发明申请
- 专利标题： STABILIZED MAML PEPTIDES AND USES THEREOF
- 专利标题（中）： 稳定的乳腺肽及其用途
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申请号： US12478504申请日： 2009-06-04
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公开(公告)号： US20100081611A1公开(公告)日： 2010-04-01
- 发明人: James Bradner , Raymond Moellering , Gregory L. Verdine
- 申请人： James Bradner , Raymond Moellering , Gregory L. Verdine
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; C07K7/50 ; A61P35/00 ; C07K7/08
摘要：
Stably cross-linked a polypeptides related to human MAML are described. These cross-linked polypeptides contain at least two modified amino acids that together form an internal cross-link or tether that can help to stabilize the alpha-helical secondary structure that is thought to be important for binding of MAML peptides to the Notch transcription complex, a complex that includes ICN and CSL.
公开/授权文献
- US09074009B2 Stabilized MAML peptides and uses thereof 公开/授权日：2015-07-07
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