-
公开(公告)号：US20100216969A1
公开(公告)日：2010-08-26
申请号：US11993168
申请日：2006-06-27
CPC分类号： G01N33/54353 , C07K17/06
摘要： The present invention relates generally to methods and carriers for cross-linking or immobilising biomolecules such as polypeptides. In particular, the present invention relates to methods and carriers useful for coupling a polypeptide to a carrier via at least one disulphide bond. The carrier coupled to the biomolecules has applications in the fields of e.g. molecular biology, biochemistry, pharmacology, and medical diagnostic technology.
摘要翻译： 本发明一般涉及用于交联或固定生物分子如多肽的方法和载体。 特别地，本发明涉及用于通过至少一个二硫键将多肽偶联到载体上的方法和载体。 偶联到生物分子的载体具有例如以下领域的应用。 分子生物学，生物化学，药理学和医学诊断技术。
-
公开(公告)号：US20100209390A1
公开(公告)日：2010-08-19
申请号：US12708671
申请日：2010-02-19
申请人： Yat Sun Or , Guoqiang Wang , Xuri Gao , Jiang Long
发明人： Yat Sun Or , Guoqiang Wang , Xuri Gao , Jiang Long
摘要： The present invention provides cyclosporin analogues of formula I, and compositions comprising these compounds, as well as processes for their preparation, intermediates in their synthesis, and methods of use thereof for prevention of organ transplantation rejection, the treatment of immune disorders and inflammation, and treatment of viral (particularly hepatitis C viral) infection.
摘要翻译： 本发明提供式I的环孢菌素类似物，以及包含这些化合物的组合物，及其制备方法，其合成中的中间体及其用于预防器官移植排斥反应，免疫疾病和炎症的治疗的方法和 治疗病毒（特别是丙型肝炎病毒）感染。
-
公开(公告)号：US20100120670A1
公开(公告)日：2010-05-13
申请号：US12297110
申请日：2007-04-03
申请人： Richard Clark , David James Craik
发明人： Richard Clark , David James Craik
摘要： This invention relates to an oral or enteral pharmaceutical preparation comprising at least one synthetically cyclised alpha-conotoxin peptide having an amide cyclised backbone such that the peptide has no free N- or C-terminus, said peptide having the ability to inhibit a nicotinic acetylcholine receptor and comprising four cysteine residues bonded in pairs to form two disulfide bonds, wherein the N-terminus of the corresponding linear/non-cyclised conotoxin peptide is linked to the C-terminus by a peptide linker, in a vehicle which is pharmaceutically suitable for oral or enteral administration.
摘要翻译： 本发明涉及口服或肠内药物制剂，其包含至少一种具有酰胺环化主链的合成环化的α-芋螺毒素肽，使得肽不具有游离的N-或C-末端，所述肽具有抑制烟碱乙酰胆碱受体的能力 并且包含成对结合以形成两个二硫键的四个半胱氨酸残基，其中相应的线性/非环化的芋螺毒素肽的N-末端通过肽接头在C末端连接，其药学上适用于口服 或肠内管理。
-
公开(公告)号：US20100081611A1
公开(公告)日：2010-04-01
申请号：US12478504
申请日：2009-06-04
摘要： Stably cross-linked a polypeptides related to human MAML are described. These cross-linked polypeptides contain at least two modified amino acids that together form an internal cross-link or tether that can help to stabilize the alpha-helical secondary structure that is thought to be important for binding of MAML peptides to the Notch transcription complex, a complex that includes ICN and CSL.
摘要翻译： 描述了稳定交联的与人MAML相关的多肽。 这些交联的多肽含有至少两个修饰的氨基酸，它们一起形成可以有助于稳定被认为对MAML肽与Notch转录复合物的结合重要的α-螺旋二级结构的内部交联或系链， 一个包含ICN和CSL的复合体。
-
公开(公告)号：US20090082259A1
公开(公告)日：2009-03-26
申请号：US12196914
申请日：2008-08-22
申请人： Anthony W. Czarnik
发明人： Anthony W. Czarnik
CPC分类号： A61K38/12
摘要： The present application describes deuterium-enriched octreotide, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
摘要翻译： 本申请描述了富含氘的奥曲肽，其药学上可接受的盐形式，以及使用其的治疗方法。
-
公开(公告)号：US20080279771A1
公开(公告)日：2008-11-13
申请号：US12091804
申请日：2006-10-30
CPC分类号： A61K51/088 , A61K49/0002 , A61K51/08
摘要： A novel imaging agent is described which comprises a semaphorin moiety and an imaging moiety. The novel imaging agent of the invention may be used in the diagnostic imaging of cancer and in particular, for targeting angiogenesis or metaplasia. Further aspects of the present invention presented herein include a method for the preparation of the imaging agent, a pharmaceutical composition comprising the imaging agent of the invention and a kit for the preparation of said pharmaceutical.
摘要翻译： 描述了一种包含信号素部分和成像部分的新型成像剂。 本发明的新型成像剂可用于癌症的诊断成像，特别是用于靶向血管生成或化生。 本文提供的本发明的其它方面包括制备显像剂的方法，包含本发明的成像剂的药物组合物和用于制备所述药物的试剂盒。
-
公开(公告)号：US20080247999A1
公开(公告)日：2008-10-09
申请号：US11570743
申请日：2005-06-14
IPC分类号： A61K35/12 , C07K2/00 , C07K7/06 , C07K7/50 , C07K14/00 , A61K38/02 , C12Q1/18 , A61K38/08 , A61K38/12 , A61K38/16 , A61P35/00
CPC分类号： C12N9/1205 , G01N33/5011 , G01N2333/9121
摘要： The present invention provides a peptide comprising an amino acid sequence that is part of the amino acid sequence of CDK4 protein, or homologous to part of the amino acid sequence of CDK4 protein, which peptide is cytotoxic to, and/or inhibiting to the growth of, a cancer cell and/or stimulating to the growth of a non-cancerous cell and/or a control cell. Methods of identifying such peptides and medical uses of such peptides are also disclosed.
摘要翻译： 本发明提供了一种肽，其包含作为CDK4蛋白的氨基酸序列的一部分的氨基酸序列，或与CDK4蛋白的氨基酸序列的一部分同源的肽，该肽是细胞毒性的和/或抑制的 ，癌细胞和/或刺激非癌细胞和/或对照细胞的生长。 还公开了鉴定这些肽的方法和这种肽的医疗用途。
-
公开(公告)号：US07351791B2
公开(公告)日：2008-04-01
申请号：US11405234
申请日：2006-04-17
申请人： Martin S. Linsell
发明人： Martin S. Linsell
IPC分类号： C07K7/50
摘要： This invention provides 9-fluorenylmethoxycarbonyl compounds that are useful as intermediates for preparing glycopeptide antibiotics.
摘要翻译： 本发明提供了可用作制备糖肽抗生素的中间体的9-芴基甲氧基羰基化合物。
-
29.发明授权Echinocandin derivatives, their method of preparation and their application as anti-fungal agents 失效棘白菌素衍生物，其制备方法及其作为抗真菌剂的应用公开(公告)号：US07160983B2
公开(公告)日：2007-01-09
申请号：US10666072
申请日：2003-09-19
申请人： Olivier Courtin , Patrick Fauveau , Astrid Markus , Dominique Melon Manguer , Jean-Marc Michel , Laurent Schio
发明人： Olivier Courtin , Patrick Fauveau , Astrid Markus , Dominique Melon Manguer , Jean-Marc Michel , Laurent Schio
IPC分类号： C07K7/50
CPC分类号： A01N43/90 , A61K38/00 , C07D487/18 , C07K7/56
摘要： Compound of the formula wherein R2 is —CH2—CH2—NH2, R3 is —CH3, R4 is —OH, R is Z is methyl and salts thereof which are useful as antifungal agents.
摘要翻译： 下式的化合物其中R 2是-CH 2 -CH 2 -NH 2，其中R 1，R 2， 3是-CH 3，R 4是-OH，R是Z是甲基，其盐可用作抗真菌剂。
-
30.发明授权公开(公告)号：US06962970B2
公开(公告)日：2005-11-08
申请号：US10092088
申请日：2002-03-06
申请人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
发明人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
IPC分类号： A61K38/00 , A61K20060101 , A61K38/14 , A61P31/04 , C07K20060101 , C07K7/06 , C07K9/00 , C07K7/50
摘要： Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译： 公开了具有至少一个下式的取代基的糖肽化合物的衍生物：<？in-line-formula description =“In-line Formulas”end =“lead”？> - R < （Z） <？in-line-formula description =“In-line Formulas”end =“tail”？>其中R a
-
-
-
-
-
-
-
-
-
搜索结果
257 条记录 (耗时 0.039 秒)
