proximally relative to the shaft and the prosthetic heart valve such that the delivery sheath uncovers the prosthetic heart valve and the prosthetic heart valve can self-expand.

公开(公告)号：US20210236279A1

公开(公告)日：2021-08-05

申请号：US17235230

申请日：2021-04-20

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

IPC: A61F2/24

Abstract: A prosthetic heart valve includes a collapsible and expandable annular frame. The frame includes a plurality of rows of hexagonal cells. Each of the hexagonal cells is defined by six struts, including: two opposing side struts extending parallel to each other, a first pair of angled struts extending from respective first ends of the side struts and converging to intersect with each other, and a second pair of angled struts extending from respective second ends of the side struts and converging to intersect with each other. The prosthetic heart valve can also include a valvular structure with a plurality of leaflets. The prosthetic heart valve can further include a sealing member.