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    STENT AND MEDICAL DEVICE COMPRISING SAME
    31.
    发明申请
    STENT AND MEDICAL DEVICE COMPRISING SAME 审中-公开

    公开(公告)号：US20200229955A1

    公开(公告)日：2020-07-23

    申请号：US16843422

    申请日：2020-04-08

    申请人： EA Pharma Co., Ltd.

    发明人： Shoji UESUGI ,  Toshiki SAOTOME ,  Atsushi KINUGASA ,  Michito SUMIKAWA ,  Noriko IIJIMA

    IPC分类号： A61F2/90 ,  A61F2/95 ,  B29C53/56 ,  D04C1/02

    摘要： A stent 51c is formed by braiding a plurality of filament threads containing a biodegradable polymer into a cylindrical braid, and connecting points 53a-53d at end portions of the filament threads constituting the braid are arranged in two or more rows in a length direction of the braid. Elastic threads 54a-54d are each disposed outside at least a part of the stent 51c and along at least a part of the stent in the length direction including the vicinity of either one of end portions of the stent. One end of each elastic thread is fixed to the vicinity of the end portion of the stent, and the other end is fixed to any portion of the stent. In a state in which the stent is radially contracted, tension may be applied to the elastic threads. Thus, provided are a stent that is easy to load into a delivery system and also facilitates the expanding operation, as well as a medical device including the stent.

    PRODUCTION METHOD FOR HETEROARYLCARBOXYLIC ACID ESTER DERIVATIVE, PRODUCTION INTERMEDIATE THEREOF, AND CRYSTAL
    38.
    发明申请
    PRODUCTION METHOD FOR HETEROARYLCARBOXYLIC ACID ESTER DERIVATIVE, PRODUCTION INTERMEDIATE THEREOF, AND CRYSTAL 审中-公开
    异氰脲酸酯衍生物的生产方法，其中间产物和晶体

    公开(公告)号：US20160376249A1

    公开(公告)日：2016-12-29

    申请号：US15260730

    申请日：2016-09-09

    申请人： EA PHARMA CO., LTD.

    发明人： Tatsuhiro YAMADA ,  Akinori TATARA ,  Ryuta TAKASHITA ,  Riho KODAMA ,  Kazutaka OOKUMA

    IPC分类号： C07D333/40

    CPC分类号： C07D333/40

    摘要： Compounds of formula (VI), which are useful as therapeutic drugs for diabetes, may be produced by reacting a compound of formula (II) with an acid halogenating agent to give an acid halide; reacting the acid halide with a compound of formula (IV) in the presence of a base, and crystallizing compound (V) or a salt thereof from the reaction system; and subjecting the compound of formula (V) to reductive deprotection in the presence of a metal catalyst, and crystallizing the compound of (VI) or a salt thereof from the reaction system:

    摘要翻译： 提供可用作糖尿病治疗剂，其制备中间体和晶体的化合物（VI）的制备方法。 化合物（VI）或其盐的制备方法包括：使化合物（II）与酸卤化剂反应并转化为酰卤的步骤（d） 在碱的存在下使酰卤与化合物（IV）反应的步骤（e），化合物（V）或其盐从反应体系中结晶; 在化合物（V）在金属催化剂存在下进行还原脱保护反应之后，化合物（VI）或其盐从反应体系（式中， R5表示可以包括取代基的芳烷基，可以包括取代基的芳烷氧基甲基或可以包括取代基的杂芳基烷基。