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31.发明申请Methods of Treating Post-Traumatic Stress Disorder Using Pro-Neurogenic Compounds 有权使用Pro-Neurogenic化合物治疗创伤后应激障碍的方法公开(公告)号：US20130184301A1
公开(公告)日：2013-07-18
申请号：US13740876
申请日：2013-01-14
IPC分类号： C07D471/04 , C07D403/12 , C07D413/06 , C07D209/08 , C07D209/88 , C07D401/06
CPC分类号： C07D209/88 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4045 , A61K31/4155 , A61K31/4192 , A61K31/422 , A61K31/437 , A61K31/4439 , A61K31/506 , C07D209/08 , C07D209/14 , C07D209/86 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D471/04
摘要： This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death.
摘要翻译： 本发明一般涉及刺激神经发生（例如，产后神经发生，例如产后海马神经发生）和保护神经元细胞死亡。
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公开(公告)号：US10172827B2
公开(公告)日：2019-01-08
申请号：US14996596
申请日：2016-01-15
IPC分类号： C07D209/88 , A61K31/403 , A61K31/00 , A61K31/415 , A61K31/437 , A61K31/44 , A61K31/506 , C07D209/86 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D471/04 , C07D209/08 , C07D401/12 , A61K31/404 , A61K31/4155 , A61K31/4192 , A61K31/422 , A61K31/4439 , A61P25/16 , A61P25/28 , A61P25/18
摘要： This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death.
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公开(公告)号：US20170305906A1
公开(公告)日：2017-10-26
申请号：US15644500
申请日：2017-07-07
IPC分类号： C07D471/04 , C07D405/06 , C07D403/06 , C07D223/24 , C07D209/90 , A61K31/55 , A61K31/519 , C07D487/04 , A61K31/403
CPC分类号： C07D471/04 , A61K31/403 , A61K31/519 , A61K31/55 , C07D209/90 , C07D223/24 , C07D403/06 , C07D405/06 , C07D487/04
摘要： Compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.
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公开(公告)号：US20170157092A1
公开(公告)日：2017-06-08
申请号：US15440396
申请日：2017-02-23
发明人： Steven L. McKnight , Andrew A. Pieper , Joseph M. Ready , Jef K. De Brabander , Jeffrey M. Zigman
IPC分类号： A61K31/4045 , A61K31/422 , A61K31/506 , A61K31/4192 , A61K31/5377 , A61K31/429 , A61K31/69 , A61K31/4188 , A61K31/41 , A61K31/4439 , A61K31/4155
CPC分类号： A61K31/4045 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/4155 , A61K31/4188 , A61K31/4192 , A61K31/422 , A61K31/429 , A61K31/437 , A61K31/44 , A61K31/4425 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K31/69 , C07D209/04 , C07D209/08 , C07D209/82 , C07D209/86 , C07D209/88 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/06 , C07D413/06 , C07D413/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07F5/022 , C07F7/0812
摘要： This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.
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公开(公告)号：US09645139B2
公开(公告)日：2017-05-09
申请号：US14945629
申请日：2015-11-19
发明人： Steven L. McKnight , Joseph M. Ready , Andrew A. Pieper , Gelin Wang , Ting Han
CPC分类号： G01N33/5058 , A61K38/00 , C12Q1/48 , G01N33/5014 , G01N33/5038 , G01N2333/91142
摘要： Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.
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公开(公告)号：US20160272619A1
公开(公告)日：2016-09-22
申请号：US15035909
申请日：2014-11-11
IPC分类号： C07D401/12 , C07D209/88
CPC分类号： C07D401/12 , C07D209/88
摘要： Provided herein are compositions and methods for reducing one or both of axonal degeneration and neuronal cell death associated with a disease or traumatic brain injury. An aminopropyl carbazole agent with potent neuroprotective properties is described. Specifically, (−)-(S)—N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine, is proposed as a new pharmacological agent for protecting patients against axonal degeneration and chronic consequences of TBI.
摘要翻译： 本文提供用于减少与疾病或创伤性脑损伤相关的轴突变性和神经元细胞死亡中的一种或两种的组合物和方法。 描述了具有有效神经保护性质的氨基丙基咔唑剂。 具体地说，提出了（ - ） - （S）-N-（3-（3,6-二溴-9H-咔唑-9-基）-2-氟丙基）-6-甲氧基吡啶-2-胺作为新的药理学 用于保护患者免受轴突变性和TBI慢性后果的药物。
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公开(公告)号：US09446042B2
公开(公告)日：2016-09-20
申请号：US14750119
申请日：2015-06-25
IPC分类号： A61K31/403 , A61K31/506 , C07D401/12 , A61K31/404 , A61K31/4045 , A61K31/437 , A61K31/4439 , C07D209/08 , C07D209/88 , C07D401/06 , C07D403/12 , C07D471/04 , C07D209/14 , C07D413/06 , C07D403/06 , A61K31/4035 , A61K31/4155 , A61K31/4192 , A61K31/422
CPC分类号： C07D209/88 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4045 , A61K31/4155 , A61K31/4192 , A61K31/422 , A61K31/437 , A61K31/4439 , A61K31/506 , C07D209/08 , C07D209/14 , C07D209/86 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D471/04
摘要： This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death.
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公开(公告)号：US09243281B2
公开(公告)日：2016-01-26
申请号：US14540006
申请日：2014-11-12
发明人： Steven L. McKnight , Joseph M. Ready , Andrew A. Pieper , Gelin Wang , Ting Han
CPC分类号： G01N33/5058 , A61K38/00 , C12Q1/48 , G01N33/5014 , G01N33/5038 , G01N2333/91142
摘要： Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.
摘要翻译： 本文提供了鉴定具有细胞保护（例如神经保护）活性的化合物的方法。 还提供了从其鉴定的化合物。 这些化合物可用于治疗与例如不想要的细胞死亡有关的各种疾病，病症或病症。
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公开(公告)号：US20150057301A1
公开(公告)日：2015-02-26
申请号：US14339742
申请日：2014-07-24
IPC分类号： C07D209/08 , C07D401/06 , C07D413/06 , C07D209/86 , C07D401/12 , C07D403/12 , C07D405/12 , C07D209/88 , C07D471/04
CPC分类号： A61K31/403 , A61K31/00 , A61K31/404 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/422 , A61K31/437 , A61K31/44 , A61K31/4439 , A61K31/506 , A61P25/16 , A61P25/18 , A61P25/28 , C07D209/08 , C07D209/86 , C07D209/88 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D471/04
摘要： This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protectiong from neuron cell death.
摘要翻译： 本发明一般涉及刺激神经发生（例如，产后神经发生，例如产后海马神经发生）和保护g免受神经元细胞死亡。
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公开(公告)号：US20140343018A1
公开(公告)日：2014-11-20
申请号：US14339772
申请日：2014-07-24
发明人： Steven L. McKnight , Andew A. Pieper , Joseph M. Ready , Jef K. De Brabander , Jeffrey M. Zigman
IPC分类号： C07D209/04 , C07D401/06 , C07D413/06 , C07D487/04 , C07D403/12 , C07D403/06 , C07F5/02 , C07D209/82 , C07D471/04
CPC分类号： A61K31/4045 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/4155 , A61K31/4188 , A61K31/4192 , A61K31/422 , A61K31/429 , A61K31/437 , A61K31/44 , A61K31/4425 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K31/69 , C07D209/04 , C07D209/08 , C07D209/82 , C07D209/86 , C07D209/88 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/06 , C07D413/06 , C07D413/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07F5/022 , C07F7/0812
摘要： This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.
摘要翻译： 该技术一般涉及用于刺激神经发生（例如产后神经发生，包括产后海马和下丘脑神经发生）和/或保护神经细胞免于细胞死亡的化合物和方法。 本文公开了各种化合物。 体内活性测试表明，这些化合物可能在神经精神和/或神经变性疾病如精神分裂症，主要抑郁症，双相性精神障碍，正常衰老，癫痫，创伤性脑损伤，创伤后应激障碍，帕金森病，阿尔茨海默病， 唐氏综合征，脊髓小脑性共济失调，肌萎缩性侧索硬化，亨廷顿病，中风，放射治疗，慢性应激，神经活性药物滥用，视网膜变性，脊髓损伤，周围神经损伤，与各种病症相关的生理体重减轻 作为与正常老化，化学疗法等相关的认知衰退。
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