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    End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
    31.
    发明授权
    End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids 失效
    将寡核苷酸结合到聚丙烯酰胺固体支持物上用于捕获和检测核酸

    公开(公告)号：US5237016A

    公开(公告)日：1993-08-17

    申请号：US293893

    申请日：1989-01-05

    Applicant: Soumitra S. Ghosh ,  Eoin D. Fahy

    Inventor： Soumitra S. Ghosh ,  Eoin D. Fahy

    IPC: C07H21/00 ,  C12Q1/68

    CPC classification number: C07H21/00

    Abstract: This invention concerns methods and means for covalent attachment of oligonucleotides to solid supports substantially at their 5'-ends. According to the invention thiol-oligonucleotides are attached to bromoacetyl-derivatized polyacrylamide supports, or conversely, bromoacetyl-oligonucleotides are immobilized on thiol-polyacrylamide supports.In a further aspect, this invention relates to bromoacetyl-oligonucleotides that may be immobilized on thiol-polyacrylamide solid supports, thiol-oligonucleotides immobilized on bromoacetyl-derivatized polyacrylamide supports as well as to methods for capture of nucleic acids by oligonucleotides attached to polyacrylamide solid supports, either by direct capture or in sandwich hybridization formats.

    Abstract translation: 本发明涉及将寡核苷酸共价连接到基本上在其5'端的固体支持物的方法和手段。 根据本发明，硫醇 - 寡核苷酸连接到溴乙酰基衍生的聚丙烯酰胺载体上，或者相反地，溴乙酰基寡核苷酸被固定在巯基 - 聚丙烯酰胺载体上。 在另一方面，本发明涉及可固定在硫醇 - 聚丙烯酰胺固体支持物上的溴乙酰基寡核苷酸，固定在溴乙酰基衍生的聚丙烯酰胺载体上的硫醇寡核苷酸以及通过与聚丙烯酰胺固体支持物连接的寡核苷酸捕获核酸的方法 ，通过直接捕获或夹心杂交形式。

    ENGINEERED POLYPEPTIDES HAVING ENHANCED DURATION OF ACTION AND REDUCED IMMUNOGENICITY
    32.
    发明申请
    ENGINEERED POLYPEPTIDES HAVING ENHANCED DURATION OF ACTION AND REDUCED IMMUNOGENICITY 有权
    具有增强作用时间和降低免疫原性的工程多糖

    公开(公告)号：US20160207974A1

    公开(公告)日：2016-07-21

    申请号：US14837705

    申请日：2015-08-27

    Applicant: Mary Erickson ,  David C. Litzinger ,  Soumitra S. Ghosh ,  Zijian Guo ,  Caroline Ekblad ,  Jonathan D. Roth

    Inventor： Mary Erickson ,  David C. Litzinger ,  Soumitra S. Ghosh ,  Zijian Guo ,  Caroline Ekblad ,  Jonathan D. Roth

    IPC: C07K14/575 ,  C07K14/315

    CPC classification number: C07K14/5759 ,  A61K38/00 ,  A61K38/22 ,  A61K38/2264 ,  C07K14/315 ,  C07K14/575 ,  C07K2319/31 ,  C07K2319/70

    Abstract: Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including lipodystrophy, dyslipidemia, hyperlipidemia, overweight, obesity, hypothalamic amenorrhea, Alzheimer's disease, leptin deficiency, fatty liver disease or diabetes (including type I and type II). Additional diseases and disorders which can be treated by the compounds and methods described herein include nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD), metabolic syndrome X and Huntington's Disease.

    Abstract translation: 提供化合物尤其具有良好的作用持续时间，高效力和/或方便的给药方案，包括每周给药一次。 所述化合物是结合一种或多种生物活性多肽的白蛋白结合结构域的工程多肽。 还提供了包括脂肪营养不良，血脂异常，高脂血症，超重，肥胖，下丘脑闭经，阿尔茨海默病，瘦素缺乏症，脂肪肝疾病或糖尿病（包括I型和II型）的疾病和病症的药物组合物和治疗方法。 可以通过本文所述的化合物和方法治疗的其它疾病和病症包括非酒精性脂肪性肝炎（NASH）和非酒精性脂肪性肝病（NAFLD），代谢综合征X和亨廷顿氏病。

    Aryl N-cyanoguanidines and methods related thereto
    38.
    发明授权
    Aryl N-cyanoguanidines and methods related thereto 失效
    芳基N-氰基胍及其相关方法

    公开(公告)号：US07230132B2

    公开(公告)日：2007-06-12

    申请号：US11040196

    申请日：2005-01-21

    Applicant: Soumitra S Ghosh ,  Tomas R Szabo

    Inventor： Soumitra S Ghosh ,  Tomas R Szabo

    IPC: C07C279/28 ,  C07C279/18

    CPC classification number: A61K31/5375 ,  A61K31/155 ,  C07C279/28

    Abstract: Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.

    Abstract translation: 治疗关节炎疾病如骨关节炎或类风湿性关节炎的化合物，组合物和方法，以及用于治疗与线粒体功能改变相关的其它疾病，例如癌症，牛皮癣，中风，阿尔茨海默氏病和糖尿病。 本发明的化合物具有以下结构（I）：包括其立体异构体，前药和药学上可接受的盐，其中R 1-5如本文所定义。 本发明的方法涉及向有需要的温血动物施用有效量的结构式（I）的化合物，通常为药物组合物的形式。

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