摘要:
The invention relates to a method for production of compounds of formula (I), where X has the meaning given in claim 1 and precursors for the same.
摘要:
Novel compounds of the formula I in which X, Y, Z, R, R1, R2 and R3 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of tromboembolic diseases and for the treatment of tumors
摘要:
The invention concerns compounds of formula (I),in which R is (i), (ii) or (iii); n is 0, 1 or 2; X means O or S; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have different meanings, or a cyclized tautomeric shape. The invention also concerns the (E) isomers and salts of these compounds which display endothelin receptor antagonistic properties. ##STR1##
摘要:
An automatic, self-adaptive controller for varying the interval between wipes of a windshield wiper arrangement for a vehicle measures current drawn by the windshield wiper arrangement during a forward and return portions of the windshield wiper wipe cycle and calculates an integration of the current over each portion of the windshield wiper wipe cycle to establish forward portion and return portion integration. The magnitude of the portions, which graphically appear as current lobes over time, are indicative of wiper-to-windscreen friction, and hence, wetness. The difference between the forward and return integration is representative of vehicle air speed. The windshield is characterized as wet when the first and second summation values are small, and in that case, a short interval between wipes is established. When the first and second integration values are large, the windshield is deemed to be dry, and a long interval is established between wipes. The windshield wiper system may automatically be turned off when the weather is determined to be dry. When the air speed value is small, the computed interval is not changed. However, when the air speed value is large, the interval is reduced in duration. The invention contemplates the development of parameters for specific vehicle types and models whereby a cost saving is achieved by using the same control system.
摘要:
Alkylbenzoylguanidines of the formula I ##STR1## in which A, R.sup.1, R.sup.2 and R.sup.3 have the given meanings, and their physiologically harmless salts exhibit antiarrhythmic properties and act as inhibitor of the cellular Na.sup.+ /H.sup.+ antiporter.
摘要翻译:其中A,R 1,R 2和R 3具有给定含义的式I的烷基苯甲酰胍,以及它们的生理无害盐表现出抗心律失常性质,并且作为细胞Na + / H +反转录酶的抑制剂。
摘要:
Fluorine-containing benzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 have the meanings indicated, and their physiologically acceptable salts, have antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter, for example.
摘要翻译:其中R 1,R 2和R 3具有所示含义的式I的含氟苯甲酰胍及其生理上可接受的盐具有抗心律失常性质,并且作为细胞Na + / H +反向转运体的抑制剂。
摘要:
Novel compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, --A.dbd.B--C.dbd.D--, Ar and X have the meaning indicated in claim 1, and their salts show endothelin receptor-antagonistic properties.
摘要:
Novel imidazopyridine derivatives of the formula ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, Ar.sup.1, X and Y are as defined in the specification, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
摘要:
Novel imidazopyridine derivatives of formula I: ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.