公开(公告)号：US10550141B2

公开(公告)日：2020-02-04

申请号：US16089730

申请日：2017-03-30

申请人： TAKASAGO INTERNATIONAL CORPORATION

发明人： Yuji Nakayama ,  Naota Yokoyama

IPC分类号： C07F15/00 ,  B01J31/22 ,  C07D263/22 ,  C07B53/00 ,  C07D263/38 ,  C07F9/50 ,  C07F15/02 ,  C07C319/14 ,  C07C323/25 ,  C07C323/29

摘要： The present invention relates to: a compound as a ligand in a variety of catalytic organic synthetic reactions; a method for producing the compound; a synthetic intermediate of the compound; and a transition metal complex which has the compound as a ligand. The compound includes a compound represented by the following general formula (1A):

公开(公告)号：US20200031855A1

公开(公告)日：2020-01-30

申请号：US16595069

申请日：2019-10-07

申请人： The Board of Regents of the Nevada System of Higher Education on Behalf of the University of Nevada

发明人： Jun Yong Kang ,  Hai Huang ,  Nagaraju Molleti

IPC分类号： C07F9/6584 ,  C07F9/53 ,  C07F9/50 ,  C07D403/04

摘要： Provided herein are functionalized phosphonates and methods for making same via phosphite addition to an atom alpha to an electron withdrawing group. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20190382423A1

公开(公告)日：2019-12-19

申请号：US15750480

申请日：2017-11-20

申请人： Jubilant Generics Limited (Formerly a division of Jubilant Life Sciences Limited)

发明人： Mokkapati Umamaheshwar PRASAD ,  Anjul KUMAR ,  Shishupal SINGH ,  Dharam VIR

IPC分类号： C07F9/50

摘要： The present invention relates to an improved process for the preparation of tetrofosmin or acid addition salt thereof. The present invention also relates to the process for the preparation of tetrofosmin disulfosalicylate salt. Further the present invention also provides the polymorphic form J of disulfosalicylate salt of tetrofosmin.

公开(公告)号：US20190381489A1

公开(公告)日：2019-12-19

申请号：US16480082

申请日：2018-02-21

申请人： KURARAY CO., LTD.

发明人： Yusaku HOSAKA

IPC分类号： B01J31/24 ,  B01J31/22 ,  B01J37/04 ,  C07C27/10 ,  C07F9/50

摘要： There is provided a method for producing a catalyst liquid containing a Group 6 to 11 transition metal catalyst in which the transition metal catalyst can be prevented from being blackened during storage, the method including performing addition of an alkenyl compound and addition of a phosphorus ligand, and then performing addition of a Group 6 to 11 transition metal catalyst

公开(公告)号：US10428096B2

公开(公告)日：2019-10-01

申请号：US14906233

申请日：2014-07-16

申请人： HYOSUNG CHEMICAL CORPORATION ,  ST PHARM CO., LTD.

发明人： Jae Yoon Shim ,  Sun Kue Kim ,  Hae Souk Cho ,  Ji Hwan Choi ,  Geun Jho Lim ,  Sun Ki Chang ,  Min Kyu Kim ,  In Hyeok Baek

IPC分类号： C07F9/00 ,  C07F9/655 ,  C07F9/50 ,  C08G67/02

摘要： Provided are a novel polyketone polymerization catalyst and a method of preparing a ligand, which can reduce production costs and can enable commercial mass synthesis by using ((2,2-dimethyl-1,3-dioxane-5,5-diyl)bis(methylene))bis(bis(2-methoxyphenyl)phosphine) as a ligand constituting the polykeytone polymerization catalyst, the ligand having a simple structure and a small molecular weight while having high activity.

公开(公告)号：US10413893B2

公开(公告)日：2019-09-17

申请号：US15517758

申请日：2016-02-02

申请人： LG CHEM, LTD.

发明人： Eun Ji Shin ,  Yong Ho Lee ,  Seul Ki Im ,  Ki Soo Lee ,  Jin Young Park ,  Seok Pil Sa

IPC分类号： C07C2/02 ,  C07C2/04 ,  C07C2/24 ,  C07C2/26 ,  B01J31/24 ,  B01J31/02 ,  B01J31/04 ,  B01J31/14 ,  C07C2/32 ,  C08F210/16 ,  C08F2/40 ,  C08F4/69 ,  C08F10/00 ,  C08K5/05 ,  B01J31/18 ,  C07F9/50 ,  C08K5/00 ,  C08K5/17 ,  B01J35/00 ,  B01J37/04 ,  C08F10/02

摘要： The method for oligomerizing olefin according to the present disclosure is a method for oligomerizing olefin using an oligomerization catalyst system and includes deteriorating the activity of the oligomerization catalyst system by injecting a deactivator in a latter part of a multimerization reaction of olefin. The deactivator may include an additive for polymer containing at least one functional group selected from the group consisting of a hydroxyl group, an amine group and an amide group. According to the oligomerizing method, the isomer of 1-hexene and/or 1-octene and alpha-olefins with C10 to C40 may be decreased via the restraint of the additional side reaction of a product. Since the deactivator is an additive for enhancing the physical properties of a polymer, a separating process thereof is not required, thereby improving economic feasibility and productivity.

公开(公告)号：US10266621B2

公开(公告)日：2019-04-23

申请号：US15510608

申请日：2015-09-10

申请人： Council of Scientific and Industrial Research

发明人： Samir Hujur Chikkali ,  Shahaji Rajaram Gaikwad

IPC分类号： C08F10/02 ,  C07F9/50 ,  C07F15/00

摘要： The present invention discloses nitrile ligated transition metal-phosphinobenzene-sulfonate complex of formula (I) as catalyst for insertion-copolymerization of mono and bis functionalized vinyl monomers with ethylene or other olefins. In particular, the present invention discloses nitrile ligated metal-phosphinobenzene-sulfonate complex of formula (I) as catalyst for insertion-copolymerization of mono and bis functionalized vinyl monomers with ethylene and or other olefins and to the process for preparation thereof. The invention further discloses a process for the insertion-(co)polymerization of mono and bis functionalized vinyl monomers with olefms catalyzed by the catalyst of formula (I).

公开(公告)号：US20190040089A1

公开(公告)日：2019-02-07

申请号：US16112426

申请日：2018-08-24

申请人： KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS ,  KING SAUD UNIVERSITY

发明人： Said S. AL-JAROUDI ,  Ali ALHOSHANI ,  Muhammad ALTAF ,  Anvarhusein Abdulkadir ISAB

IPC分类号： C07F9/50 ,  A61N1/30 ,  A61K9/00 ,  A61K45/06 ,  A61K31/66 ,  C12Q1/6886 ,  G01N33/574

摘要： Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.

公开(公告)号：US20180362557A1

公开(公告)日：2018-12-20

申请号：US16112358

申请日：2018-08-24

申请人： KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS ,  KING SAUD UNIVERSITY

发明人： Said S. Al-Jaroudi ,  Ali Alhoshani ,  Muhammad Altaf ,  Anvarhusein Abdulkadir Isab

IPC分类号： C07F9/50 ,  A61K31/66 ,  A61K9/00 ,  G01N33/574 ,  C12Q1/6886 ,  A61K45/06

CPC分类号： C07F9/5045 ,  A61K9/0053 ,  A61K31/66 ,  A61K45/06 ,  A61N1/30 ,  C12Q1/6886 ,  C12Q2600/156 ,  G01N33/57415 ,  G01N2800/52

摘要： Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.

公开(公告)号：US20180361369A1

公开(公告)日：2018-12-20

申请号：US15781334

申请日：2016-11-11

申请人： ST PHARM CO., LTD.

发明人： Geun Jho Lim ,  Sun Ki Chang ,  Hyun Woo Baek ,  Jun Hyun Oh ,  Yeong Hun Kim

IPC分类号： B01J31/02 ,  C07F9/50

摘要： The present disclosure provides a method for preparing ((2,2-dimethyl-1,3-dioxane-5,5-diyl)bis(methylene))bis(bis(2-methoxyphenyl)phosphine), a ligand for a polyketone polymerization catalyst, under mild conditions with high purity and high yield. Therefore, the preparation method of the present disclosure can be easily applied to mass production.