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公开(公告)号：US20080249160A1
公开(公告)日：2008-10-09
申请号：US12105591
申请日：2008-04-18
申请人： Deryck J. Williams , Andrew P. Kloek , Michelle Coutu Hresko , Barry J. Shortt , Jennifer A. Davila-Aponte , John D. Bradley , James McCarter , Merry B. McLaird
发明人： Deryck J. Williams , Andrew P. Kloek , Michelle Coutu Hresko , Barry J. Shortt , Jennifer A. Davila-Aponte , John D. Bradley , James McCarter , Merry B. McLaird
摘要： Certain fatty acids and related compounds useful in the control nematodes that infest plants or the situs of plants are described. Nematodes that parasitize animals can also be controlled using the methods and compounds of this invention.
摘要翻译： 描述了可用于控制线虫的某些脂肪酸和相关化合物，其侵染植物或植物的部位。 也可以使用本发明的方法和化合物来控制寄生动物的线虫。
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公开(公告)号：US20080227955A1
公开(公告)日：2008-09-18
申请号：US12042297
申请日：2008-03-04
申请人： Michelle Coutu Hresko , Merry B. Mclaird , Deryck J. Williams , Anita M. Frevert , Brandi Chiapelli , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
发明人： Michelle Coutu Hresko , Merry B. Mclaird , Deryck J. Williams , Anita M. Frevert , Brandi Chiapelli , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
IPC分类号： C07K14/435
CPC分类号： C07K14/705
摘要： Nucleic acid molecules from nematodes encoding PAN and ZP domain containing receptor polypeptides are described. PANZP polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PANZP nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
摘要翻译： 描述了编码含有PAN和ZP结构域的受体多肽的线虫的核酸分子。 还提供PANZP多肽序列，载体，宿主细胞以及用于产生PANZP核苷酸和多肽的重组方法。 还描述了用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US20080227193A1
公开(公告)日：2008-09-18
申请号：US12061072
申请日：2008-04-02
申请人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
发明人： Andrew P. Kloek , Deryck J. Williams , Merry B. McLaird , John D. Bradley , Jennifer A. Davila-Aponte , Siqun Xu , Anita M. Frevert
CPC分类号： C12N9/0083 , C12N15/8247 , C12N15/8285 , G01N33/573 , G01N2333/4353 , Y02A40/164
摘要： Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
摘要翻译： 描述了编码脂肪酸去饱和酶多肽的线虫的核酸分子。 还提供了脂肪酸去饱和酶样多肽序列，以及用于产生脂肪酸去饱和酶样核苷酸和多肽的载体，宿主细胞和重组方法。 还描述了用于鉴定脂肪酸去饱和酶样多肽的抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US07368629B2
公开(公告)日：2008-05-06
申请号：US10912534
申请日：2004-08-04
申请人： Michelle L. Verbsky , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , Michelle Coutu Hresko , Merry B. McLaird , Rodolfo Zentella , Deryck J. Williams
发明人： Michelle L. Verbsky , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , Michelle Coutu Hresko , Merry B. McLaird , Rodolfo Zentella , Deryck J. Williams
CPC分类号： C12N9/0071 , C11B1/00 , C12N9/0073 , C12N15/8223 , C12N15/8247 , C12N15/8285 , Y02A40/164
摘要： The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues. Transgenic plants expressing such a polypeptide can also be useful for non-pesticidal industrial uses.
摘要翻译： 本发明提供了DNA构建体，含有这种构建体的转基因植物和制备植物的方法。 DNA构建体编码多肽，当表达导致产生具有驱肠虫活性的脂肪酸化合物时。 表达这种多肽的转基因植物可以表现出对植物寄生线虫的增强的抗性，特别是当在营养组织中表达时。 表达这种多肽的转基因植物也可用于非农药工业用途。
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公开(公告)号：US07250500B2
公开(公告)日：2007-07-31
申请号：US11191374
申请日：2005-07-28
申请人： Michelle Coutu Hresko , Merry B. McLaird , Deryck J. Williams , Anita M. Frevert , Brandi Chiapelli , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
发明人： Michelle Coutu Hresko , Merry B. McLaird , Deryck J. Williams , Anita M. Frevert , Brandi Chiapelli , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
CPC分类号： C07K14/705
摘要： Nucleic acid molecules from nematodes encoding PAN and ZP domain containing receptor polypeptides are described. PANZP polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PANZP nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
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公开(公告)号：US06936693B2
公开(公告)日：2005-08-30
申请号：US10771708
申请日：2004-02-04
申请人： Michelle Coutu Hresko , Merry B. McLaird , Deryck J. Williams , Anita M. Frevert , Brandi Chiapelli , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
发明人： Michelle Coutu Hresko , Merry B. McLaird , Deryck J. Williams , Anita M. Frevert , Brandi Chiapelli , Catherine Baublite , Andrew P. Kloek , Jennifer A. Davila-Aponte , John D. Bradley , Siqun Xu
IPC分类号： A61K38/17 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/705 , C07K17/00 , C12N20060101 , C12N15/00 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/705
摘要： Nucleic acid molecules from nematodes encoding PAN and ZP domain containing receptor polypeptides are described. PANZP polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PANZP nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
摘要翻译： 描述了编码含有PAN和ZP结构域的受体多肽的线虫的核酸分子。 还提供PANZP多肽序列，载体，宿主细胞以及用于产生PANZP核苷酸和多肽的重组方法。 还描述了用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。
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公开(公告)号：US06903052B2
公开(公告)日：2005-06-07
申请号：US10187683
申请日：2002-07-01
IPC分类号： A01N37/02 , A01N37/06 , A01N37/36 , A01N37/42 , A01N43/20 , A61K31/201 , A61K31/336 , A61K31/337 , A01N37/00 , A61K31/22 , A61K31/231 , A61K31/232
CPC分类号： A61K31/337 , A01N37/02 , A01N37/06 , A01N37/36 , A01N37/42 , A01N43/20 , A61K31/201 , A61K31/336 , Y10S514/946 , A01N2300/00
摘要： The invention concerns the use of certain compounds related to fatty acids to control nematodes that infest plants or the situs of plants. Nematodes that parasitize animals can also be controlled using the methods and composition of this invention. Certain of the useful compounds are fatty acid esters that are predicted inhibitors of nematode delta-12 fatty acid desaturases and can be, for example, from C16 to C20 in length.
摘要翻译： 本发明涉及使用某些与脂肪酸有关的化合物来控制侵染植物或植物部位的线虫。 也可以使用本发明的方法和组合物来控制寄生动物的线虫。 某些有用的化合物是作为线虫δ-12脂肪酸去饱和酶的预测抑制剂的脂肪酸酯，其长度可例如为C16至C20。
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