公开(公告)号：US11730597B2

公开(公告)日：2023-08-22

申请号：US18102024

申请日：2023-01-26

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2/9517 ,  A61F2/9522 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/001 ,  A61F2230/0054 ,  A61F2230/0076 ,  A61F2250/0039

Abstract: An assembly for replacement of a native aortic heart valve includes a radially collapsible prosthetic heart valve and a delivery apparatus. The prosthetic heart valve includes an annular frame with attachment posts, wherein each of the posts has an axial post portion and a transverse post portion having a greater circumferential dimension than the axial post portion. The delivery apparatus includes an inner shaft with a valve connection portion for releasably coupling to the attachment posts and an outer shaft having a sheath for maintaining the prosthetic heart valve in a radially compressed state. Rotation of a control knob on a handle causes the sheath to retract for uncovering a portion of the prosthetic heart valve. Further rotation of the control knob allows the posts to decouple from the delivery apparatus such that the prosthetic heart valve self-expands to a fully expanded state.

公开(公告)号：US20220079756A1

公开(公告)日：2022-03-17

申请号：US17456355

申请日：2021-11-23

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24

Abstract: Prosthetic heart valves and methods of implantation thereof are disclosed herein. In embodiments, a prosthetic heart valve includes a self-expandable frame configured to support of valve member and comprising a plurality of interconnected strut members forming a mesh structure. An inflow end and outflow end portions of the mesh structure respectively define an inflow terminal end and an outflow terminal end of the frame. A portion of the frame tapers inwardly from the inflow terminal end to form a reduced diameter section. In implementations, the frame increases in diameter from the reduced diameter section to an intermediate section. In implementations, the valve member is secured to the frame at the inflow end portion. In implementations, the frame further comprises a plurality of retaining arms that extend from the outflow terminal end and are configured to engage with a valve retaining mechanism of a delivery apparatus.

公开(公告)号：US11141274B2

公开(公告)日：2021-10-12

申请号：US17028719

申请日：2020-09-22

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan Otto Solem ,  David Alon

IPC: A61F2/24

Abstract: A method of treating a defective heart valve includes inserting a delivery catheter through a small incision in a patient's groin, wherein the delivery catheter has a prosthetic device positioned along a distal end. The prosthetic device includes an insert member and an anchoring member. The insert member is positioned between the native heart valve and is allowed to self-expand. The anchoring member is preferably a stent connected to the insert member by at least one elongate member. The stent is deployed within an adjacent blood vessel for anchoring the insert member between the native leaflets. After deployment of the prosthetic device, the native leaflets of the heart valve form a tight seal against the insert member for preventing regurgitation through the native heart valve during ventricular systole.

公开(公告)号：US11141270B2

公开(公告)日：2021-10-12

申请号：US17185135

申请日：2021-02-25

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: A prosthetic heart valve for replacing a defective aortic valve includes a self-expandable annular frame made of shape-memory material. A one-way valve structure is disposed within an interior of the frame. The frame includes a plurality of posts projecting axially from an outflow end portion of the frame, wherein each of the posts includes an axial post portion and a terminal post portion. The terminal post portions have greater circumferential dimensions than the axial post portions. The terminal post portions are preferably formed with concave inner surfaces and convex outer surfaces for conforming to the shape of a delivery catheter. Each of the posts is shaped for placement within a corresponding recess along a distal end portion of the delivery catheter for ensuring that the prosthetic heart valve remains coupled to the delivery catheter while the prosthetic heart valve is expanded within the defective aortic valve.

公开(公告)号：US10932906B2

公开(公告)日：2021-03-02

申请号：US16997890

申请日：2020-08-19

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: An assembly for transvascular replacement of a native aortic heart valve can have a radially collapsible and self-expandable prosthetic heart valve and a delivery apparatus. The valve can have an annular metal frame made of a shape-memory material with a plurality of posts extending from an end portion of the frame. The delivery apparatus can have a shaft comprising a valve connection portion that is releasably coupled to the posts of the valve. The valve connection portion can have a plurality of discrete radially facing recesses that receive the posts. The delivery apparatus can have a delivery sheath that is positioned around the prosthetic heart valve and the valve connection portion of the shaft to maintain the prosthetic heart valve in a radially compressed state and maintain the posts within the recesses. The delivery apparatus can cause relative axial motion between the delivery sheath and the valve.

公开(公告)号：US20210045874A1

公开(公告)日：2021-02-18

申请号：US17076705

申请日：2020-10-21

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24

Abstract: A handle assembly for a transvascular prosthetic heart valve delivery apparatus including a handle housing, a main shaft extending distally from the handle housing, the main shaft configured to be coupled to a distal valve sheath that is configured to retain a prosthetic heart valve in a radially compressed state within the valve sheath, a screw shaft, a control knob that is rotatable relative to the handle housing and the screw shaft, a screw engagement latch that is adjustable between an engaged position and a disengaged position. In the engaged position, the latch can couple the control knob to the screw shaft such that rotation of the control knob relative to the handle housing causes the main shaft to move axially relative to the handle housing. In the disengaged position, the latch can decouple the control knob from the screw shaft such that the main shaft can move axially relative to the handle housing without rotation of the control knob.

公开(公告)号：US20210015608A1

公开(公告)日：2021-01-21

申请号：US17028719

申请日：2020-09-22

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan Otto Solem ,  David Alon

IPC: A61F2/24

Abstract: A method of treating a defective heart valve includes inserting a delivery catheter through a small incision in a patient's groin, wherein the delivery catheter has a prosthetic device positioned along a distal end. The prosthetic device includes an insert member and an anchoring member. The insert member is positioned between the native heart valve and is allowed to self-expand. The anchoring member is preferably a stent connected to the insert member by at least one elongate member. The stent is deployed within an adjacent blood vessel for anchoring the insert member between the native leaflets. After deployment of the prosthetic device, the native leaflets of the heart valve form a tight seal against the insert member for preventing regurgitation through the native heart valve during ventricular systole.

公开(公告)号：US10820994B2

公开(公告)日：2020-11-03

申请号：US15954193

申请日：2018-04-16

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: Methods for delivering a prosthetic valve comprise introducing the prosthetic heart valve into a body of a patient. The prosthetic valve is mounted within a delivery sheath of a delivery apparatus in a radially compressed state. The prosthetic valve is advanced through the body to a delivery location. A motor is actuated to cause the delivery sheath to retract to expose the prosthetic valve and the prosthetic valve expands to a radially expanded state at the delivery location. The methods can also include releasing the prosthetic valve from the delivery apparatus and removing the delivery apparatus from the patient.

公开(公告)号：US10806575B2

公开(公告)日：2020-10-20

申请号：US16743316

申请日：2020-01-15

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： David Alon ,  Netanel Benichou ,  Oded Robert Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: A delivery assembly includes a prosthetic device, a catheter shaft, a release wire, a first line, and a second line. The prosthetic device has a first arm and a second arm. The release wire extends through the catheter shaft. The first line includes a first loop. The first line extends from the catheter shaft, through the first arm of the prosthetic device, and to the release wire, where the release wire extends through the first loop. The second line includes a second loop. The second line extends from the catheter shaft, through the second arm of the prosthetic device, and to the release wire, where the release wire extends through the second loop.

公开(公告)号：US20200170793A1

公开(公告)日：2020-06-04

申请号：US16783005

申请日：2020-02-05

Applicant: Edwards Lifesciences Corporation

Inventor： Michael J. Popp ,  David Alon ,  Jun Liu ,  Luca Pesce ,  Mohammad Jafari

IPC: A61F2/24 ,  A61F2/00

Abstract: A handle for a prosthetic heart valve delivery apparatus includes a housing, a motorized mechanism, and a holding mechanism. The housing is configured to be hand-held by a user and includes a distal opening. The motorized mechanism is disposed within the housing and is configured to be releasably coupled to a proximal end portion of a first shaft of the prosthetic heart valve delivery apparatus. When actuated, the motorized mechanism is configured to rotate the first shaft relative to the housing. The holding mechanism is disposed inside the housing and is configured to engage a proximal end portion of a second shaft of the prosthetic heart valve delivery apparatus such that the second shaft is axially and rotationally fixed relative to the housing, and the first shaft extends through the second shaft.