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公开(公告)号:US20100021378A1
公开(公告)日:2010-01-28
申请号:US12309479
申请日:2007-07-19
Applicant: Benny Rousso , Dalia Dickman , Shlomo Ben-Haim , Simona Ben Haim
Inventor: Benny Rousso , Dalia Dickman , Shlomo Ben-Haim , Simona Ben Haim
IPC: A61K51/00
CPC classification number: A61B6/4057 , A61B5/4064 , A61B5/4076 , A61B5/411 , A61B5/415 , A61B5/417 , A61B5/418 , A61B6/037 , A61B6/4258 , A61B6/4488 , A61B6/501 , A61B6/502 , A61B6/503 , A61B6/504 , A61B6/583 , A61B8/0891
Abstract: Protocols for radioimaging an event or disorder are provided. An exemplary protocol comprises a method of radioimaging a myocardial perfusion, the method comprising in sequence: (a) administering to a subject about 3 mCi Tl201 thallous chloride; (b) allowing said subject to rest; (c) radioimaging a heart of said subject; (d) subjecting said subject to a physical stress; (e) administering to said subject at a peak of said physical stress about 20-30 mCi Tc99m sestamibi; and (f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.
Abstract translation: 提供用于放射成像事件或障碍的协议。 示例性方案包括放射成像心肌灌注的方法,该方法依次包括:(a)向受试者施用约3mCi Tl201硫酸氯化物; (b)允许所述受试者休息; (c)对所述受试者的心脏进行放射成像; (d)使所述受试者受到身体压力; (e)在所述身体应激的峰值处施用约20-30mCi Tc99m sestamibi的所述受试者; 和(f)对所述受试者的所述心脏进行放射成像,从而放射成像心肌灌注。
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公开(公告)号:US20090201291A1
公开(公告)日:2009-08-13
申请号:US12087150
申请日:2006-12-28
Applicant: Omer Ziv , Ran Ravhon , Eli Dichterman , Leonid Gluhovsky , Shiomo Ben-Haim , Benny Rousso
Inventor: Omer Ziv , Ran Ravhon , Eli Dichterman , Leonid Gluhovsky , Shiomo Ben-Haim , Benny Rousso
CPC classification number: G01T1/1644 , A61B5/055 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/7285 , A61B6/037 , A61B6/503 , A61B6/541 , A61B8/0883 , A61B8/543 , G01T1/1663 , G06T11/005 , G06T11/006 , G06T11/008 , G06T2207/10104 , G06T2207/30048 , G06T2211/436
Abstract: A method for reconstructing a radioactive emission image of an overall volume having first and second volumetric regions, each volumetric region having respectively independent dynamic characteristics. The method comprises the following steps: a) obtaining radioactive emissions from the overall volume, including the volumetric regions, b) reconstructing an initial radioactive emission image of the volumetric region according to the radioactive emissions, c) segmenting the initial radioactive emission image to delineate the first and second volumetric regions, and d) separately reconstructing the first and the second volumetric regions according to the respectively independent dynamic characteristics.
Abstract translation: 一种用于重建具有第一和第二体积区域的总体积的放射性发射图像的方法,每个体积区域具有分别独立的动态特性。 该方法包括以下步骤:a)从总体积(包括体积区域)获得放射性发射,b)根据放射性发射重建体积区域的初始放射性发射图像,c)分割初始放射性发射图像以描绘 第一和第二体积区域,以及d)根据分别独立的动态特性分别重建第一和第二体积区域。
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公开(公告)号:US07402813B2
公开(公告)日:2008-07-22
申请号:US11610196
申请日:2006-12-13
Applicant: Shlomo Ben-Haim , Benny Rousso , Shahram Moaddeb
Inventor: Shlomo Ben-Haim , Benny Rousso , Shahram Moaddeb
IPC: G01T1/24
CPC classification number: G01T1/1648 , G01T1/249
Abstract: A gamma ray camera system is provided, which includes a lens system comprising at least one crystal diffraction lens, and a camera. The camera is configured to perform gamma ray imaging of a first region of a volume of interest using the lens system, and perform gamma ray imaging of a second region of the volume of interest without using the lens system. Other embodiments are also described.
Abstract translation: 提供了一种伽马射线照相机系统,其包括包括至少一个晶体衍射透镜的透镜系统和照相机。 相机被配置为使用透镜系统对感兴趣体积的第一区域进行伽马射线成像,并且在不使用透镜系统的情况下执行感兴趣体积的第二区域的伽马射线成像。 还描述了其它实施例。
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公开(公告)号:US20080128626A1
公开(公告)日:2008-06-05
申请号:US11980653
申请日:2007-10-31
Applicant: Benny Rousso , Shlomo Ben-Haim , Michael Nagler , Omer Ziv , Ran Ravhon , Dalia Dickman , Yoel Zilberstein , Eli Dichterman , Simona Ben-Haim , Shankar Vallabhajosula , Daniel Berman , Zohar Bronshtine , Ziv Popper , Nir Weissberg , Nathaniel Roth , Haim Melman
Inventor: Benny Rousso , Shlomo Ben-Haim , Michael Nagler , Omer Ziv , Ran Ravhon , Dalia Dickman , Yoel Zilberstein , Eli Dichterman , Simona Ben-Haim , Shankar Vallabhajosula , Daniel Berman , Zohar Bronshtine , Ziv Popper , Nir Weissberg , Nathaniel Roth , Haim Melman
IPC: G01T1/166
CPC classification number: A61B6/44 , A61B5/06 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/7285 , A61B6/037 , A61B6/0414 , A61B6/425 , A61B6/4258 , A61B6/4266 , A61B6/4275 , A61B6/4291 , A61B6/488 , A61B6/501 , A61B6/502 , A61B6/507 , A61B6/541 , A61B6/547 , A61B6/548 , A61B6/583 , A61B8/0808 , A61B8/0825 , A61B8/12 , A61B8/4416 , A61B8/543 , A61K51/00 , A61K51/0478 , A61K51/1048 , G01R33/481 , G01T1/1615 , G01T1/1642 , G01T1/2985
Abstract: Radioimaging methods, devices and radiopharmaceuticals therefor.
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公开(公告)号:US20070194241A1
公开(公告)日:2007-08-23
申请号:US11656548
申请日:2007-01-23
Applicant: Benny Rousso , Michael Nagler
Inventor: Benny Rousso , Michael Nagler
IPC: G01T1/20
CPC classification number: A61B6/481 , A61B6/4057 , A61B6/4258 , A61B6/486 , A61B6/5217 , A61B6/5241 , A61B90/39 , A61M5/007 , G01T1/161 , G01T1/166
Abstract: Apparatus for radiation based imaging of a non-homogenous target area having distinguishable regions therein, comprises: an imaging unit configured to obtain radiation intensity data from a target region in the spatial dimensions and at least one other dimension, and an image four-dimension analysis unit analyzes the intensity data in the spatial dimension and said at least one other dimension in order to map the distinguishable regions. The system typically detects rates of change over time in signals from radiopharmaceuticals and uses the rates of change to identify the tissues. In a preferred embodiment, two or more radiopharmaceuticals are used, the results of one being used as a constraint on the other.
Abstract translation: 用于其中具有可区分区域的非均匀目标区域的用于基于辐射的成像的装置包括:成像单元,被配置为从空间维度和至少一个其他维度中的目标区域获得辐射强度数据,以及图像四维分析 单元分析空间维度中的强度数据和所述至少一个其他维度,以便映射可区分的区域。 该系统通常检测来自放射性药物的信号随时间的变化率,并使用变化率来识别组织。 在优选实施方案中,使用两种或更多种放射性药物,一种用于另一种放射性药物的结果。
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公开(公告)号:US20170039738A1
公开(公告)日:2017-02-09
申请号:US15294737
申请日:2016-10-16
Applicant: Spectrum Dynamics LLC
Inventor: Omer ZIV , Ran RAVHON , Eli DICHTERMAN , Leonid GLUHOVSKY , Shlomo BEN-HAIM , Benny ROUSSO
IPC: G06T11/00 , G06T7/60 , A61B6/03 , A61B5/00 , G01T1/164 , A61B5/055 , A61B8/13 , A61B8/08 , G06T7/00 , A61B6/00
CPC classification number: G06T11/006 , A61B5/055 , A61B5/7289 , A61B6/032 , A61B6/037 , A61B6/503 , A61B6/5288 , A61B8/13 , A61B8/5284 , G01T1/161 , G01T1/1644 , G01T1/243 , G01T1/247 , G01T1/249 , G06T7/0012 , G06T7/62 , G06T2207/10088 , G06T2207/10108 , G06T2207/10116 , G06T2207/10132 , G06T2207/10136 , G06T2207/30048
Abstract: A method for reconstructing a radioactive emission image of an overall volume having first and second volumetric regions, each volumetric region having respectively independent dynamic characteristics. The method comprises the following steps: a) obtaining radioactive emissions from the overall volume, including the volumetric regions, b) reconstructing an initial radioactive emission image of the volumetric region according to the radioactive emissions, c) segmenting the initial radioactive emission image to delineate the first and second volumetric regions, and d) separately reconstructing the first and the second volumetric regions according to the respectively independent dynamic characteristics.
Abstract translation: 一种用于重建具有第一和第二体积区域的总体积的放射性发射图像的方法,每个体积区域具有分别独立的动态特性。 该方法包括以下步骤:a)从总体积(包括体积区域)获得放射性发射,b)根据放射性发射重建体积区域的初始放射性发射图像,c)分割初始放射性发射图像以描绘 第一和第二体积区域,以及d)根据分别独立的动态特性分别重建第一和第二体积区域。
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公开(公告)号:US20160253826A9
公开(公告)日:2016-09-01
申请号:US12087150
申请日:2006-12-28
Applicant: Omer Ziv , Ran Ravhon , Eli Dichterman , Leonid Gluhovsky , Shiomo Ben-Haim , Benny Rousso
Inventor: Omer Ziv , Ran Ravhon , Eli Dichterman , Leonid Gluhovsky , Shiomo Ben-Haim , Benny Rousso
CPC classification number: G01T1/1644 , A61B5/055 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/7285 , A61B6/037 , A61B6/503 , A61B6/541 , A61B8/0883 , A61B8/543 , G01T1/1663 , G06T11/005 , G06T11/006 , G06T11/008 , G06T2207/10104 , G06T2207/30048 , G06T2211/436
Abstract: A method for reconstructing a radioactive emission image of an overall volume having first and second volumetric regions, each volumetric region having respectively independent dynamic characteristics. The method comprises the following steps: a) obtaining radioactive emissions from the overall volume, including the volumetric regions, b) reconstructing an initial radioactive emission image of the volumetric region according to the radioactive emissions, c) segmenting the initial radioactive emission image to delineate the first and second volumetric regions, and d) separately reconstructing the first and the second volumetric regions according to the respectively independent dynamic characteristics.
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公开(公告)号:US08894974B2
公开(公告)日:2014-11-25
申请号:US11747378
申请日:2007-05-11
Applicant: Benny Rousso , Chalom Bruno Sayada
Inventor: Benny Rousso , Chalom Bruno Sayada
CPC classification number: A61K31/66 , A61K49/0004 , A61K51/00
Abstract: A method for treating a human patient is provided, including administering a radiolabeled form of a therapeutic agent to the patient at a first substantially non-therapeutically-effective dose, wherein pharmacological activity of the therapeutic agent is not due to radioactivity of the therapeutic agent. The method also includes determining information related to a biodistribution of the radiolabeled form of the therapeutic agent in the patient by performing a radioimaging procedure on the patient. Responsively to the information, a decision is made whether or not to treat the patient by administering the therapeutic agent to the patient. If the decision is made to treat the patient, the patient is treated by administering the therapeutic agent to the patient at a second therapeutically-effective dose. If the decision is made not to treat the patient, treatment of the patient with the therapeutic agent is withheld. Other embodiments are also described.
Abstract translation: 提供了一种治疗人类患者的方法,包括以第一基本上非治疗有效的剂量向患者施用放射标记形式的治疗剂,其中治疗剂的药理学活性不是由于治疗剂的放射性。 该方法还包括通过对患者执行放射成像过程来确定与患者的放射标记形式的治疗剂的生物分布有关的信息。 响应于该信息,决定是否通过向患者施用治疗剂来治疗患者。 如果决定治疗患者,则通过以第二治疗有效剂量向患者施用治疗剂来治疗患者。 如果决定不对待病人,则禁止用治疗剂治疗患者。 还描述了其它实施例。
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公开(公告)号:US08586932B2
公开(公告)日:2013-11-19
申请号:US11798017
申请日:2007-05-09
Applicant: Benny Rousso , Shlomo Ben-Haim , Michael Nagler , Omer Ziv , Ran Ravhon , Dalia Dickman , Yoel Zilberstein , Eli Dichterman , Simona Ben-Haim , Shankar Vallabhajosula , Daniel Berman , Zohar Bronshtine , Ziv Popper , Nir Weissberg , Nathaniel Roth , Haim Melman
Inventor: Benny Rousso , Shlomo Ben-Haim , Michael Nagler , Omer Ziv , Ran Ravhon , Dalia Dickman , Yoel Zilberstein , Eli Dichterman , Simona Ben-Haim , Shankar Vallabhajosula , Daniel Berman , Zohar Bronshtine , Ziv Popper , Nir Weissberg , Nathaniel Roth , Haim Melman
CPC classification number: G01T1/1642 , A61B5/4064 , A61B5/4076 , A61B5/417 , A61B6/037 , A61B6/4258 , G01T1/1603 , G01T1/161 , G01T1/1648 , G06F19/00
Abstract: A method of radioactive-emission-measurement. The method comprises providing a camera for the detection of single emissions, which defines proximal and distal ends. The camera is configured for enabling a reconstruction of a volumetric image having a line spread function of less than 7 mm Full Width Half Maximum (FWHM) when given a substantially line source of radioactive emission, with an activity of 5 mCi, within a region-of-interest volume, at a distance of at least 100 mm from said distal end, with air being substantially the only operating medium. The method further comprises detecting at least 1 of every 5000 photons, emitted from at least one radioactive-emission source, located within a certain region-of-interest volume, using the camera, and reconstructing a volumetric radioactive-emission image from the detected photons.
Abstract translation: 一种放射性发射测量方法。 该方法包括提供用于检测限定近端和远端的单个排放物的照相机。 相机被配置为使得能够重建具有小于7mm全宽度最大值(FWHM)的线扩展功能的体积图像,当给定基本上线性的放射性发射源时,具有5mCi的活动, 在距离所述远端至少100mm的距离处,空气基本上是唯一的操作介质。 该方法还包括使用相机检测位于一定感兴趣区域内的至少一个放射性发射源发射的每5000个光子中的至少1个,以及从检测到的光子重构体积放射性发射图像 。
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公开(公告)号:US08527294B2
公开(公告)日:2013-09-03
申请号:US11750057
申请日:2007-05-17
Applicant: Benny Rousso , Shlomo Ben-Haim , Haim Melman , Zohar Bronshtine , Yoel Zilberstien , Michael Nagler , Dalia Dickman , Einav Omer
Inventor: Benny Rousso , Shlomo Ben-Haim , Haim Melman , Zohar Bronshtine , Yoel Zilberstien , Michael Nagler , Dalia Dickman , Einav Omer
IPC: G06Q10/00
Abstract: Apparatus is provided for use with at least one labeled radiopharmaceutical agent, the apparatus including a container (22) containing the at least one labeled radiopharmaceutical agent, and a portable computer-communicatable data carrier (120, 24) associated with the container (22), the data carrier (120, 24) containing imaging protocol information for use with the at least one labeled radiopharmaceutical agent. Other embodiments are also described.
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