公开(公告)号：US20060058311A1

公开(公告)日：2006-03-16

申请号：US11189540

申请日：2005-07-26

Applicant: Gerd Munzert ,  Martin Steegmaier ,  Anke Baum

Inventor： Gerd Munzert ,  Martin Steegmaier ,  Anke Baum

IPC: A61K31/525

CPC classification number: A61K31/4985 ,  A61K31/435 ,  A61K31/4409 ,  A61K31/519

Abstract: Disclosed are pharmaceutical compositions for the treatment of diseases which involve cell proliferation. Also disclosed are methods for the treatment of said diseases, comprising co-administration of a compound 1 of Formula (I) wherein the groups L, R1, R2, R3, R4 and R5 have the meanings given herein and of an effective amount of an active compound 2 and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of a compound 1 of Formula (I) and of an effective amount of an active compound 2 and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

Abstract translation: 公开了用于治疗涉及细胞增殖的疾病的药物组合物。 还公开了治疗所述疾病的方法，包括共同给予式（I）化合物1，

公开(公告)号：US06861422B2

公开(公告)日：2005-03-01

申请号：US10374876

申请日：2003-02-26

Applicant: Matthias Hoffmann ,  Matthias Grauert ,  Trixi Brandl ,  Steffen Breitfelder ,  Christian Eickmeier ,  Martin Steegmaier ,  Gisela Schnapp ,  Anke Baum ,  Jens Juergen Quant ,  Flavio Solca ,  Florian Colbatzky

Inventor： Matthias Hoffmann ,  Matthias Grauert ,  Trixi Brandl ,  Steffen Breitfelder ,  Christian Eickmeier ,  Martin Steegmaier ,  Gisela Schnapp ,  Anke Baum ,  Jens Juergen Quant ,  Flavio Solca ,  Florian Colbatzky

IPC: A61P35/00 ,  C07D475/00 ,  C07D519/00 ,  C07D487/04 ,  A61K31/4985

CPC classification number: C07D295/073 ,  C07D475/00

Abstract: The present invention relates to new dihydropteridinones of general formula (I): wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.

Abstract translation: 本发明涉及通式（I）的新的二氢蝶啶酮：其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶的方法和用途 作为药物组合物。

公开(公告)号：US20050014760A1

公开(公告)日：2005-01-20

申请号：US10903807

申请日：2004-07-30

Applicant: Matthias Hoffmann ,  Matthias Grauert ,  Trixi Brandl ,  Steffen Breitfelder ,  Christian Eickmeier ,  Martin Steegmaier ,  Gisela Schnapp ,  Anke Baum ,  Jens Quant ,  Flavio Solca ,  Florian Colbatzky

Inventor： Matthias Hoffmann ,  Matthias Grauert ,  Trixi Brandl ,  Steffen Breitfelder ,  Christian Eickmeier ,  Martin Steegmaier ,  Gisela Schnapp ,  Anke Baum ,  Jens Quant ,  Flavio Solca ,  Florian Colbatzky

IPC: A61P35/00 ,  C07D475/00 ,  C07D519/00 ,  A61K31/525

CPC classification number: C07D295/073 ,  C07D475/00

Abstract: Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.

Abstract translation: 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶呤的中间体和方法及其用途 药物组合物。

公开(公告)号：US08207349B2

公开(公告)日：2012-06-26

申请号：US12685213

申请日：2010-01-11

Applicant: Bodo Betzemeier ,  Trixi Brandl ,  Steffen Breitfelder ,  Ralph Brueckner ,  Thomas Gerstberger ,  Michael Gmachl ,  Matthias Grauert ,  Frank Hilberg ,  Christoph Hoenke ,  Matthias Hoffmann ,  Maria Impagnatiello ,  Dirk Kessler ,  Christian Klein ,  Bernd Krist ,  Udo Maier ,  Darryl McConnell ,  Charlotte Reither ,  Stefan Scheuerer ,  Andreas Schoop ,  Norbert Schweifer ,  Oliver Simon ,  Martin Steegmaier ,  Steffen Steurer ,  Irene Waizenegger ,  Ulrike Weyer-Czernilofsky ,  Andreas Zoephel

Inventor： Bodo Betzemeier ,  Trixi Brandl ,  Steffen Breitfelder ,  Ralph Brueckner ,  Thomas Gerstberger ,  Michael Gmachl ,  Matthias Grauert ,  Frank Hilberg ,  Christoph Hoenke ,  Matthias Hoffmann ,  Maria Impagnatiello ,  Dirk Kessler ,  Christian Klein ,  Bernd Krist ,  Udo Maier ,  Darryl McConnell ,  Charlotte Reither ,  Stefan Scheuerer ,  Andreas Schoop ,  Norbert Schweifer ,  Oliver Simon ,  Martin Steegmaier ,  Steffen Steurer ,  Irene Waizenegger ,  Ulrike Weyer-Czernilofsky ,  Andreas Zoephel

IPC: C07D277/60

CPC classification number: C07D513/04 ,  C07D277/84

Abstract: The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.

Abstract translation: 本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗特征为过度或异常细胞增殖的疾病，以及其用于制备具有上述 属性。

公开(公告)号：US20100113414A1

公开(公告)日：2010-05-06

申请号：US12685213

申请日：2010-01-11

Applicant: Bodo BETZEMEIER ,  Trixi BRANDL ,  Steffen BREITFELDER ,  Ralph BRUECKNER ,  Thomas GERSTBERGER ,  Michael GMACHL ,  Matthias GRAUERT ,  Frank HILBERG ,  Christoph HOENKE ,  Matthias HOFFMANN ,  Maria IMPAGNATIELLO ,  Dirk KESSLER ,  Christian KLEIN ,  Bernd KRIST ,  Udo MAIER ,  Darryl McCONNELL ,  Charlotte REITHER ,  Stefan SCHEUERER ,  Andreas SCHOOP ,  Norbert SCHWEIFER ,  Oliver SIMON ,  Martin STEEGMAIER ,  Steffen STEURER ,  Irene WAIZENEGGER ,  Ulrike WEYER-CZERNILOFSKY ,  Andreas ZOEPHEL

Inventor： Bodo BETZEMEIER ,  Trixi BRANDL ,  Steffen BREITFELDER ,  Ralph BRUECKNER ,  Thomas GERSTBERGER ,  Michael GMACHL ,  Matthias GRAUERT ,  Frank HILBERG ,  Christoph HOENKE ,  Matthias HOFFMANN ,  Maria IMPAGNATIELLO ,  Dirk KESSLER ,  Christian KLEIN ,  Bernd KRIST ,  Udo MAIER ,  Darryl McCONNELL ,  Charlotte REITHER ,  Stefan SCHEUERER ,  Andreas SCHOOP ,  Norbert SCHWEIFER ,  Oliver SIMON ,  Martin STEEGMAIER ,  Steffen STEURER ,  Irene WAIZENEGGER ,  Ulrike WEYER-CZERNILOFSKY ,  Andreas ZOEPHEL

IPC: A61K31/397 ,  C07D417/14 ,  A61K31/4439 ,  C07D513/02 ,  A61K31/429 ,  C07D213/02 ,  A61K31/4545 ,  C07D401/14 ,  A61K31/444 ,  C07D403/02 ,  A61K31/497 ,  A61K31/506 ,  C07D413/14 ,  A61K31/5377 ,  C07D267/10 ,  A61K31/553 ,  C07D223/02 ,  A61K31/55 ,  C07D243/08 ,  A61K31/551 ,  A61P35/00

CPC classification number: C07D513/04 ,  C07D277/84

Abstract: The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.

Abstract translation: 本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗特征为过度或异常细胞增殖的疾病，以及其用于制备具有上述 属性。

公开(公告)号：US07709480B2

公开(公告)日：2010-05-04

申请号：US11313380

申请日：2005-12-21

Applicant: Georg Dahmann ,  Frank Himmelsbach ,  Bernd Krist ,  Martin Lenter ,  Alexander Pautsch ,  Gisela Schapp ,  Martin Steegmaier ,  Helmut Wittneben ,  Anthony S. Prokopowicz ,  Walter Spevak ,  Andreas Schoop ,  Steffen Steurer

Inventor： Georg Dahmann ,  Frank Himmelsbach ,  Bernd Krist ,  Martin Lenter ,  Alexander Pautsch ,  Gisela Schapp ,  Martin Steegmaier ,  Helmut Wittneben ,  Anthony S. Prokopowicz ,  Walter Spevak ,  Andreas Schoop ,  Steffen Steurer

IPC: C07D417/00 ,  C07D239/48 ,  A61K31/506

CPC classification number: C07D239/48 ,  C07D231/12 ,  C07D233/56 ,  C07D239/50 ,  C07D239/80 ,  C07D249/08 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D451/04 ,  C07D451/06 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10

Abstract: The present invention relates to trisubstituted pyrimidines of formula (I) wherein 0Ra to Re are defined as in claim 1, which are suitable for the treatment of illnesses characterized by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.

Abstract translation: 本发明涉及式（I）的三取代嘧啶，其中0Ra至Re如权利要求1所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，其用于制备具有上述药物组合物的用途 性质及其制备方法。

公开(公告)号：US20090306067A1

公开(公告)日：2009-12-10

申请号：US12296829

申请日：2007-04-04

Applicant: Harald Engelhardt ,  Heinz Stadtmueller ,  Martin Steegmaier

Inventor： Harald Engelhardt ,  Heinz Stadtmueller ,  Martin Steegmaier

IPC: A61K31/538 ,  C07D487/04 ,  A61K31/4985 ,  C07D498/04 ,  A61P35/00

CPC classification number: C07D487/04 ,  C07D403/12 ,  C07D409/12 ,  C07D519/00

Abstract: The present invention encompasses compounds of general formula (1) wherein Q and R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.

Abstract translation: 本发明包括通式（1）的化合物，其中Q和R 1至R 4如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病，以及其用于制备具有 上述属性。

公开(公告)号：US20090163465A1

公开(公告)日：2009-06-25

申请号：US12366075

申请日：2009-02-05

Applicant: Heinz STADTMUELLER ,  Harald ENGELHARDT ,  Martin STEEGMAIER ,  Anke BAUM ,  Ulrich GUERTLER ,  Andreas SCHOOP ,  Jens Juergen QUANT ,  Flavio SOLCA ,  Rudolf HAUPTMANN ,  Ulrich REISER ,  Stephan Karl ZAHN ,  Lars HERFURTH

Inventor： Heinz STADTMUELLER ,  Harald ENGELHARDT ,  Martin STEEGMAIER ,  Anke BAUM ,  Ulrich GUERTLER ,  Andreas SCHOOP ,  Jens Juergen QUANT ,  Flavio SOLCA ,  Rudolf HAUPTMANN ,  Ulrich REISER ,  Stephan Karl ZAHN ,  Lars HERFURTH

IPC: A61K31/506 ,  A61K31/55 ,  A61K31/553 ,  A61K31/551 ,  A61P35/00

CPC classification number: C07D239/42 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/08 ,  C07D491/10

Abstract: The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.

公开(公告)号：US20080319190A1

公开(公告)日：2008-12-25

申请号：US12192472

申请日：2008-08-15

Applicant: Matthias GRAUERT ,  Matthias HOFFMANN ,  Martin STEEGMAIER ,  Flavio SOLCA ,  Jens QUANT

Inventor： Matthias GRAUERT ,  Matthias HOFFMANN ,  Martin STEEGMAIER ,  Flavio SOLCA ,  Jens QUANT

IPC: C07D487/04

CPC classification number: C07D295/155 ,  C07D487/04 ,  Y02P20/55

Abstract: Disclosed are new dihydropteridinones of the formula (I) wherein the groups L, R1, R2, R3, R4 and R5 have the meanings provided herein, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.

公开(公告)号：US07414053B2

公开(公告)日：2008-08-19

申请号：US11210379

申请日：2005-08-24

Applicant: Matthias Grauert ,  Matthias Hoffmann ,  Martin Steegmaier ,  Flavio Solca ,  Jens Juergen Quant

Inventor： Matthias Grauert ,  Matthias Hoffmann ,  Martin Steegmaier ,  Flavio Solca ,  Jens Juergen Quant

IPC: A61K31/5355 ,  A61K31/5025 ,  A61K31/4985 ,  C07D413/14 ,  C07D487/04 ,  C07D475/00 ,  C07D265/30 ,  C07D295/135 ,  C07D295/30 ,  C07D241/12 ,  A61P35/00

CPC classification number: C07D295/155 ,  C07D487/04 ,  Y02P20/55

Abstract: Disclosed are new dihydropteridinones of the formula (I) wherein the groups L, R1, R2, R3, R4 and R5 have the meanings provided herein, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.

Abstract translation: 公开了式（I）的新的二氢蝶啶酮，其中基团L，R 1，R 2，R 3，R 4， ＆lt;＆gt;和＆lt; 5＆gt;具有本文提供的含义，其异构体，制备这些二氢蝶啶烷的方法及其作为药物组合物的用途。