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公开(公告)号：US10428096B2
公开(公告)日：2019-10-01
申请号：US14906233
申请日：2014-07-16
发明人： Jae Yoon Shim , Sun Kue Kim , Hae Souk Cho , Ji Hwan Choi , Geun Jho Lim , Sun Ki Chang , Min Kyu Kim , In Hyeok Baek
摘要： Provided are a novel polyketone polymerization catalyst and a method of preparing a ligand, which can reduce production costs and can enable commercial mass synthesis by using ((2,2-dimethyl-1,3-dioxane-5,5-diyl)bis(methylene))bis(bis(2-methoxyphenyl)phosphine) as a ligand constituting the polykeytone polymerization catalyst, the ligand having a simple structure and a small molecular weight while having high activity.
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公开(公告)号：US10538504B2
公开(公告)日：2020-01-21
申请号：US16060655
申请日：2016-12-09
申请人： ST PHARM CO., LTD.
发明人： Seok Hun Woo , YunHee Choi , Hong Jun Kim , Sun Ki Chang , Geun Jho Lim
IPC分类号： C07D401/04
摘要： Disclosed is a method of preparing an intermediate for an oxazolidinone derivative, which enables 5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine to be produced at high yield and high purity, thus exhibiting high preparation efficiency under optimal processing conditions and making it suitable for industrial mass production.
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公开(公告)号：US10702859B2
公开(公告)日：2020-07-07
申请号：US15781334
申请日：2016-11-11
申请人： ST PHARM CO., LTD.
发明人： Geun Jho Lim , Sun Ki Chang , Hyun Woo Baek , Jun Hyun Oh , Yeong Hun Kim
摘要： The present disclosure provides a method for preparing ((2,2-dimethyl-1,3-dioxane-5,5-diyl)bis(methylene))bis(bis(2-methoxyphenyl)phosphine), a ligand for a polyketone polymerization catalyst, under mild conditions with high purity and high yield. Therefore, the preparation method of the present disclosure can be easily applied to mass production.
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公开(公告)号：US10065933B2
公开(公告)日：2018-09-04
申请号：US15528281
申请日：2015-12-28
申请人： ST PHARM CO., LTD.
发明人： Geun Jho Lim , Sun Ki Chang , Chang Ho Byeon , Hoe Jin Yoon , Moon Soo Kim
IPC分类号： C07D257/02 , C07F5/00 , A61K49/10
摘要： The present disclosure relates to a novel method for preparing high-purity gadobutrol. The present disclosure can be easily applied to a large scale production because purity of intermediate can be managed via simple and mild process and accordingly, high-purity or ultra high-purity gadobutrol that has higher purity than previous gadobutrol can be prepared in high yield therethrough.
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公开(公告)号：US09822084B2
公开(公告)日：2017-11-21
申请号：US15511882
申请日：2015-09-07
申请人： ST PHARM CO., LTD.
发明人： Geun Jho Lim , Sun Ki Chang , Chang Ho Byeon , Hoe Jin Yoon , Moon Soo Kim
IPC分类号： C07D257/02
CPC分类号： C07D257/02 , C07F3/04
摘要： Disclosed is a novel method of preparing highly pure calcobutrol using an intermediate (butrol) of gadobutrol without using highly pure gadobutrol. This method is capable of obtaining calcobutrol at high purity and high yield through a simple and environmentally friendly process, and thus can be easily applied to mass production.
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公开(公告)号：US20180361369A1
公开(公告)日：2018-12-20
申请号：US15781334
申请日：2016-11-11
申请人： ST PHARM CO., LTD.
发明人： Geun Jho Lim , Sun Ki Chang , Hyun Woo Baek , Jun Hyun Oh , Yeong Hun Kim
摘要： The present disclosure provides a method for preparing ((2,2-dimethyl-1,3-dioxane-5,5-diyl)bis(methylene))bis(bis(2-methoxyphenyl)phosphine), a ligand for a polyketone polymerization catalyst, under mild conditions with high purity and high yield. Therefore, the preparation method of the present disclosure can be easily applied to mass production.
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公开(公告)号：US20180346443A1
公开(公告)日：2018-12-06
申请号：US16060655
申请日：2016-12-09
申请人： ST PHARM CO., LTD.
发明人： Seok Hun Woo , YunHee Choi , Hong Jun Kim , Sun Ki Chang , Geun Jho Lim
IPC分类号： C07D401/04
摘要： Disclosed is a method of preparing an intermediate for an oxazolidinone derivative, which enables 5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine to be produced at high yield and high purity, thus exhibiting high preparation efficiency under optimal processing conditions and making it suitable for industrial mass production.
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公开(公告)号：US09790170B2
公开(公告)日：2017-10-17
申请号：US15034536
申请日：2014-10-27
申请人： ST PHARM CO., LTD.
发明人： Geun Jho Lim , Sun Ki Chang , Jae Hun Kim , Jong Moon Park
IPC分类号： C07C231/12 , C07C231/02 , B01J23/04
CPC分类号： C07C231/12 , B01J23/04 , C07C231/02 , C07C233/47 , C07C237/22
摘要： The present invention provides a novel method for preparing lacosamide with high chiral purity from D-serine. The method of the present invention can obtain lacosamide with high chiral purity in a high yield through a simple and environmentally-friendly process and thus can be easily applied to mass production.
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