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31.发明授权Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents 失效制备聚合物涂层的方法，接枝聚环氧乙烷链含有共价键合的生物活性剂
公开(公告)号：US5877263A
公开(公告)日：1999-03-02
申请号：US755189
申请日：1996-11-25
CPC分类号： A61L33/0029 , A61K47/48192 , A61K47/48215 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/10 , A61L33/0011 , Y10S623/90 , Y10T428/31551
摘要： Disclosed are bio-active coating compositions for polymeric substrates. In particular, a bio-active coating is described which is the reaction product formed by providing a polymer backbone with at least one free isocyanate group, wherein the isocyanate group is pendant from the polymer backbone. There is further provided a hydrophilic, amine-terminated spacer which has at least one amine group at its first and second ends. One of the amine groups of the spacer is reacted with one or more of the isocyanate groups on the polymer backbone in the presence of an optional catalyst agent. A bio-active agent is then covalently bonded onto an unreacted end of the spacer in the presence of a catalyst. Also disclosed are coating compositions for a substrate and methods of preparing same.
摘要翻译： 公开了用于聚合物基材的生物活性涂料组合物。 特别地，描述了生物活性涂层，其是通过向聚合物主链提供至少一个游离异氰酸酯基团形成的反应产物，其中异氰酸酯基团从聚合物主链悬挂。 还提供亲水的胺封端的间隔物，其在其第一和第二端具有至少一个胺基。 在任选的催化剂存在下，间隔基的一个胺基与聚合物主链上的一个或多个异氰酸酯基团反应。 然后在催化剂的存在下将生物活性剂共价键合到间隔物的未反应端上。 还公开了用于底物的涂料组合物及其制备方法。
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32.发明授权Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin 失效用聚乙烯氧化物链接枝的含有共价键合肝素的聚氨酯
公开(公告)号：US5855618A
公开(公告)日：1999-01-05
申请号：US713803
申请日：1996-09-13
CPC分类号： A61L33/0047 , A61L27/34 , A61L33/0029 , A61L33/0094
摘要： Disclosed are bio-active polymer coatings. More particularly, improved bio-active polymer coating are disclosed which include bio-active molecules attached to polyurethane backbones via amine-terminated spacers. Also disclosed are novel reaction schemes for producing same.
摘要翻译： 公开了生物活性聚合物涂层。 更具体地，公开了改进的生物活性聚合物涂层，其包括通过胺封端的间隔物连接到聚氨酯主链上的生物活性分子。 还公开了用于制备其的新型反应方案。
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公开(公告)号：US4844986A
公开(公告)日：1989-07-04
申请号：US155904
申请日：1988-02-16
IPC分类号： A61L29/00 , A61L29/08 , A61M5/32 , A61M25/00 , B05D3/10 , B05D5/00 , B05D7/02 , B05D7/24 , C08J5/16 , C08J7/04 , C08J7/12 , C09D4/00 , C10M107/50 , C10N40/00 , C10N80/00 , C23C14/12 , C23C16/30
CPC分类号： C10M107/50 , A61L29/085 , C08J7/047 , C08J7/12 , C09D4/00 , C08J2383/02 , C10M2229/041 , C10M2229/052 , C10N2220/02 , C10N2240/00 , C10N2240/22 , C10N2240/30 , C10N2240/50 , C10N2240/52 , C10N2240/54 , C10N2240/56 , C10N2240/58 , C10N2240/60 , C10N2240/66
摘要： A method for preparing stable even coatings of a silicone lubricant on a low surface energy polymeric surface of an article includes plasma treatment of the surface in an atmosphere of a siloxane monomer. A layer of polysiloxane is deposited on the low energy surface to give a polysiloxane surface. A film of a polysiloxane lubricant having a surface tension substantially the same as or less than the surface energy of the polysiloxane surface is applied to the polysiloxane layer.
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公开(公告)号：US4841007A
公开(公告)日：1989-06-20
申请号：US173892
申请日：1988-03-28
CPC分类号： C08G18/5015 , A61L33/068 , C08G18/10
摘要： Non-blocking, hemocompatible, thermoplastic, fluorinated polyetherurethanes and a method for their preparation from fluorinated polyether glycols, isocyanates, chain extenders and a non-fluorinated polyol. The method includes two steps in which the fluorinated glycol is reacted initially with the diisocyanate to give a prepolymer having terminal isocyanate groups, and the prepolymer is then reacted with the extender and non-fluorinated polyol. Medical devices are fabricated from the fluorinated polyetherurethane.
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35.发明授权
公开(公告)号：US4816130A
公开(公告)日：1989-03-28
申请号：US133767
申请日：1987-12-14
CPC分类号： G01N27/40 , B01D71/54 , C08G18/12 , C08G18/4833 , C08G18/6677
摘要： Partition membranes which are permeable to blood electrolytes fabricated from crosslinked polyetherurethane compositions having from 20 to 50% hard segments. The membranes absorb from 50 to 120% of their dry weight of water and have electrolyte diffusion constants of up to 1.times.10.sup.-6 cm.sup.2 /sec. The membranes are included in electrochemical, fiber optic and solid state blood electrolyte sensors to provide blood compatible surfaces and to ensure that blood components deleterious to analysis of electrolyte in the blood remain separated from the sensing elements.
摘要翻译： 由具有20至50％硬链段的交联聚醚聚氨酯组合物制备的可渗透血液电解质的分隔膜。 膜吸收其干重量的50至120％，电解质扩散常数高达1×10-6cm2 / sec。 膜被包括在电化学，光纤和固态血液电解质传感器中，以提供血液相容性表面，并确保对血液中电解质分析有害的血液成分与感测元件分离。
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