公开(公告)号：US20080319190A1

公开(公告)日：2008-12-25

申请号：US12192472

申请日：2008-08-15

Applicant: Matthias GRAUERT ,  Matthias HOFFMANN ,  Martin STEEGMAIER ,  Flavio SOLCA ,  Jens QUANT

Inventor： Matthias GRAUERT ,  Matthias HOFFMANN ,  Martin STEEGMAIER ,  Flavio SOLCA ,  Jens QUANT

IPC: C07D487/04

CPC classification number: C07D295/155 ,  C07D487/04 ,  Y02P20/55

Abstract: Disclosed are new dihydropteridinones of the formula (I) wherein the groups L, R1, R2, R3, R4 and R5 have the meanings provided herein, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.

公开(公告)号：US20060052383A1

公开(公告)日：2006-03-09

申请号：US11210951

申请日：2005-08-24

Applicant: Matthias Grauert ,  Matthias Hoffmann ,  Martin Steegmaier ,  Christian Eickmeier ,  Gisela Schnapp ,  Norbert Redemann ,  Flavio Solca ,  Jens Quant

Inventor： Matthias Grauert ,  Matthias Hoffmann ,  Martin Steegmaier ,  Christian Eickmeier ,  Gisela Schnapp ,  Norbert Redemann ,  Flavio Solca ,  Jens Quant

IPC: A61K31/525 ,  C07D475/02

CPC classification number: C07D487/04 ,  C07D475/00 ,  Y02P20/55

Abstract: Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.

Abstract translation: 公开了通式（I）的新的二氢蝶啶酮，

公开(公告)号：US20050014761A1

公开(公告)日：2005-01-20

申请号：US10909008

申请日：2004-07-30

Applicant: Matthias Hoffmann ,  Matthias Grauert ,  Trixi Brandl ,  Steffen Breitfelder ,  Christian Eickmeier ,  Martin Steegmaier ,  Gisela Schnapp ,  Anke Baum ,  Jens Quant ,  Flavio Solca ,  Florian Colbatzky

Inventor： Matthias Hoffmann ,  Matthias Grauert ,  Trixi Brandl ,  Steffen Breitfelder ,  Christian Eickmeier ,  Martin Steegmaier ,  Gisela Schnapp ,  Anke Baum ,  Jens Quant ,  Flavio Solca ,  Florian Colbatzky

IPC: A61P35/00 ,  C07D475/00 ,  C07D519/00 ,  A61K31/525 ,  C07D475/02

CPC classification number: C07D295/073 ,  C07D475/00

Abstract: Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.

Abstract translation: 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶呤的中间体和方法及其用途 药物组合物。

公开(公告)号：US20050014760A1

公开(公告)日：2005-01-20

申请号：US10903807

申请日：2004-07-30

Applicant: Matthias Hoffmann ,  Matthias Grauert ,  Trixi Brandl ,  Steffen Breitfelder ,  Christian Eickmeier ,  Martin Steegmaier ,  Gisela Schnapp ,  Anke Baum ,  Jens Quant ,  Flavio Solca ,  Florian Colbatzky

Inventor： Matthias Hoffmann ,  Matthias Grauert ,  Trixi Brandl ,  Steffen Breitfelder ,  Christian Eickmeier ,  Martin Steegmaier ,  Gisela Schnapp ,  Anke Baum ,  Jens Quant ,  Flavio Solca ,  Florian Colbatzky

IPC: A61P35/00 ,  C07D475/00 ,  C07D519/00 ,  A61K31/525

CPC classification number: C07D295/073 ,  C07D475/00

Abstract: Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.

Abstract translation: 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶呤的中间体和方法及其用途 药物组合物。

公开(公告)号：US20070207999A1

公开(公告)日：2007-09-06

申请号：US11675936

申请日：2007-02-16

Applicant: Heinz Stadtmueller ,  Anke Baum ,  Guido Boehmelt ,  Harald Engelhardt ,  Jens Quant ,  Flavio Solca ,  Martin Steegmaier ,  Stephan Zahn

Inventor： Heinz Stadtmueller ,  Anke Baum ,  Guido Boehmelt ,  Harald Engelhardt ,  Jens Quant ,  Flavio Solca ,  Martin Steegmaier ,  Stephan Zahn

IPC: A61K31/55 ,  A61K31/553 ,  C07D403/02 ,  C07D413/02

CPC classification number: C07D498/04 ,  C07D403/12 ,  C07D413/12 ,  C07D487/04

Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R6, X and Y are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, as well as the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.

Abstract translation: 本发明包括其中R 1至R 6的通式（1）的化合物，X和Y如权利要求1中所定义，其适用于治疗疾病 其特征在于过度或异常的细胞增殖，以及其用于制备具有上述性质的药物组合物的用途。

公开(公告)号：US20060025411A1

公开(公告)日：2006-02-02

申请号：US11219945

申请日：2005-09-06

Applicant: Matthias Hoffmann ,  Matthias Grauert ,  Martin Steegmaier ,  Anke Baum ,  Jens Quant ,  Flavio Solca ,  Florian Colbatzky

Inventor： Matthias Hoffmann ,  Matthias Grauert ,  Martin Steegmaier ,  Anke Baum ,  Jens Quant ,  Flavio Solca ,  Florian Colbatzky

IPC: A61K31/5377 ,  C07D475/02 ,  A61K31/525

CPC classification number: C07D295/073 ,  C07D475/00

Abstract: Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.

Abstract translation: 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求和说明书中给出的含义，其异构体，中间体和 制备这些二氢蝶啶酮的方法及其作为药物组合物的用途。

公开(公告)号：US06806272B2

公开(公告)日：2004-10-19

申请号：US10226710

申请日：2002-08-23

Applicant: Eckhart Bauer ,  Steffen Breitfelder ,  Christian Eickmeier ,  Matthias Grauert ,  Matthias Hoffmann ,  Thorsten Lehmann-Lintz ,  Gerald Pohl ,  Jens Quant ,  Norbert Redemann ,  Gisela Schnapp ,  Martin Steegmaier

Inventor： Eckhart Bauer ,  Steffen Breitfelder ,  Christian Eickmeier ,  Matthias Grauert ,  Matthias Hoffmann ,  Thorsten Lehmann-Lintz ,  Gerald Pohl ,  Jens Quant ,  Norbert Redemann ,  Gisela Schnapp ,  Martin Steegmaier

IPC: C07D48704

CPC classification number: C07D487/04 ,  C07D475/00

Abstract: The present invention relates to new dihydropteridinones of the formula (I) wherein the groups X, R1, R2, R3, R4, R5 and R7 have the meanings given in the claims and the specification, the isomers thereof, processes and intermediates for preparing these dihydropteridinones as well as the use thereof as pharmaceutical compositions.

Abstract translation: 本发明涉及式（I）的新的二氢蝶啶酮，其中基团X，R 1，R 2，R 3，R 4，R 5和R 7具有如下含义： 权利要求书和说明书中给出的其异构体，用于制备这些二氢蝶啶烷酮的方法和中间体以及其作为药物组合物的用途。