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    Centrifugal force-based microfluidic device for protein detection and microfluidic system including the same
    32.
    发明授权
    Centrifugal force-based microfluidic device for protein detection and microfluidic system including the same 有权
    用于蛋白质检测和微流体系统的基于离心力的微流体装置包括相同的

    公开(公告)号：US07951333B2

    公开(公告)日：2011-05-31

    申请号：US12851819

    申请日：2010-08-06

    申请人： Beom Seok Lee ,  Yoon Kyoung Cho ,  Jeong Gun Lee ,  Jong-myeon Park

    发明人： Beom Seok Lee ,  Yoon Kyoung Cho ,  Jeong Gun Lee ,  Jong-myeon Park

    IPC分类号： G01N9/30

    CPC分类号： B01L3/502738 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0442 ,  B01L2400/0633 ,  B01L2400/0677 ,  B01L2400/0688 ,  G01N33/54326 ,  G01N33/54366 ,  Y10T436/25375

    摘要： A centrifugal force-based microfluidic device for the detection of a target biomolecule and a microfluidic system including the same are provided. The device includes a body of revolution; a microfluidic structure disposed in the body of revolution including chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structures transmitting fluid using centrifugal force due to rotation of the body of revolution; and beads disposed in the microfluidic structures, the beads having capture probes on the surfaces thereof which are selectively bonded with target protein; and a detection probe disposed in the microfluidic structures and selectively bonded to the target protein, and which includes a material required to express an optical signal, wherein the microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction.

    摘要翻译： 提供了用于检测靶生物分子的离心力微流体装置和包括其的微流体系统。 该装置包括一个革命体; 设置在旋转体中的微流体结构，包括腔室，连接腔室的通道，以及设置在通道中的阀，以控制流体流动，微流体结构由于旋转体旋转而使用离心力传送流体; 和珠子，其设置在微流体结构中，珠粒在其表面上具有与靶蛋白质选择性结合的捕获探针; 以及设置在微流体结构中并选择性地结合到靶蛋白上并且包括表达光信号所需的材料的检测探针，其中微流体结构混合珠，生物样品和检测探针以反应和洗涤和分离 反应后的珠子。

    CENTRIFUGAL FORCE BASED MICROFLUIDIC DEVICE FOR DILUTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME
    34.
    发明申请
    CENTRIFUGAL FORCE BASED MICROFLUIDIC DEVICE FOR DILUTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME 失效
    基于离散力的微流体装置，包括它们的渗透和微流体系统

    公开(公告)号：US20080193336A1

    公开(公告)日：2008-08-14

    申请号：US12029480

    申请日：2008-02-12

    申请人： Yoon-kyoung CHO ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park ,  Young-sun Lee

    发明人： Yoon-kyoung CHO ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park ,  Young-sun Lee

    IPC分类号： B01L11/00

    CPC分类号： B01L3/502738 ,  B01L3/50273 ,  B01L3/502792 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677

    摘要： Provided are a centrifugal force based microfluidic device which can automatically perform a dilution operation and a microfluidic system including the same. The centrifugal force based microfluidic device for dilution includes a rotatable disk type platform, a mixing chamber disposed on the platform; a buffer solution storage disposed on a portion of the platform which is closer to a center of the platform than the mixing chamber, connected to the mixing chamber through a channel to supply a predetermined amount of buffer solution to the mixing chamber at least one time, and a plurality of diluted solution chambers which are disposed on a portion of the platform which is farther from the center of the platform than the mixing chamber, are each connected to the mixing chamber through flow paths extended from a middle exit corresponding to a predetermined water level, and sequentially receiving a solution which is serially diluted in the mixing chamber at least one time.

    摘要翻译： 提供了一种能够自动执行稀释操作的离心力微流体装置和包括其的微流体系统。 用于稀释的基于离心力的微流体装置包括可旋转盘式平台，设置在平台上的混合室; 缓冲溶液储存器，其设置在所述平台的比混合室更靠近所述平台的中心的部分上，所述缓冲溶液存储器经由通道至少一次向所述混合室提供预定量的缓冲溶液，所述通道连接到所述混合室， 并且多个稀释溶液室通过从对应于预定水的中间出口延伸的流路连接到平台的比混合室更远离平台中心的部分上的稀释溶液室 至少一次连续地接收在混合室中连续稀释的溶液。

    CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR NUCLEIC ACID EXTRACTION AND MICROFLUIDIC SYSTEM INCLUDING THE MICROFLUIDIC DEVICE
    35.
    发明申请
    CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR NUCLEIC ACID EXTRACTION AND MICROFLUIDIC SYSTEM INCLUDING THE MICROFLUIDIC DEVICE 有权
    用于核酸提取的基于离心力的微流体装置和包括微流体装置的微流体系统

    公开(公告)号：US20080108120A1

    公开(公告)日：2008-05-08

    申请号：US11848748

    申请日：2007-08-31

    申请人： Yoon-kyoung CHO ,  Jeong-gun LEE ,  Beom-seok LEE ,  Jong-myeon PARK

    发明人： Yoon-kyoung CHO ,  Jeong-gun LEE ,  Beom-seok LEE ,  Jong-myeon PARK

    IPC分类号： C12N13/00 ,  B04B5/10 ,  C12M1/10

    CPC分类号： B01L3/502738 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0076 ,  F16K2099/0084

    摘要： A centrifugal force-based microfluidic device for nucleic acid extraction and a microfluidic system are provided. The microfluidic device includes a body of revolution; a microfluidic structure disposed in the body of revolution, the microfluidic structure including a plurality of chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structure transmitting the fluid using centrifugal force due to rotation of the body of revolution; and magnetic beads contained in one of the chambers which collect a target material from a biomaterial sample flowing into the chamber, wherein the microfluidic structure washes the magnetic beads which collect the target material, and separates nucleic acid by electromagnetic wave irradiation from an external energy source to the magnetic beads. The microfluidic system includes the microfluidic device; a rotation operating unit which rotates the body of revolution; and an external energy source which irradiates electromagnetic waves.

    摘要翻译： 提供了用于核酸提取的离心力微流体装置和微流体系统。 微流体装置包括一个革命体; 设置在旋转体内的微流体结构，所述微流体结构包括多个室，连接所述室的通道和设置在通道中的阀以控制流体流动，所述微流体结构由于所述体的旋转而使用离心力传递流体 的革命 以及包含在其中一个室中的磁珠，其从流入腔室的生物材料样品收集目标材料，其中微流体结构洗涤收集目标材料的磁珠，并通过来自外部能量源的电磁波照射分离核酸 到磁珠。 微流体系统包括微流体装置; 使旋转体旋转的旋转操作单元; 以及照射电磁波的外部能量源。

    Method of concentrating and disrupting cells or viruses
    36.
    发明申请
    Method of concentrating and disrupting cells or viruses 审中-公开
    浓缩和破坏细胞或病毒的方法

    公开(公告)号：US20080090275A1

    公开(公告)日：2008-04-17

    申请号：US11783351

    申请日：2007-04-09

    申请人： Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park ,  Young-sun Lee ,  Hyo-yeon Lee

    发明人： Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park ,  Young-sun Lee ,  Hyo-yeon Lee

    IPC分类号： C12N13/00

    CPC分类号： C12N1/066 ,  C12M47/06 ,  C12N13/00 ,  G01N33/54326

    摘要： Provided is a method for concentrating and disrupting cells or viruses, the method employs magnetic particles which are capable of binding the cells or viruses to capture the cells or viruses and a laser to disrupt the cells or viruses. Since the same particles are used in target cell separation and cell lysis, there is no need to add additional particles in a laser lysis process, and thus integration of a target cell separation, concentration, purification, and nucleic acid extraction process is easy.

    摘要翻译： 提供了一种用于浓缩和破坏细胞或病毒的方法，该方法使用能够结合细胞或病毒以捕获细胞或病毒的磁性颗粒和激光以破坏细胞或病毒。 由于在靶细胞分离和细胞裂解中使用相同的颗粒，因此不需要在激光裂解过程中添加额外的颗粒，因此靶细胞分离，浓缩，纯化和核酸提取过程的整合是容易的。

    Valve unit and apparatus having the same
    39.
    发明授权
    Valve unit and apparatus having the same 有权
    阀门单元和装置具有相同的功能

    公开(公告)号：US08920753B2

    公开(公告)日：2014-12-30

    申请号：US12942279

    申请日：2010-11-09

    申请人： Jong-myeon Park ,  Jeong-gun Lee ,  Yoon-kyoung Cho

    发明人： Jong-myeon Park ,  Jeong-gun Lee ,  Yoon-kyoung Cho

    IPC分类号： B01L3/00 ,  F16K13/10 ,  F16K31/00 ,  F16K31/02 ,  F16K99/00

    CPC分类号： F16K13/10 ,  B01L3/502715 ,  F16K31/002 ,  F16K31/025 ,  F16K99/0001 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0084 ,  Y10T436/2575

    摘要： A valve unit and an apparatus having the same include a plug which includes a phase change material in a solid state at a room temperature and a plurality of fine heat-dissipating particles dispersed in the phase change material. The fine heat-dissipating particles dispersed in the phase change material dissipate heat by absorbing an electromagnetic wave energy generated by electromagnetic wave radiation from the outside and block fluid flow in a path formed by a channel. As an external energy source irradiates an electromagnetic wave on the plug, the plurality of fine heat-dissipating particles dissipate heat and the phase change material becomes molten, thus opening the path to allow the fluid to flow.

    摘要翻译： 阀单元及具有该阀单元的装置包括：塞子，其包括在室温下处于固态的相变材料和分散在相变材料中的多个细散热粒子。 分散在相变材料中的精细散热颗粒通过吸收由外部的电磁波辐射产生的电磁波能量并阻塞由通道形成的路径中的流体流而散发热量。 作为外部能量源，在电源插头上照射电磁波，多个精细的散热粒子散热，相变材料变得熔融，从而打开路径，使流体流动。

    Centrifugal force-based microfluidic device for nucleic acid extraction and microfluidic system including the microfluidic device
    40.
    发明授权
    Centrifugal force-based microfluidic device for nucleic acid extraction and microfluidic system including the microfluidic device 有权
    用于核酸提取的离心力微流体装置和包括微流体装置的微流体系统

    公开(公告)号：US08273310B2

    公开(公告)日：2012-09-25

    申请号：US11848748

    申请日：2007-08-31

    申请人： Yoon-kyoung Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park

    发明人： Yoon-kyoung Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park

    IPC分类号： B04B13/00

    CPC分类号： B01L3/502738 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0076 ,  F16K2099/0084

    摘要： A centrifugal force-based microfluidic device for nucleic acid extraction and a microfluidic system are provided. The microfluidic device includes a body of revolution; a microfluidic structure disposed in the body of revolution, the microfluidic structure including a plurality of chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structure transmitting the fluid using centrifugal force due to rotation of the body of revolution; and magnetic beads contained in one of the chambers which collect a target material from a biomaterial sample flowing into the chamber, wherein the microfluidic structure washes the magnetic beads which collect the target material, and separates nucleic acid by electromagnetic wave irradiation from an external energy source to the magnetic beads. The microfluidic system includes the microfluidic device; a rotation operating unit which rotates the body of revolution; and an external energy source which irradiates electromagnetic waves.

    摘要翻译： 提供了用于核酸提取的离心力微流体装置和微流体系统。 微流体装置包括一个革命体; 设置在旋转体内的微流体结构，所述微流体结构包括多个室，连接所述室的通道和设置在通道中的阀以控制流体流动，所述微流体结构由于所述体的旋转而使用离心力传递流体 的革命 以及包含在其中一个室中的磁珠，其从流入腔室的生物材料样品收集目标材料，其中微流体结构洗涤收集目标材料的磁珠，并通过来自外部能量源的电磁波照射分离核酸 到磁珠。 微流体系统包括微流体装置; 使旋转体旋转的旋转操作单元; 以及照射电磁波的外部能量源。