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    ENGINEERED POLYPEPTIDES HAVING ENHANCED DURATION OF ACTION AND REDUCED IMMUNOGENICITY
    1.
    发明申请
    ENGINEERED POLYPEPTIDES HAVING ENHANCED DURATION OF ACTION AND REDUCED IMMUNOGENICITY 有权
    具有增强作用时间和降低免疫原性的工程多糖

    公开(公告)号：US20160207974A1

    公开(公告)日：2016-07-21

    申请号：US14837705

    申请日：2015-08-27

    申请人： Mary Erickson ,  David C. Litzinger ,  Soumitra S. Ghosh ,  Zijian Guo ,  Caroline Ekblad ,  Jonathan D. Roth

    发明人： Mary Erickson ,  David C. Litzinger ,  Soumitra S. Ghosh ,  Zijian Guo ,  Caroline Ekblad ,  Jonathan D. Roth

    IPC分类号： C07K14/575 ,  C07K14/315

    CPC分类号： C07K14/5759 ,  A61K38/00 ,  A61K38/22 ,  A61K38/2264 ,  C07K14/315 ,  C07K14/575 ,  C07K2319/31 ,  C07K2319/70

    摘要： Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including lipodystrophy, dyslipidemia, hyperlipidemia, overweight, obesity, hypothalamic amenorrhea, Alzheimer's disease, leptin deficiency, fatty liver disease or diabetes (including type I and type II). Additional diseases and disorders which can be treated by the compounds and methods described herein include nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD), metabolic syndrome X and Huntington's Disease.

    摘要翻译： 提供化合物尤其具有良好的作用持续时间，高效力和/或方便的给药方案，包括每周给药一次。 所述化合物是结合一种或多种生物活性多肽的白蛋白结合结构域的工程多肽。 还提供了包括脂肪营养不良，血脂异常，高脂血症，超重，肥胖，下丘脑闭经，阿尔茨海默病，瘦素缺乏症，脂肪肝疾病或糖尿病（包括I型和II型）的疾病和病症的药物组合物和治疗方法。 可以通过本文所述的化合物和方法治疗的其它疾病和病症包括非酒精性脂肪性肝炎（NASH）和非酒精性脂肪性肝病（NAFLD），代谢综合征X和亨廷顿氏病。